47 results about "Salicylamides" patented technology

Salicylamide derivatives represented by formulae (1a) and (1b); intermediates in the production thereof; a process for producing the same; and drugs containing the same as the active ingredient. The salicylamide derivatives represented by formulae (1a) and (1b) are useful as anti-inflammatory agents and immunosuppressive agents which exert an effect of inhibiting the activation of NF-kappaB with little side effects.

The invention relates to an isoquinolone derivative as well as a preparation method and application thereof. According to a synthesis method, the isoquinolone derivative is prepared from various substituted acetamides as the raw material and a nonmetal as a catalyst under the action of an initiator. Compared with an existing synthesis method, the synthesis method provided by the invention is more economical and environment-friendly, and use of a metal catalyst is avoided. In addition, the synthesis method also has the advantages of being simple in operation, wide in atom economy and wide in substrate adaptability. Furthermore, the compound has a good application prospect in the aspects, such as tumors, cardiovascular diseases, inflammatory diseases, metabolic diseases and neurodegenerative diseases.

The invention discloses a class of compounds with antitumor activity. The structural formula is as follows: In the formula, R is one or two substituents of ethynyl, chlorine, fluorine, trifluoromethyl and 3-fluorobenzyloxy; X is O or NH; Y is CH2 or CO (carbonyl); Z is H or methoxy; n=5 or 6. The salicylic amide compounds in the structural formula are synthesized from 5-nitrosalicylic acid or 4-methoxysalicylic acid and aniline derivatives through amidation, reduction, and reaction with monoethyl pimelic acid chloride. . The compound has a novel structure and the synthesis method is easy to realize. The anti-tumor activity test showed that it has inhibitory effect on the growth of human liver cancer cells (HepG-2), human colon cancer (SW 480) and human prostate cancer cells (PC3), and the activity of most compounds is stronger than that of gefitinib. The use of preparing anti-tumor drug preparations.

A vinyl chloride resin composition comprising 100 parts by mass of a vinyl chloride resin, (a) 0.001 to 10 parts by mass of at least one benzotriazole compound represented by general formula (I), and (b) 0.001 to 10 parts by mass of at least one salicylamide compound represented by general formula (II): wherein R1, R2, R3, and R4 each represent a hydrogen atom, a halogen atom, a hydroxyl group, a nitro group, a carboxyl group, an alkyl group, an alkoxycarbonyl group or an alkanoylamino group. wherein R represents a hydrogen atom, an alkyl group having 1 to 12 carbon atoms or an alkoxy group having 1 to 12 carbon atoms.

The invention relates to a food anti-mildew bactericide. The anti-mildew bactericide is prepared from the following components in parts by mass: 42-46 parts of piperine, 44-48 parts of carbendazim, 40-44 parts of N-dichloroethenyl salicylamide, 44-48 parts of butylated hydroxyanisole, 40-44 parts of tetrabutyl titanate, 44-48 parts of polyoxyethylene sorbitan fatty acid ester, 40-44 parts of ketoconazole, 46-50 parts of prochloraz, 40-44 parts of litsea cubeba oil, 44-48 parts of sodium dichloroisocyanurate, 40-44 parts of panax notoginseng saponins, 44-48 parts of eugenol, 40-44 parts of tween 20, 44-48 parts of potassium sorbate, 40-44 parts of dill seed volatile oil, 44-48 parts of vine tea extract, 40-44 parts of nano-grade titanium dioxide and 44-48 parts of 10,10'-oxybisphenoxarsine. The food anti-mildew bactericide has relatively excellent waterproofing anti-mildew antibacterial performance, can be used as food anti-mildew bactericides, can be used for improving the food storage effect and avoiding mildew, and has a relatively good sterilizing effect.

The invention discloses a class of novel salicylamide compounds (I) and a pharmaceutically acceptable salt thereof, a preparation method and a pharmaceutical composition thereof, and applications of the novel salicylamide compounds (I) and the pharmaceutically acceptable salt thereof in preparation of drugs for treating and / or preventing nervous system related diseases, wherein the diseases include but are not limited to vascular dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, HIV related dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, glaucoma, cerebral arterial thrombosis, cerebral hemorrhagic stroke, nerve injury caused by cerebral trauma and the like.

A wood protectant is prepared from the following raw materials in part by weight: 6-10 parts of N-dichloroethenyl salicylamide, 3-8 parts of xylene, 4-7 parts of Michelia alba, 6-8 parts of honeysuckle, 7-11 parts of agalwood powder, 7-12 parts of quaternary ammonium salt, 4-9 parts of sodium pentachlorophenate, 6-8 parts of isopropanol, 3-9 parts of ethylene glycol monobutyl ether, 5-10 parts of nano titanium oxide, 4-7 parts of borax, and 5-8 parts of diammonium hydrogen phosphate. The wood protectant has the benefits that the wood protectant has good mould-proof and waterproof properties and good permeability and air permeability, and can protect wood well.

The invention discloses a composite oxide catalyst for compounding salicylamide by urea and phenol, a preparation method and application of the composite oxide catalyst. The preparation method comprises the steps of taking nitrate of various metal as a starting material, taking sodium hydroxide and sodium carbonate as a precipitant, preparing a hydrotalcite-like precursor by adopting a method that coprecipitation is performed first, and then hydro-thermal treatment is performed, performing high-temperature calcination, and obtaining the composite oxide catalyst represented in the following general formula: MgxAlyMzOm, wherein M is one of alkaline-earth metal, transition metal or rare-earth metal. Compared with the prior art, the composite oxide catalyst has the advantages of simple preparation method, large specific surface, high activity and the like. Under the effect of the catalyst, the conversion rate of urea can reach 100 percent, the yield of the salicylamide is greater than 99 percent. Meanwhile, the composite oxide catalyst is easy to separate and recycle, and good in catalytic stability, is free from pollution of environment and production equipment, and can still keep higher catalytic activity without regeneration.

The invention provides a preparation method of salicylonitrile. The preparation method comprises the following steps: (1) reacting thionyl chloride with a salicylamide solution to generate a salicylonitrile crude product; and (2) supplementing thionyl chloride into the salicylonitrile crude product, cooling and crystallizing to obtain salicylonitrile. The preparation method is simple in process and high in safety, the reaction process is easy to control, and few impurity byproducts are generated in the reaction; particularly, a crude product post-treatment method is simple and convenient, andthe separation and purification efficiency is high; the preparation method is simple, the yield and purity of the obtained salicylonitrile are high, the mass percentage content of salicylamide in thesalicylonitrile product is effectively controlled to be lower than 0.5%, the purity of the salicylonitrile is up to 95% or above, a large amount of industrial wastewater cannot be generated, and the preparation method is an environment-friendly, simple and efficient preparation process of the high-purity salicylonitrile.

The invention discloses a preparation method and use of N-4-trifluoromethylphenylsalicylamide derivatives shown in a general formula (I). The preparation method of the N-4-trifluoromethylphenylsalicylamide derivatives or pharmaceutically acceptable salt thereof has the advantages of easy acquisition of raw materials and operation easiness and is suitable for industrial production. The N-4-trifluoromethylphenylsalicylamide derivatives have good inhibition effects on growth of a tubercle bacillus standard strain H37Rv and clinical drug-resistant tubercle bacillus, can be used in preparation of an antitubercular drug and has the lowest bacteriostasis concentration of 5 micrograms per milliliter.

The invention relates to the technical field of organic synthesis, in particular to a synthetic method for thioetherification and thiocarbonylation of halogenated alkane. According to the method, a 3-methylthiopropionic acid methyl ester derivative is used as a vulcanizing reagent to realize thioetherification and thiocarbonylation of halogenated alkane; IPrCuCl is used as a catalyst to realize thioetherification; in the presence of carbon monoxide, IPrCuCl and bis-salicylamide ethyl cobalt are used for co-catalysis to obtain thioester; and the vulcanizing reagent is easy to synthesize, mild in reaction condition and high in practicability. According to the invention, thiol with strong smell, high toxicity and environmental pollution is not used, good functional group tolerance and excellent yield and purity are achieved, harsh reaction conditions are not needed, and the method is suitable for industrial production.

The invention relates to a preparation method of nitrile compounds, in particular to a method for preparing salicylonitrile by a salicylamide continuous method. The technical key points are as follows: the method comprises the following operation steps: dissolving salicylamide in an organic solvent to form a solution, preheating the salicylamide solution, introducing the preheated salicylamide solution into a fixed bed reactor filled with a catalyst, reacting under a heating condition, cooling effluent steam, and collecting to obtain a solution of a salicylonitrile product. The salicylamide solution is prepared by dissolving salicylamide in the organic solvent, the defect that a salicylonitrile reaction system is prepared by adopting a melting mode in the prior art is overcome, the reaction energy consumption is effectively reduced, the selectivity and yield of a final product are improved by matching with the improvement of other preparation processes, and the method has industrial value.

The invention discloses polyethylene bellows. The polyethylene bellows are prepared from 100-120 parts by weight of polyethylene resin, 3-5 parts by weight of triethoxyvinylsilane, 1-2 parts by weight of stearic acid, 5-7 parts by weight of powdered steatile, 6-8 parts by weight of calcium carbonate, 4-6 parts by weight of paraffin, 12-14 parts by weight of tetrabromobisphenol S bis(2,3-dibromopropyl)ether, 6-8 parts by weight of antimonous oxide, 0.5-0.7 parts by weight of pentaerythritol tetrakis(3-(3',5'-ditertbutyl-4'-hydroxyphenyl)propionate), 0.2-0.3 parts by weight of salicylamidophthalimide and 2-3 parts by weight of dibutyltin laurate-maleate.

An oral care composition comprising zinc phosphate, stannous fluoride and a salicylamide, as well as methods of using the same.

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and / or inflammatory disorders using the same.

The invention discloses a synthetic method for 5-acetylsalicylamide. The method comprises the following steps: putting anhydrous aluminum chloride and sodium chloride into a container, and performing heating and stirring until both anhydrous aluminum chloride and sodium chloride are fused to obtain low-melting-point NaCl-AlCl3 mixed fused salt; adding salicylamide into the low-melting-point NaCl-AlCl3 mixed fused salt, and stirring until salicylamide is fused; dropwise adding an acylation reagent, and after finishing the dropwise-adding process, producing a heat preservation reaction; immediately and slowly adding acid liquor into an obtained reaction product, and after finishing the process of adding the acid liquor, continuously stirring at the room temperature until no new solids are generated; filtering obtained turbid liquid to obtain a filter cake, and performing washing and drying on the filter cake to obtain a crude product of 5-acetylsalicylamide; purifying the crude product to obtain 5-acetylsalicylamide. The synthetic method for 5-acetylsalicylamide has the advantages of high yield, simple post-treatment, elimination of organic solvents and the like.

The invention discloses a treatment solution applied to cotton mops as well as a preparation method and application of the treatment solution. The treatment solution is prepared from the following raw materials in parts by weight: 0.8-1 part of difenoconazole, 0.4-0.6 part of enestroburin, 0.4-0.6 part of soybean peptide, 3-6 parts of purple sweet potato starch, 0.1-0.2 part of dichloroethenyl salicylamide, 0.1-0.2 part of glycyl-glycine endopeptidase, 2-3 parts of a herba menthae extraction solution, 0.1-0.2 part of polyoxyethylene fatty alcohol sodium sulfate, 1-2 parts of modified traditional Chinese medicine extracts and 150-200 parts of distilled water. Through the treatment solution, the corrosion resistance of cotton cloth can be improved; the treatment solution has an extremely significant sterilization effect; the ultraviolet resistance and the flexibility of the cotton cloth can be improved; the treatment solution is non-corrosive and non-toxic, has high capability of cleaning oil stains and bacteria, and is especially suitable for cleaning kitchen mops; the service life of the mops can be prolonged by 1-2 years.

Methyl salicylate and urea are used as basic raw materials; artificial zeolite, silica gel, aluminum oxide, SiO2, ZrO2 or a molecular sieve and the like are soaked in a phosphoric acid aqueous solution and then fired at a high temperature to obtain immobilized phosphoric acid which takes the artificial zeolite, the silica gel, the aluminum oxide, the SiO2, the ZrO2 or the molecular sieve as a carrier, and the immobilized phosphoric acid is used as a catalyst to perform in-situ catalytic dehydration on methyl salicylate and salicylamide generated by a reaction of urea in an ammonia atmosphere at a high temperature; a mixed material containing o-hydroxybenzonitrile is directly prepared from methyl salicylate and urea; and finally, cooling and condensing are carried out step by step or the condensed mixed material containing the o-hydroxybenzonitrile is rectified to obtain an o-hydroxybenzonitrile product with the mass percentage content of more than 97% at the yield of more than 70% relative to the mass of the methyl salicylate.

The invention discloses a high-temperature-resistant corrugated pipe which is prepared from the following raw materials in parts by weight: 80 to 100 parts of polyethylene resin, 10 to 14 parts of melamine hydrobromide, 3 to 5 parts of phosphinate, 0.5 to 0.7 part of 4{3,-(3',5'-Di-t-butyl-4'-hydroxyphenyl) propionic acid} pentaerythritol ester, 0.2 to 0.3 part of salicylamide phthalimide, 1 to 2 parts of dibutyltin dilaurate maleate, 2 to 4 parts of 3,4-dimethyl-3,4-diphenyl hexane, 1 to 2 parts of borate and 0.5 to 1 part of pentaerythritol stearate. A preparation method of the high-temperature-resistant corrugated pipe comprises the following steps: mixing the raw materials, adding polyethylene resin and carrying out extruding granulation via an extruder at an extruding temperature of 190 DEG C to 210 DEG C; and adding obtained granules into a single screw extruder, extruding and molding a pipe material at the extruding temperature of 180 DEG C to 190 DEG C and under the extruded pipe pulling speed within 3 to 5m / min so as to obtain the corrugated pipe.

The invention discloses a method for synthesizing salicylamide by a continuous method, which comprises the steps of (1) carrying out acylating chlorination reaction on an acylating chlorination reagent phosgene and a salicylic acid solution in a continuous reactor to obtain salicyloyl chloride; (2) carrying out esterification reaction on salicyloyl chloride and methanol in the continuous reactor to obtain methyl salicylate; and (3) carrying out ammoniation reaction on the methyl salicylate and the methanol solution of ammonia in the continuous reactor to obtain salicylamide. The process has the beneficial effects that (1) the reaction yield of methyl salicylate is increased (98% or above), and no wastewater or waste acid is discharged; (2) the reaction yield of salicylamide is improved (98% or above), and no ammonia-nitrogen-containing wastewater is discharged; (3) the process realizes the continuous reaction of salicylamide, and saves the purification energy consumption and cost of the product; and (4) the product purity is high, and the operation is simple.

The present invention relates to salicylamide compounds and compositions thereof effective in targeting growth of bacteria. The compounds and compositions of the present invention are particularly useful in, for example, the prevention or treatment of bacterial infection and the prevention, reduction or elimination of biofilm formation.

The invention discloses a composite oxide catalyst for compounding salicylamide by urea and phenol, a preparation method and application of the composite oxide catalyst. The preparation method comprises the steps of taking nitrate of various metal as a starting material, taking sodium hydroxide and sodium carbonate as a precipitant, preparing a hydrotalcite-like precursor by adopting a method that coprecipitation is performed first, and then hydro-thermal treatment is performed, performing high-temperature calcination, and obtaining the composite oxide catalyst represented in the following general formula: MgxAlyMzOm, wherein M is one of alkaline-earth metal, transition metal or rare-earth metal. Compared with the prior art, the composite oxide catalyst has the advantages of simple preparation method, large specific surface, high activity and the like. Under the effect of the catalyst, the conversion rate of urea can reach 100 percent, the yield of the salicylamide is greater than 99 percent. Meanwhile, the composite oxide catalyst is easy to separate and recycle, and good in catalytic stability, is free from pollution of environment and production equipment, and can still keep higher catalytic activity without regeneration.

The invention relates to a preparation method of nitrile compounds, in particular to a method for preparing salicylonitrile by a continuous salicylamide method. The technical points are as follows, including the following operation steps: dissolving salicylamide in an organic solvent to form a solution, preheating the salicylamide solution into a fixed-bed reactor filled with a catalyst, reacting under heating conditions, and flowing out steam Collected after cooling to obtain a solution of the salicylonitrile product. The present invention prepares salicylamide solution by dissolving salicylamide in an organic solvent, overcomes the preparation of salicylonitrile reaction system by melting method in the prior art, effectively reduces reaction energy consumption, and cooperates with other preparation process improvements The selectivity and yield of the final product are improved, and the method has industrial value.

The invention discloses a polymethyl Schiff base, and a preparation method and application thereof. The preparation method comprises the following steps: reacting salicylamide with formaldehyde in a sodium hydroxide solution to obtain a product A; and reacting the product A with piperazine to obtain the polymethyl Schiff base. The salicylamide is prepared by reacting salicylaldehyde with ethylenediamine. The polymethyl Schiff base disclosed by the invention can effectively inhibit corrosion at high temperature, and has the advantages of low cost, high efficiency, convenience in use and the like when being used as an anti-corrosion measure; and when is the polymethyl Schiff base is suitable for corrosion inhibition of low-carbon steel at high temperature, an excellent using effect can be achieved.

The invention discloses a method for preparation of Carsalam by a reaction of salicylamide with diethyl carbonate in the presence of an alkali ethoxide.

An oral care composition comprising zinc phosphate, stannous fluoride and a salicylamide, as well as methods of using the same.

The invention discloses a solid beverage capable of reducing uric acid and a preparation method thereof, and belongs to the technical field of functional beverage preparation. The solid beverage capable of reducing uric acid comprises the following raw materials: erythropalum scandens, plantain herb, dandelion, herba portulacae, folium mori, rhizoma smilacis glabrae, water, nicotinamide, vitamin C, calcium salt, a sweetening agent, 8-salicylamide sodium caprylate, sodium alginate, tea polyphenol, polyvinylpyrrolidone and an embedding medium. The raw materials such as erythropalum scandens, plantain herb, dandelion, herba portulacae, folium mori, rhizoma smilacis glabrae are dried and crushed by adopting vacuum freeze drying and low-temperature nano crushing technologies, such that effective components of the raw materials can be reserved to the greatest extent. The effective components are completely dissolved out by adopting ultrasonic cell wall breaking and subcritical extraction technologies, such that a utilization rate is increased, absorption is promoted, and the prepared solid beverage can effectively reduce uric acid value of animals.

The invention discloses a high-performance corrugated pipe. The high-performance corrugated pipe is formed by, by weight percent, 80 to 100 parts of polyethylene resin, 25 to 35 parts of calcium carbonate, 0.5 to 1 parts of titanate, 1 to 2 parts of stearic acid, 6 to 8 parts of tetrabromobisphenol S bis(2,3-dibromopropyl)ether, 3 to 5 parts of antimonous oxide, 0.5 to 0.7 part of pentaerythritol tetrakis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate] pentaerythritol ester, 0.2 to 0.3 part of salicin acylamino phthalimide and 1 to 2 parts of lauric acid dibutyltin maleate. The calcium carbonate, the titanate, the stearic acid, the tetrabromobisphenol S bis(2,3-dibromopropyl)ether, the antimonous oxide, the pentaerythritol tetrakis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate]pentaerythritol ester, the salicin acylamino phthalimide and the lauric acid dibutyltin maleate are mixed in a thermal mixing machine, then the polyethylene resin is added to perform extrusion and granulation, granules are added to a single screw extruder to be extruded, a pipeline is formed, and the corrugated pipe is obtained.