44 results about "Salicylamides" patented technology

Salicylamide derivatives represented by formulae (1a) and (1b); intermediates in the production thereof; a process for producing the same; and drugs containing the same as the active ingredient. The salicylamide derivatives represented by formulae (1a) and (1b) are useful as anti-inflammatory agents and immunosuppressive agents which exert an effect of inhibiting the activation of NF-kappaB with little side effects.

The invention discloses a composite oxide catalyst for compounding salicylamide by urea and phenol, a preparation method and application of the composite oxide catalyst. The preparation method comprises the steps of taking nitrate of various metal as a starting material, taking sodium hydroxide and sodium carbonate as a precipitant, preparing a hydrotalcite-like precursor by adopting a method that coprecipitation is performed first, and then hydro-thermal treatment is performed, performing high-temperature calcination, and obtaining the composite oxide catalyst represented in the following general formula: MgxAlyMzOm, wherein M is one of alkaline-earth metal, transition metal or rare-earth metal. Compared with the prior art, the composite oxide catalyst has the advantages of simple preparation method, large specific surface, high activity and the like. Under the effect of the catalyst, the conversion rate of urea can reach 100 percent, the yield of the salicylamide is greater than 99 percent. Meanwhile, the composite oxide catalyst is easy to separate and recycle, and good in catalytic stability, is free from pollution of environment and production equipment, and can still keep higher catalytic activity without regeneration.

The invention relates to a preparation method of nitrile compounds, in particular to a method for preparing salicylonitrile by a salicylamide continuous method. The technical key points are as follows: the method comprises the following operation steps: dissolving salicylamide in an organic solvent to form a solution, preheating the salicylamide solution, introducing the preheated salicylamide solution into a fixed bed reactor filled with a catalyst, reacting under a heating condition, cooling effluent steam, and collecting to obtain a solution of a salicylonitrile product. The salicylamide solution is prepared by dissolving salicylamide in the organic solvent, the defect that a salicylonitrile reaction system is prepared by adopting a melting mode in the prior art is overcome, the reaction energy consumption is effectively reduced, the selectivity and yield of a final product are improved by matching with the improvement of other preparation processes, and the method has industrial value.

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

The invention discloses a synthetic method for 5-acetylsalicylamide. The method comprises the following steps: putting anhydrous aluminum chloride and sodium chloride into a container, and performing heating and stirring until both anhydrous aluminum chloride and sodium chloride are fused to obtain low-melting-point NaCl-AlCl3 mixed fused salt; adding salicylamide into the low-melting-point NaCl-AlCl3 mixed fused salt, and stirring until salicylamide is fused; dropwise adding an acylation reagent, and after finishing the dropwise-adding process, producing a heat preservation reaction; immediately and slowly adding acid liquor into an obtained reaction product, and after finishing the process of adding the acid liquor, continuously stirring at the room temperature until no new solids are generated; filtering obtained turbid liquid to obtain a filter cake, and performing washing and drying on the filter cake to obtain a crude product of 5-acetylsalicylamide; purifying the crude product to obtain 5-acetylsalicylamide. The synthetic method for 5-acetylsalicylamide has the advantages of high yield, simple post-treatment, elimination of organic solvents and the like.

The invention discloses a treatment solution applied to cotton mops as well as a preparation method and application of the treatment solution. The treatment solution is prepared from the following raw materials in parts by weight: 0.8-1 part of difenoconazole, 0.4-0.6 part of enestroburin, 0.4-0.6 part of soybean peptide, 3-6 parts of purple sweet potato starch, 0.1-0.2 part of dichloroethenyl salicylamide, 0.1-0.2 part of glycyl-glycine endopeptidase, 2-3 parts of a herba menthae extraction solution, 0.1-0.2 part of polyoxyethylene fatty alcohol sodium sulfate, 1-2 parts of modified traditional Chinese medicine extracts and 150-200 parts of distilled water. Through the treatment solution, the corrosion resistance of cotton cloth can be improved; the treatment solution has an extremely significant sterilization effect; the ultraviolet resistance and the flexibility of the cotton cloth can be improved; the treatment solution is non-corrosive and non-toxic, has high capability of cleaning oil stains and bacteria, and is especially suitable for cleaning kitchen mops; the service life of the mops can be prolonged by 1-2 years.

Methyl salicylate and urea are used as basic raw materials; artificial zeolite, silica gel, aluminum oxide, SiO2, ZrO2 or a molecular sieve and the like are soaked in a phosphoric acid aqueous solution and then fired at a high temperature to obtain immobilized phosphoric acid which takes the artificial zeolite, the silica gel, the aluminum oxide, the SiO2, the ZrO2 or the molecular sieve as a carrier, and the immobilized phosphoric acid is used as a catalyst to perform in-situ catalytic dehydration on methyl salicylate and salicylamide generated by a reaction of urea in an ammonia atmosphere at a high temperature; a mixed material containing o-hydroxybenzonitrile is directly prepared from methyl salicylate and urea; and finally, cooling and condensing are carried out step by step or the condensed mixed material containing the o-hydroxybenzonitrile is rectified to obtain an o-hydroxybenzonitrile product with the mass percentage content of more than 97% at the yield of more than 70% relative to the mass of the methyl salicylate.

The present invention relates to salicylamide compounds and compositions thereof effective in targeting growth of bacteria. The compounds and compositions of the present invention are particularly useful in, for example, the prevention or treatment of bacterial infection and the prevention, reduction or elimination of biofilm formation.