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A kind of ophthalmic preparation containing scutellarin, preparation method and application thereof
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A technology of scutellarin and ophthalmic preparations, which is applied in the field of biomedicine, can solve problems such as side reactions, low water solubility, and eye discomfort, and achieve lower intraocular pressure, less irritation, and good stability of content and impurities Effect
Active Publication Date: 2021-06-25
YUNNAN BIOVALLEY PHARMA CO LTD
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Problems solved by technology
[0006] Studies have found that scutellarin can improve the retina and reduce intraocular pressure. However, there are currently no eye drops of scutellarin on the market in China. There are many technical reasons involved. One of them is that scutellarin is a flavonoid drug. The low water solubility is its technical problem, and the second is the low bioavailability of scutellarin, which cannot be directly improved by increasing the concentration. The existing technology often improves its solubility by increasing its solubility and inclusion complexes. , the preparation process is complicated, and the bioavailability is not high, which often brings side effects, such as eye discomfort
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Embodiment 1
[0113] 1000g eye drops
[0114] Scutellarin 20%
[0115] Taurine 3%
[0116] Pharmaceutical excipients include,
[0117] Appropriate amount of KOH
[0118] Benzalkonium Chloride 0.05%
[0119] Polyvinyl alcohol 1.5%
[0120] Na 2 HPO 4 and NaH 2 PO 4 Buffer, appropriate amount
[0121] The balance is water and the pH is 6.5.
[0122] Preparation method: Weigh 200g of scutellarin (Yunnan Biological Valley Pharmaceutical Co., Ltd., HPLC 98% or more), use KOH or NaOH solution for pH, 0.5g of preservative, 15g of polyvinyl alcohol, and 30g of taurine, mix and dissolve with water, and adjust the pH to 6.5. Finally, add the remaining water, filter with a 0.22 μm microporous membrane, and aseptically dispense it into eye drop bottles, and pack it.
Embodiment 2
[0124] 1000g eye drops
[0125] Scutellarin 15%
[0126] Taurine 2%
[0127] Pharmaceutical excipients include,
[0128] Appropriate amount of KOH
[0129] Benzalkonium Chloride 0.05%
[0130] Polyvinyl alcohol 1.5%
[0131] Na 2 HPO 4 and NaH 2 PO 4 Buffer, appropriate amount
[0132] The balance is water and the pH is 6.5.
[0133] The preparation method is the same as in Example 1.
Embodiment 3
[0135] 1000g eye drops
[0136] Scutellarin 10%
[0137] Taurine 1.5%
[0138] Pharmaceutical excipients include,
[0139] Appropriate amount of KOH
[0140] Benzalkonium Chloride 0.03%
[0141] Polyvinyl alcohol 1.2%
[0142] Na 2 HPO 4 and NaH 2 PO 4 Buffer, appropriate amount
[0143] The balance is water, and the pH is about 6.
[0144] The preparation method is the same as in Example 1.
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Abstract
The present invention provides an ophthalmic preparation containing scutellarin, the ophthalmic preparation includes scutellarin, pharmaceutical excipients, and the rest is water, wherein the weight percentage of scutellarin in the ophthalmic preparation is 0.1-20%, the ophthalmic preparation can further improve the medicinal activity of scutellarin and reduce its irritation, which is suitable for industrial production.
Description
technical field [0001] The invention relates to an ophthalmic preparation containing scutellarin and a preparation method thereof, belonging to the field of biomedicine. [0002] technical background [0003] Scutellarin (breviscapus) is an active ingredient of flavonoids isolated from Erigeron breviscapus (Vant.) Hand-Mazz. The main component is scutellarin (also known as scutellarin, scutellarin, below Abbreviated as B), the chemical name is 4', 5, 6-trihydroxyflavone-7-O-gluconoside. According to the revised breviscapine quality standard published by the Pharmacopoeia Commission in August 2013, the content of scutellarin for injection should be greater than 91%. [0004] Taurine is a sulfur-containing amino acid, and taurine in taurine eye drops is the main amino acid in mature retina. Taurine eye drops can promote the growth and development of the retina and relieve ciliary muscle spasm. The taurine in the taurine eye drops competes with reducing sugars in the aqueous h...
Claims
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