Medicine with intervention effect on skin photoaging caused by UVA, and animal model

A technology of skin photoaging and animal models, applied in the field of animal models and medicines, can solve problems such as ambiguity and unrecognized effects

Active Publication Date: 2020-08-11
GUANGZHOU CENT FOR DISEASE CONTROL & PREVENTION (GUANGZHOU HYGIENE INSPECTION CENT GUANGZHOU CENT FOR FOOD SAFETY RISK SURVEILLANCE & ASSESSMENT INST OF PUBLIC HEALTH OF GUANGZHOU MEDICAL UNIV) +1
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Problems solved by technology

However, whether I3C can prevent or delay photoaging through this pathway is still unclear
[0008] Through the above analysis, the problems and defects of the existing technology are: the existing technology is mainly used to solve the chemopreventive effect of various tumors,

Method used

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  • Medicine with intervention effect on skin photoaging caused by UVA, and animal model
  • Medicine with intervention effect on skin photoaging caused by UVA, and animal model
  • Medicine with intervention effect on skin photoaging caused by UVA, and animal model

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Embodiment Construction

[0077] In order to make the objectives, technical solutions, and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention.

[0078] In view of the problems existing in the prior art, the present invention provides a drug and animal model for the intervention of UVA-induced skin photoaging. The present invention will be described in detail below with reference to the accompanying drawings.

[0079] The drug for the intervention of UVA-induced skin photoaging provided by the embodiment of the present invention is indole-3-carbinol, and the maximum non-effect dose on HaCaT cells is 10 umol / L.

[0080] Such as figure 1 As shown, the method for constructing an animal model of a drug for the intervention of UVA-induced skin photoaging provided by the ...

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and discloses a medicine with an intervention effect on skin photoaging caused by UVA, and an animal model. The medicine isindole-3-methanol, and the maximum inactive dose on HaCaT cells is 10 mu mol/L. HaCaT cells in a logarithmic phase are taken to be inoculated into a 6-hole culture plate according to 2 *105 piece/hole to be cultured in a cell culture box until the cell fusion degree is 70-80%; processing is carried out as follows: a blank control group is covered with a lightproof black paper sheet, the irradiation dose of a UVA model group is 1 J/cm2, an I3C treatment group is treated with 10 [mu] mol/L I3C while UVA irradiating is carried out, and two parallel samples are set for each dose; and the change of the number and morphology of the cells are observed after the irradiation is finished. According to the medicine, the lesions of mouse skin epidermal cells and fiber tissues caused by excessive UVAirradiation can be improved, such that the formation of skin photoaging can be delayed.

Description

Technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a drug and an animal model for interfering with UVA-induced skin photoaging. Background technique [0002] Human skin aging is a very complicated process, and genetic factors and environmental factors affect it at the same time. At present, it has been found that ultraviolet rays in environmental factors are an important cause of skin aging. Human skin receives ultraviolet radiation from sunlight every day. Studies have shown that long-term ultraviolet radiation will cause skin photoaging and even skin cancer. With the improvement of human living standards and the growth of the aging population, the problem of skin aging has attracted increasing attention. Due to the increasing destruction of the ozone layer in the atmosphere and other factors such as living habits, skin photoaging has also become one of the important health problems that threaten mode...

Claims

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Application Information

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IPC IPC(8): A61K31/40A61P17/18C12N5/071C12N13/00G01N33/573
CPCA61K31/40A61P17/18C12N5/0625C12N13/00G01N33/573
Inventor 朱伟叶兴东殷花杨光宇李文学张岩李军涛杨智聪
Owner GUANGZHOU CENT FOR DISEASE CONTROL & PREVENTION (GUANGZHOU HYGIENE INSPECTION CENT GUANGZHOU CENT FOR FOOD SAFETY RISK SURVEILLANCE & ASSESSMENT INST OF PUBLIC HEALTH OF GUANGZHOU MEDICAL UNIV)
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