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Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells

A mitochondrial and targeted technology, which is applied in biomaterial analysis, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of difficult identification of primary driver mutations across cancer subtypes

Pending Publication Date: 2020-06-19
LUNELLA BIOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite knowledge of the genomic landscape, modern oncology struggles to identify primary driver mutations across cancer subtypes

Method used

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  • Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
  • Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
  • Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells

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Embodiment Construction

[0016] The following description shows embodiments of the method in sufficient detail to enable the practice of the method. Although the method has been described with reference to these specific embodiments, it should be understood that the method can be embodied in different forms, and that this description should not be construed to limit any appended claims to the specific embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the present method to those skilled in the art.

[0017] Mitochondria are an untapped pathway for treating many diseases, from cancer to bacterial and fungal infections to aging. Functional mitochondria are required for cancer stem cell proliferation. Inhibition of mitochondrial biogenesis and metabolism in cancer cells hampers the proliferation of these cells. Mitochondrial inhibitors thus represent a new class of anticancer therapeutics.

[00...

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Abstract

Antibiotics having intrinsic anti-mitochondrial properties may be chemically modified to target the antibiotics to mitochondria, and the resulting "antimitoscins" may have enhanced anti-cancer properties, among other advantageous properties. Also described are methods for identifying antimitoscins, methods of using antimitoscins to target cancer stem cells, and pharmaceutical compositions for treating cancer containing one or more antimitoscins as the active ingredient. Specific antimitoscins compounds and groups of antimitoscins are also disclosed.

Description

technical field [0001] The present disclosure relates to "antimitoscin", antibiotics with inherent anti-mitochondrial properties, which are chemically modified to target the antibiotic to mitochondria, and include methods of synthesizing antimitoscin, methods of using antimitoscin to target cancer stem cells, and use in the treatment of cancer And a pharmaceutical composition for reducing drug resistance in cancer cells, the pharmaceutical composition comprising one or more antimitoscins as active ingredients. Background technique [0002] Researchers strive to develop new anticancer treatments. Conventional cancer therapies such as radiation, alkylating agents such as cyclophosphamide, and antimetabolites such as 5-fluorouracil have attempted to selectively detect and eradicate rapidly growing cancer cells by interfering with cellular machinery involved in cell growth and DNA replication. Other cancer therapies have used immunotherapies (such as monoclonal antibodies) that...

Claims

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Application Information

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IPC IPC(8): A61K39/00A61K39/395C07K16/00
CPCA61K47/543A61K31/122A61K31/165A61K31/47A61K31/4709A61P35/00G01N2333/70585G01N33/5073A61K31/7048A61K47/548A61K47/54A61K47/542
Inventor M·P·利桑蒂F·苏特加
Owner LUNELLA BIOTECH INC
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