Preparation method, drug delivery system and preparation method of pH-responsive carrier
A drug delivery system and responsive technology, which is applied in the field of preparation of pH-responsive carriers, can solve the problems of low utilization rate of rice bran polysaccharides and restrictions on the application of rice bran polysaccharides, etc.
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[0036] see figure 1 , the preparation method of the pH-responsive carrier comprises the following steps:
[0037] Step S10, dissolving hydrazine hydrate, rice bran polysaccharide, polylactic acid, N,N-dicyclohexylcarbodiimide and 4-dimethylaminopyridine in the first solvent respectively to form hydrazine hydrate solution, rice bran polysaccharide solution, Polylactic acid solution, N,N-dicyclohexylcarbodiimide solution and 4-dimethylaminopyridine solution.
[0038] Wherein, the first solvent may be dimethyl sulfoxide (DMSO), or ultrapure water.
[0039] During specific implementation, step S10 can be realized according to the following steps:
[0040] Step S11, dissolving hydrazine hydrate in the first solvent to obtain a hydrazine hydrate solution.
[0041] Step S12: Take the rice bran polysaccharide, add the first solvent, dissolve it by sonication, centrifuge at 800-1200r / min for 4-6min, take the supernatant and sonicate it for 8-12min, and then filter it with an organic...
Embodiment 1
[0068] (1) Dissolve 2 g of hydrazine hydrate in 5 ml of DMSO to obtain a hydrazine hydrate solution; take 1 g of rice bran polysaccharide, add 50 ml of dimethyl sulfoxide, ultrasonicate for 10 min, centrifuge at 1000 r / min for 5 min, and take the supernatant Sonicate for 10 minutes, then filter with an organic filter to obtain a rice bran polysaccharide solution; take 50 mg of polylactic acid, add 4 ml of dimethyl sulfoxide, shake well, and sonicate for 10 minutes, then filter with an organic filter to obtain a polylactic acid solution; take N, N -Dicyclohexylcarbodiimide 20mg, add 10ml dimethyl sulfoxide, shake well, ultrasonicate for 10min, and then use organic filter to filter to obtain N,N-dicyclohexylcarbodiimide solution; take 4-dimethyl 10 mg of aminopyridine was added to 10 ml of dimethyl sulfoxide, shaken well, then sonicated for 10 min, and then filtered through an organic membrane to obtain a 4-dimethylaminopyridine solution.
[0069] (2) Add 2.5ml of hydrazine hydr...
Embodiment 2
[0074] (1) Dissolve 2.4g of hydrazine hydrate in 5ml of DMSO to obtain a hydrazine hydrate solution; take 1g of rice bran polysaccharide, add 50ml of dimethyl sulfoxide, ultrasonicate for 10min, centrifuge at 800r / min for 6min, and take the supernatant The liquid was ultrasonicated for 8 minutes, and then filtered with an organic filter to obtain a rice bran polysaccharide solution; take 50 mg of polylactic acid, add 4 ml of dimethyl sulfoxide, shake well, and ultrasonically for 10 minutes, then filter with an organic filter to obtain a polylactic acid solution; take N, Add 20 mg of N-dicyclohexylcarbodiimide, add 10ml of dimethyl sulfoxide, shake well, and sonicate for 10 minutes, then filter with an organic membrane to obtain N,N-dicyclohexylcarbodiimide solution; take 4-dicyclohexylcarbodiimide Add 10 mg of methylaminopyridine to 10 ml of dimethyl sulfoxide, shake well, sonicate for 10 minutes, and then filter with an organic membrane to obtain a 4-dimethylaminopyridine solu...
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