The application relates to a preparation method and application of a
ginsenoside-loaded triple-assembled
Pickering emulsion, and belongs to the
biomedical technology field. In order to solve the problems that the
Pickering emulsion constructed by natural active ingredients in the prior art has insufficient
mechanical strength of an interface film, is easy to break and lose stability, has passive release behavior, lacks
controllability and environmental responsiveness, and is difficult to realize precise release, a
ginsenoside-loaded triple-assembled
Pickering emulsion is provided. Through a three-step
cascade strategy of "molecule-interface-function", a stable "
metal-
phenol coordination network"
interface layer is constructed on the surface of oil droplets, the physical and
chemical stability of the
emulsion is fundamentally improved, a Pickering
emulsion which is all-natural, highly stable and has a pH response intelligent release function is successfully constructed, and the triple-assembled Pickering
emulsion has significant advantages in stability, controllable release and function integration, and provides a feasible technical strategy for a
response type delivery system design based on natural products.