20 results about "Salicylamides" patented technology

The invention discloses a dual-emission molecular imprinting ratiometric fluorescence sensor, a preparation method thereof and application of the dual-emission molecular imprinting ratiometric fluorescence sensor in aureomycin detection, and belongs to the technical field of chemical sensors. The preparation method of the sensor comprises the following steps: preparing silicon dioxide-quantum dot composite nanoparticles, and preparing a molecularly imprinted polymer by taking salicylamide as a template molecule; and mixing the molecularly imprinted polymer and the silicon dioxide-quantum dot composite nanoparticles in an HEPES buffer solution by adopting a post-mixing strategy to construct the dual-emission molecularly imprinted ratiometric fluorescence sensor. The double-emission molecular imprinting ratiometric fluorescence sensor has the beneficial effects that the double-emission molecular imprinting ratiometric fluorescence sensor provided by the invention is rich in fluorescence color change, rapid, high-sensitivity and visual detection of aureomycin can be realized, the whole detection process is simple, convenient and rapid, and the double-emission molecular imprinting ratiometric fluorescence sensor is suitable for being widely popularized in practical application.

The invention discloses a 2-hydroxy-benzonitril solution and a production method thereof, the production method comprises the step of preparing a wet 2-hydroxy-benzonitril product through reaction of salicylamide and phosgene, and is characterized in that the wet 2-hydroxy-benzonitril product is directly added into a sodium hydroxide aqueous solution to obtain the 2-hydroxy-benzonitril solution. The sodium salt solution can be directly produced without taking out the 2-hydroxy-benzonitril, so that exposure of the 2-hydroxy-benzonitril is avoided, personal injury is reduced, investment of drying equipment is reduced, and direct feeding of downstream products is facilitated.

This invention discloses a dual-emission molecularly imprinted ratiometric fluorescence sensor, its preparation method, and its application in the detection of chlortetracycline, belonging to the field of chemical sensor technology. The preparation method of this sensor includes the following steps: preparing silica-quantum dot composite nanoparticles; preparing a molecularly imprinted polymer using salicylamide as a template molecule; and using a post-mixing strategy to mix the molecularly imprinted polymer and silica-quantum dot composite nanoparticles in HEPES buffer to construct the dual-emission molecularly imprinted ratiometric fluorescence sensor. The advantages of this invention are: the dual-emission molecularly imprinted ratiometric fluorescence sensor provided by this invention exhibits rich fluorescence color changes, enabling rapid, highly sensitive, and visual detection of chlortetracycline; and the entire detection process is simple, convenient, and fast, making it suitable for widespread application in practical applications.

The invention discloses a synthesis method of a high-purity and high-yield antihypertensive drug, and relates to the technical field of medical chemistry. The method comprises the following steps: taking glycollic acid as an initial raw material, and carrying out acylation to obtain glycollic acid acyl chloride; carrying out Friedel-Crafts reaction on the 2-hydroxyl-5-(2-hydroxyacetyl) benzamide and salicylamide to obtain 2-hydroxyl-5-(2-hydroxyacetyl) benzamide; then, a Dess-Martin oxidizing agent is used for oxidation, and 2-hydroxy-5-(2-oxoacetyl) benzamide is obtained; the preparation method comprises the following steps: taking 2-hydroxyl-5-((4-phenylbutylamine-2-yl)-ethyl) benzamide as a raw material, then carrying out reductive amination on the 2-hydroxyl-5-(4-phenylbutylamine-2-yl)-ethyl) benzamide and 1-methyl-3-phenylpropylamine under the condition that sodium borohydride is taken as a reducing agent to obtain 2-hydroxyl-5-(1-hydroxyl-2-((4-phenylbutylamine-2-yl)-amino) ethyl) benzamide, namely And finally salifying with concentrated hydrochloric acid, crystallizing and separating to obtain the labeolol hydrochloride. The method is novel in route, convenient to operate, high in product total yield, high in purity, capable of effectively avoiding generation of dibromo impurities and suitable for large-scale production.

The invention discloses a method for synthesizing 5-(N, N-dibenzyl amino acetyl) salicylamide, which comprises the following steps: by taking benzaldehyde and benzylamine as raw materials and ethanol as a solvent, heating to a reaction temperature by using a micro-channel reactor, and reacting to obtain N-benzylidene benzylamine after the reaction is finished; taking the prepared N-benzylidene benzylamine as a raw material, adding hydrogen and a palladium carbon catalyst, reacting, and discharging the hydrogen after the reaction to obtain dibenzylamine; 5-bromoacetyl salicylamide and the prepared dibenzylamine are taken as raw materials, K2CO3 is taken as an acid-binding agent (or a deep eutectic solvent is used for replacing the acid-binding agent), acetonitrile is taken as a solvent, the materials are dropwise added under a low-temperature condition, a temperature rise reaction is carried out after dropwise adding is completed, the pH value of an obtained solid is adjusted with diluted hydrochloric acid to be acidic, then filtering, washing and drying are carried out, and the target product 5-(N, N-dimethyl-N, N-dimethyl formamide) is obtained. The compound is N, N-dibenzyl amino acetyl) salicylamide. The method has the advantages that the method is simple, the microchannel reactor is used, the product yield is high, the purity is high, and industrial production is easy.

The application provides a preparation method of 2,2-bis(3-amino-4-hydroxyphenyl) hexafluoropropane, which comprises the following steps: S1: under a protective atmosphere, uniformly mixing hexafluoroacetone trihydrate with salicylamide, stirring, temperature rising, temperature control and dropwise adding Eaton reagent, after reaction, temperature falling, ice water quenching, filtering, water washing, ethanol beating, and drying to obtain compound (I); S2: under the protective atmosphere, adding the compound (I) obtained in step (1) into a hypochlorite and alkali solution, stirring, dissolving, temperature rising and reaction, after reaction, post-treatment is carried out to obtain compound (II). The application has the beneficial effects that the preparation method is novel, raw materials are easy to obtain, selectivity is good, the overall preparation cost is low, the yield is high, and the method is suitable for industrial production.

This invention provides a method for preparing labetalol hydrochloride, belonging to the field of pharmaceutical synthesis. The method uses 5-acetylsalicylic acid as a starting material, obtains 3-bromo-5-(2-bromoacetyl)-2-hydroxybenzamide through bromination, then undergoes a substitution reaction with 1-methyl-3-phenylpropylamine, followed by hydrogenation reduction, and finally salt formation to obtain labetalol hydrochloride. The method provides a high conversion rate and few byproducts by using the synthesized 3-bromo-5-(2-bromoacetyl)-2-hydroxybenzamide intermediate to replace 5-bromoacetylsalicylic acid. The obtained product can be directly used in the next reaction, followed by substitution and reduction to obtain the final product. This method is low-cost, high-yield, simple, and controllable, facilitating industrialized production and showing excellent application prospects.

This invention relates to the application of salicylamide derivatives in the preparation of anti-small RNA virus drugs, belonging to the field of antiviral drug technology. This invention discloses the application of salicylamide and / or its derivatives in the preparation of anti-small RNA virus drugs. Through various experimental methods, this invention confirms that niclosamide and its derivatives HJW1107 and CZY1111 can significantly inhibit the early infection and replication of small RNA viruses such as EMCV, EV-D68, and CVA10, inhibit virus-induced cytopathic effects, and enhance the survival rate of infected cells. This indicates that niclosamide and its derivatives HJW1107 and CZY1111 have broad-spectrum antiviral activity and can be used to prepare therapeutic drugs against small RNA virus infections, thereby preventing and treating diseases caused by small RNA viruses, and has good clinical application prospects.

The invention relates to the technical field of salicylamide processing, and provides a reaction device for processing salicylamide, the reaction device comprises a reaction tank and support legs, the top end of the reaction tank is fixedly provided with a cover body, and the top end of the cover body is provided with a driving motor. By arranging a mixing structure, a stirring shaft drives a driving fluted disc to rotate in a shell, the driving fluted disc drives a driven fluted disc to rotate through a bevel gear, and at the moment, the driven fluted disc drives a frame body to rotate in a reaction tank through a connecting seat; the frame body can drive the first rubber scraping plate and the second rubber scraping plate to scrape the inner side of the reaction tank, attached materials can be conveniently removed, meanwhile, the auxiliary stirring blades can be driven to stir the materials in the reaction tank, the rotating directions of the auxiliary stirring blades and the main stirring blades are opposite, and therefore a fixed flow field formed by the main stirring blades can be destroyed, and the stirring effect is improved. The reaction device for processing salicylamide realizes the function of facilitating uniform mixing, so that the working efficiency of the reaction device for processing salicylamide in use is improved.

The invention provides an extraction system and method for extracting and enriching lithium from a lithium-containing sodium sulfate solution. The extraction system comprises an extraction agent, a synergistic extraction agent, a diluent and a modifier, and the extraction agent is salicylamide as shown in a formula (I); the synergistic extractant is a neutral organic phosphorus compound with lithium coordination capability. According to the method, salicylamide is used as an extraction agent, phosphorus-containing reagents such as tributyl phosphate are used as a synergistic extraction agent, the extraction agent and other organic solvents are used for constructing an extraction system, lithium ions are extracted from a lithium-containing sodium sulfate solution, and then washing and reverse extraction are carried out, so that the ions are finally enriched in reverse extraction liquid. Compared with beta-diketone and salicylate lithium extraction, the method has the characteristics of stable chemical structure, mild synthetic route and cheap and easily available raw materials.

Provided is a compound or a pharmaceutically acceptable salt, prodrug, or metabolite thereof, or a solvate or hydrate of any of the foregoing and a use in treatment of a disease or disorder.

The invention discloses a preparation method of a drug intermediate 8-(2-benzamido) sodium caprylate, which comprises the following steps: in the presence of a solvent A or a catalyst, reacting salicylamide with triethyl orthoformate to obtain a compound I-1; (2) in the presence of alkali and a solvent B, carrying out substitution reaction on the compound I-1 and 8-bromocaprylic acid tert-butyl ester to obtain a compound I-2; (3) in the presence of an acid and a solvent C, carrying out a deprotection reaction on the compound I-2 to obtain a compound I-3; and (4) in the presence of a solvent D, reacting the compound I-3 with alkali salt of sodium to obtain the compound I. The method provided by the invention has the advantages of high yield, high selectivity, low production cost, few byproducts, easiness in industrial production and environmental friendliness.

A low-temperature seed-induced growth method for salicylamide ultrafast scintillation crystals is disclosed, involving ultrafast scintillation crystals and their low-temperature seed-induced growth method. This method aims to solve the technical problems of uncontrollable growth rate, sensitivity to environmental fluctuations, easy generation of microscopic defects within the crystal, and poor dimensional regularity in existing organic crystal scintillators. The method comprises: 1. Obtaining high-quality seed crystals through isothermal volatilization; 2. Preparing a saturated growth solution; 3. Precise temperature equilibration treatment; 4. Seed crystal-induced slow volatilization growth. The salicylamide single crystals prepared by this method reach a size of 15mm × 9mm × 1.5mm. Its photo-induced decay time is approximately 5.93 ns. 137 The radioactive decay time under Cs excitation is approximately 2.82 ns, which can be used in the field of radiation detection.

Salicylamide compounds and methods of their use are provided, as well as pharmaceutical compositions including the salicylamide compounds and methods of using the pharmaceutical compounds.

The invention discloses a continuous reaction system for producing 2-hydroxy-benzonitrile, which comprises two groups of batching kettles, a static mixer, a micro-channel reactor and a heat exchanger, the two groups of batching kettles are respectively salicylamide-o-xylene solution preparation kettles and thionyl chloride-catalyst system preparation kettles; the batching kettle is communicated with the static mixer through a pipeline, the static mixer is communicated with the micro-channel reactor, reaction liquid enters the heat exchanger from an outlet of the micro-channel reactor for cooling, an outlet of the heat exchanger is communicated with an inlet of the degassing tower, the bottom of the degassing tower is communicated with an alkalization kettle, and the alkalization kettle is communicated with a multi-stage crystallization kettle. And the multi-stage crystallization kettle is communicated with a vacuum drying box. According to the system disclosed by the invention, the degassing tower, the alkalization kettle and the multi-stage crystallization are connected in series, so that the integration of reaction, separation and purification is realized. The degassing tower adopts nitrogen stripping to recover unreacted SOCl2, and three-stage tail gas absorption is matched, so that the utilization rate of SOCl2 is increased to 95% or above, and the environmental protection requirement is met.

The invention discloses a purification process for producing 2-hydroxy-benzonitril, and belongs to the technical field of 2-hydroxy-benzonitril purification. The purification process comprises the following steps: dissolving a crude product of 2-hydroxy-benzonitrile in methanol, carrying out specific adsorption in a methanol medium by using a salicylamide adsorbent and a salicylic acid adsorbent in sequence, removing the adsorbed adsorbent through magnetic separation, and finally recrystallizing by using toluene as a solvent. According to the invention, a salicylamide and salicylic acid adsorbent is designed by purifying a crude product of 2-hydroxy-benzonitrile synthesized by taking salicylamide as a raw material, magnetic and porous Fe3O4 (at) SiO2 nanoparticles are taken as a carrier to load a specific adsorption molecularly imprinted polymer, the salicylamide and the salicylic acid are accurately recognized, and meanwhile, the specific adsorption capacity of the salicylamide and the salicylic acid is greatly improved, so that the specific adsorption capacity of the salicylamide and the salicylic acid is improved, and the specific adsorption capacity of the salicylamide and the salicylic acid is improved. According to the method, high-efficiency adsorption can be realized under the condition of low content of salicylic acid and salicylamide, the purification of the 2-hydroxy-benzonitrile crude product is completed, and the purified finished product is high in purity and is more beneficial to subsequent application.

The invention discloses a preparation process of 2-hydroxy-benzonitrile, which belongs to the field of organic chemical industry, and comprises the following steps: dissolving salicylamide in a solvent to obtain a salicylamide solution, introducing the salicylamide solution into a continuous reactor together with ammonia gas, reacting at 350-400 DEG C at the reaction space velocity of 0.1-1.5 h <-1 >, cooling effluent steam, collecting, filtering, and recrystallizing with toluene to obtain the 2-hydroxy-benzonitrile, the continuous reactor is filled with a modified alpha-ZrP-based catalyst. According to the method, the modified alpha-ZrP-based catalyst is taken as a core, and the continuous reaction and the ammonia atmosphere are combined, so that high-efficiency and environment-friendly dehydration of salicylamide is realized to prepare the 2-hydroxy-benzonitrile.

The present application belongs to the technical field of organic compound synthesis, and relates to a method for synthesizing 3-indolyl benzoquinone compounds, which is used to solve the technical problems that the preparation of the existing 3-indolyl benzoquinone compounds needs additional oxidants or a large amount of hydroquinone by-products is inevitably generated in the reaction system due to the use of more than 2 equivalents of benzoquinone compounds. The method is that: in an oxygen or air environment, a C2 substituted indole compound and a hydroquinone compound are reacted in a mixed solution of water and an organic solvent with Salcomine as a catalyst to generate a 3-indolyl benzoquinone compound. The catalyst system of the present application is simple, the reaction selectivity is excellent, the by-products are few, and the reaction efficiency is high; the synthesis process is simple, the waste is little, the environment is friendly, and the present application has a strong industrial application prospect.

The invention discloses a dual-emission molecular imprinting ratiometric fluorescence sensor, a preparation method thereof and application of the dual-emission molecular imprinting ratiometric fluorescence sensor in aureomycin detection, and belongs to the technical field of chemical sensors. The preparation method of the sensor comprises the following steps: preparing silicon dioxide-quantum dot composite nanoparticles, and preparing a molecularly imprinted polymer by taking salicylamide as a template molecule; and mixing the molecularly imprinted polymer and the silicon dioxide-quantum dot composite nanoparticles in an HEPES buffer solution by adopting a post-mixing strategy to construct the dual-emission molecularly imprinted ratiometric fluorescence sensor. The double-emission molecular imprinting ratiometric fluorescence sensor has the beneficial effects that the double-emission molecular imprinting ratiometric fluorescence sensor provided by the invention is rich in fluorescence color change, rapid, high-sensitivity and visual detection of aureomycin can be realized, the whole detection process is simple, convenient and rapid, and the double-emission molecular imprinting ratiometric fluorescence sensor is suitable for being widely popularized in practical application.

The invention discloses a low-temperature seed crystal induced growth method of a salicylamide ultrafast scintillation crystal, and relates to an ultrafast scintillation crystal and a low-temperature seed crystal induced growth method thereof. The invention aims to solve the technical problems that the growth rate is uncontrollable, the environmental fluctuation is sensitive, microdefects are easily generated in the crystal and the size regularity is poor in the growth process of the existing organic crystal scintillator. The method comprises the following steps: 1, obtaining high-quality seed crystals by a constant-temperature volatilization method; 2, preparing a growth saturated solution; 3, carrying out precise temperature balance treatment; 4, seed crystal induction slow volatilization growth. The size of the salicylamide single crystal prepared by the method reaches 15mm * 9mm * 1.5 mm. The light-induced decay time is about 5.93 ns, the radiation-induced decay time under the excitation of a 137Cs radioactive source is about 2.82 ns, and the material can be used in the field of radiation detection.