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Application of two phenylethanoid glycosides in preparation of anti-diabetic drugs

A technology of compounds and drugs, applied in the field of medical applications, to achieve good stability, wide sources, and remarkable effects

Pending Publication Date: 2020-07-03
内蒙古自治区中医医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the research on the activity of the aforementioned two compounds mainly focuses on other aspects such as anti-inflammation, anti-cancer, and anti-aging. There is no relevant literature report on whether they can protect and repair the damage of pancreatic islet cell β cells; that is, they can Whether to develop these two compounds into drugs for protecting and repairing pancreatic β-cell damage (focusing on anti-diabetic drugs) is still a research blank in this field

Method used

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  • Application of two phenylethanoid glycosides in preparation of anti-diabetic drugs
  • Application of two phenylethanoid glycosides in preparation of anti-diabetic drugs
  • Application of two phenylethanoid glycosides in preparation of anti-diabetic drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0020] Embodiment 1: The preparation method of compound verbascoside and isoverbacoside

[0021] 1.1 Plant source

[0022] In this experiment, both verbascoside and isobracoside were extracted from Cymbaria daurica L., a plant of the genus Cymbaria L. in the family Scrophulariaceae. Daurica daurica was obtained in June 2018 In the last ten days, it was collected from Maxi Lahada, Hesi Geula Farm, East Ujimqin Banner, Xilin Gol League, Inner Mongolia Autonomous Region. It was identified as Cymbaria daurica L. by Professor Zhang Chunhong from the Department of Pharmacognosy, Baotou Medical College. .

[0023] 1.2 Extraction and separation

[0024] 1) Weigh 1450g of the dried Dawuli Sinba whole herb, and grind it into medium-fine powder (through a No. 4 sieve). Using heating and reflux method, extract with 70% ethanol for 1 h (material ratio 1:10). After standing to cool, filter the extract. Repeat the extraction 3 times according to the above method. The extracts were comb...

Embodiment 2

[0029] Example 2: Protective and repairing effects of compounds verbascoside and isoverbacoside on alloxan-induced damage to NIT-1 islet β cells

[0030] 2.1 Experimental cells

[0031] NIT-1 cells: Mouse NIT-1 insulinoma β cell line was purchased from Tongpai (Shanghai) Biotechnology Co., Ltd.

[0032] 2.2 Instruments and reagents

[0033] 1640 medium, fetal bovine serum, penicillin-streptomycin, phosphate buffered saline (PBS), 0.25% trypsin (Gibco, USA); DMSO (Hyclone Biochemical (Beijing) Co., Ltd.); rosiglitazone (US sigma company); MTT powder, alloxan. Thermo Scientific Multiskan FC microplate reader (Thermo Company); HHS21-8 electric constant temperature water bath (Beijing Changan Scientific Instrument Factory); 1 / 100,000 electronic balance (Shanghai Precision Scientific Instrument Co., Ltd.).

[0034] 2.3 Experimental method

[0035] 1) NIT-1 islet β cell culture

[0036] Place NIT-1 islet β cells in RPMI1640 medium containing 10% fetal bovine serum, 100U / mL peni...

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Abstract

The invention discloses an application of two phenylethanoid glycosides in preparation of anti-diabetic drugs, and relates to the application of the two phenylethanoid glycosides verbascoside and isoacteoside in the preparation of the drugs for protecting and repairing islet beta cell damage, especially in the preparation of the anti-diabetic drugs. The verbascoside and isoacteoside monomer compounds can be extracted from a plurality of plants, and have the advantages of a wide range of sources, low toxicity and good stability. Through experiments, the inventors verify that the verbascoside and isoacteoside can protect and repair the NIT-1 islet beta cell damage caused by alloxan, and have a remarkable effect. Therefore, the two phenylethanoid glycosides verbascoside and isoacteoside provided by the invention have the potential value to be developed into the anti-diabetic candidate drugs.

Description

technical field [0001] The invention belongs to the technical field of medical applications, and relates to the application of two phenylethanol glycoside compounds in the preparation of antidiabetic drugs, specifically the application of verbascoside and isoverbacoside in the preparation of antidiabetic drugs. Background technique [0002] Diabetes mellitus is a common clinical metabolic disease characterized by hyperglycemia caused by defects in insulin secretion or its biological action, which seriously endangers human life and health. Its main symptoms are reduced tolerance to glucose and disturbance of lipid and protein metabolism. Diabetes will produce many complications such as retinopathy and optic nerve system lesions, and it will increase the risk of cardiovascular disease and stroke. Once you get sick, you will take medicine for life, which will bring a heavy burden to yourself and your family. In recent years, with the development of urbanization, changes in peo...

Claims

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Application Information

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IPC IPC(8): A61K31/7032A61K31/7028A61P3/10
CPCA61K31/7032A61K31/7028A61P3/10A61K2300/00
Inventor 李旻辉吕丽娟张春红张明旭龚雪
Owner 内蒙古自治区中医医院
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