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A kind of sacubitril valsartan sodium pharmaceutical preparation

A technology for sacubitril and pharmaceutical preparations, which is applied in the field of medicine and can solve the problems of easy moisture absorption and reduced stability of active ingredients and the like

Active Publication Date: 2021-03-09
BEIJING WINSUNNY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The sacubitril-valsartan sodium pharmaceutical preparation prepared by the present invention can well solve the problem that the active ingredient of sacubitril-valsartan sodium is easy to absorb moisture, and ensure the smoothness of the preparation process in the preparation process, and will not be affected by the activity The hygroscopic nature of the ingredient makes it less stable

Method used

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  • A kind of sacubitril valsartan sodium pharmaceutical preparation
  • A kind of sacubitril valsartan sodium pharmaceutical preparation
  • A kind of sacubitril valsartan sodium pharmaceutical preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]

[0028] Preparation:

[0029] (1) Mix sacubitril-valsartan sodium, microcrystalline cellulose, dipotassium hydrogen phosphate, and sodium carboxymethyl starch evenly to prepare a mixture;

[0030] (2) dry granulating the mixture obtained in step (1) to obtain drug granules;

[0031] (3) Compress the drug granules into tablets.

Embodiment 2

[0033]

[0034] Preparation:

[0035] (1) Mix sacubitril-valsartan sodium, mannitol, pregelatinized starch, disodium hydrogen phosphate, and low-substituted hydroxypropyl cellulose evenly to prepare a mixture;

[0036] (2) dry granulating the mixture obtained in step (1) to obtain drug granules;

[0037] (3) Mix the drug granules and crospovidone evenly, and press into tablets.

Embodiment 3

[0039]

[0040] Preparation:

[0041] (1) Mix sacubitril-valsartan sodium, lactose, sorbitol, dipotassium hydrogen phosphate, disodium hydrogen phosphate, and croscarmellose sodium to prepare a mixture;

[0042] (2) dry granulating the mixture obtained in step (1) to obtain drug granules;

[0043] (3) Mix the drug granules with low-substituted hydroxypropyl cellulose evenly, and press into tablets.

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Abstract

The invention provides a pharmaceutical preparation of sacubitril-valsartan sodium, which comprises sacubitril-valsartan sodium, a diluent, a stabilizer, and a disintegrant, wherein the stabilizer is dipotassium hydrogen phosphate, phosphoric acid One or both of disodium hydrogen. The sacubitril-valsartan sodium pharmaceutical preparation prepared by the present invention can well solve the problem that the active ingredient of sacubitril-valsartan sodium is easy to absorb moisture, and ensure the smoothness of the preparation process in the preparation process, and will not be affected by the activity The hygroscopic nature of the ingredients makes them less stable.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical preparation of anti-heart failure drug sacubitril-valsartan sodium and a preparation method of the preparation. Background technique [0002] Heart failure is a life-threatening heart condition in which the heart cannot pump enough blood and is at high risk of death, repeated hospitalization and other symptoms (such as difficulty breathing, fatigue, fluid retention) that can seriously affect the patient longevity and quality of life. According to statistics, the number of cardiovascular disease patients in my country is at least 230 million, among which there are 4.2 million heart failure patients, accounting for about 18.67% of the global heart failure patients. At present, drug treatment is still an important means, and the main products in the standard treatment drug market are cardiotonic agents, diuretics and angiotensin-converting enzyme inhibitors. [0003] Sacub...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/41A61K31/216A61K9/20A61K47/02A61P9/04
CPCA61K9/2009A61K31/216A61K31/41A61P9/04A61K2300/00
Inventor 邹文娟傅远鹏耿玉先产运霞
Owner BEIJING WINSUNNY PHARMA CO LTD
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