Application of compound in preparation of medicine for treating acute pancreatitis

A technology for acute pancreatitis and compounds, applied in the field of medicine, can solve problems such as elevation and neutropenia, and achieve the effects of simple medication, obvious therapeutic effect, important medical prospects and economic value

Active Publication Date: 2020-08-14
LINK HEALTH GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ulinastatin has common side effects such as granulocytopenia, diarrhea, skin redness and itching

Method used

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  • Application of compound in preparation of medicine for treating acute pancreatitis
  • Application of compound in preparation of medicine for treating acute pancreatitis
  • Application of compound in preparation of medicine for treating acute pancreatitis

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Embodiment 1 Therapeutic effect of compound of the present invention on acute pancreatitis in rats

[0037] (1) Experimental method

[0038] Modeling: 50 SPF grade male SD rats (212-236g) were anesthetized, skin-prepared and disinfected, and a 2-3 cm transverse incision was made in the upper abdomen at 1-2 cm below the xiphoid process. Determine the liver, stomach, and spleen, find the duodenum by following the stomach, find the pancreas between the duodenal mesentery and the spleen at the back of the stomach, and find the opening of the transparent bile-pancreatic duct and the duodenum at the opening along the inner side of the duodenum. Intestinal big nipples. The common hepatic duct was ligated with an arterial clip near the hilum, and then the needle was advanced obliquely from the side of the duodenum and the direction of the needle was adjusted so that it could enter the bile-pancreatic duct. Slowly inject 2.5% sodium taurocholate 1 mL / kg retrogradely. The speed...

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Abstract

The invention discloses an application of a compound in preparation of a medicine for treating acute pancreatitis. The compound can remarkably reduce the content of serum amylase and has an obvious effect on treating acute pancreatitis, and the curative effect of the compound is superior to or not inferior to that of an existing treatment medicine, namely ulinastatin. The compound can be used fordeveloping a novel medicine for treating acute pancreatitis, and has an important medical prospect and economic value.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the application of a compound in the preparation of medicine for treating acute pancreatitis. Background technique [0002] Acute pancreatitis is mainly due to the self-digestion of the pancreas by pancreatic enzymes and the digestion of its surrounding tissues, resulting in a series of organ dysfunction. features. There are many causes, common ones are gallstone disease, heavy drinking and overeating. The fatality rate of acute pancreatitis is about 10%, and almost all the fatal cases are the first attack. The presence of respiratory insufficiency or hypocalcemia indicates a poor prognosis. The fatality rate of severe necrotizing pancreatitis is 50% or higher, and surgical treatment can reduce it to about 20%. [0003] Most acute pancreatitis is mild acute pancreatitis, and most of them can be cured after 3 to 5 days of active treatment. One of the key steps is to reduce the secretion ...

Claims

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Application Information

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IPC IPC(8): A61K31/437A61K9/08A61P1/18
CPCA61K9/0095A61K31/437A61P1/18
Inventor 宋燕吴才梅许元生卢肖宇
Owner LINK HEALTH GRP
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