Application method of antioxidant in salicylamide synthesis process

A technology of antioxidant and salicylamide, applied in the application field of antioxidant in the synthesis process of salicylamide, can solve the problems of low yield, cumbersome post-processing, need post-processing, etc., and achieves the improvement of product quality and yield. Effect

Inactive Publication Date: 2020-08-07
JIANGSU KUAIDA AGROCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The purity of the crude product by this method is not high, the color is pinkish, and post-processing is required
There are problems such as cumbersome post-processing and low yield

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Add 152g (1mol) of methyl salicylate, 340g (4mol) of 20% ammonia water and 0.152g (0.0012mol) of sodium sulfite into a 1000ml four-necked bottle, stir and heat up to 20°C. The reaction was stirred at 20°C for 8h. Distill excess ammonia, methanol, and part of water, pH = 7~8, cool down to crystallize, filter and dry, the obtained white solid product has a content of 99.0% and a yield of 90.0%.

Embodiment 2

[0026] Add 152g (1mol) of methyl salicylate, 340g (4mol) of 20% ammonia water and 1.52g (0.012mol) of sodium sulfite into a 1000ml four-necked bottle, and stir to lower the temperature to 20°C. The reaction was stirred at 20°C for 8h. Distill excess ammonia, methanol, and part of water, pH = 7~8, cool down to crystallize, filter and dry, the obtained white solid product has a content of 99.3% and a yield of 92.0%.

Embodiment 3

[0028] Add 152g (1mol) of methyl salicylate, 340g (4mol) of 20% ammonia water and 1.52g (0.008mol) of sodium metabisulfite into a 1000ml four-necked bottle, stir and heat up to 20°C. The reaction was stirred at 20°C for 8h. Distill excess ammonia, methanol, and part of water, pH = 7~8, cool down to crystallize, filter and dry, the obtained white solid product has a content of 99.5% and a yield of 92.0%.

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PUM

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Abstract

The invention discloses an application method of an antioxidant in a salicylamide synthesis process, wherein the application method comprises the steps: in the process of synthesizing salicylamide from methyl salicylate, adding the antioxidant, and after reaction is completed, carrying out after-treatment to obtain a finished product white salicylamide. The raw materials of the antioxidant are cheap and easily available; the method has the advantages of simple process, energy conservation, consumption reduction, high production safety and the like; the problem that the color of salicylamide isslightly pink in the existing industrial production is solved; the step of crude product purification is omitted; and the product quality and yield are greatly improved.

Description

technical field [0001] The invention relates to an application method of an antioxidant in the synthesis process of salicylamide. [0002] technical background [0003] The scientific name of salicylamide is 2-hydroxybenzamide. It is a very important organic synthesis intermediate and a raw material for the synthesis of many important derivatives (such as the molluscicide Nitidine, analgesic and antipyretic, etc.), and is widely used in Many fields of medicine, spices, dyes, and rubber additives. Salicylamide is not only an important fine chemical intermediate, but also a widely accepted and widely used antipyretic and analgesic substance, which is used for fever, headache, neuralgia, arthralgia and or active rheumatism, etc. good curative effect. [0004] At present, the method of synthesizing salicylamide mainly uses methyl salicylate amination method, this method is mainly to mix methyl salicylate and ammonia water in a closed reactor, react with 30 ℃, stir for 12 hours,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C231/02C07C235/60C07C231/22C09K15/02
CPCC07C231/02C07C231/22C09K15/02
Inventor 李强徐秀琴徐平平吴崇政陆文豪
Owner JIANGSU KUAIDA AGROCHEM
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