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Composition and application for treating non-alcoholic fatty liver

A non-alcoholic, fatty liver technology, applied in the field of compositions for the treatment of non-alcoholic fatty liver, can solve the problems of low solubility, insufficient research, insufficient development, etc., to regulate insulin resistance, reduce transaminases, and reduce lipid overload The effect of oxidation

Active Publication Date: 2022-02-11
THE THIRD AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the low solubility of the flavonoids in Cyclocarya paliurus, they are usually the substrates of transporters and other factors, resulting in low oral bioavailability, which is a key problem restricting the clinical application of flavonoids.
Therefore, the current research on the treatment of non-alcoholic fatty liver with the total flavonoids of Cyclocarya paliurus is not enough, and the development in the field of medicine and health care is insufficient.

Method used

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  • Composition and application for treating non-alcoholic fatty liver
  • Composition and application for treating non-alcoholic fatty liver
  • Composition and application for treating non-alcoholic fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 A preparation method of capsules for treating non-alcoholic steatohepatitis

[0033] The preparation method of the medicine for treating non-alcoholic steatohepatitis is:

[0034] 1. Take the dried leaves of Cyclocarya paliurus, put it in 10 times of the mass of medicinal materials, and soak in an ethanol solution with a volume fraction of 90% for 0.5h after crushing, then heat and reflux to extract 2 times, each time for 2h, combine the extracts, filter, reduce Concentrate under reduced pressure until no alcohol smell, extract 3 times with petroleum ether, discard the petroleum ether layer, take the water phase and add ethyl acetate to extract 3 times, combine the extracts and concentrate under reduced pressure, dry the extract to obtain a dry paste. The extract was made into a suspension with a mass concentration of 1 mg / mL with ultrapure water, added to a D101 macroporous resin column, and the ratio of sample volume to resin volume was 1:15, and washed with...

Embodiment 2

[0036] Example 2 A preparation method of capsules for treating non-alcoholic steatohepatitis

[0037] The preparation method of the medicine for treating non-alcoholic steatohepatitis is:

[0038] 1. Get the dry leaves of Cyclocarya paliurus, put it in 12 times of the mass of medicinal material after crushing, and soak it in an ethanol solution with a volume fraction of 90% for 0.5h, then heat and reflux to extract 2 times, each time for 2h, combine the extracts, filter, reduce Concentrate under reduced pressure until no alcohol smell, extract 3 times with petroleum ether, discard the petroleum ether layer, take the water phase and add ethyl acetate to extract 3 times, combine the extracts and concentrate under reduced pressure, dry the extract to obtain a dry paste. The extract was made into a suspension with a mass concentration of 1 mg / mL with ultrapure water, added to a D101 macroporous resin column, and the ratio of sample volume to resin volume was 1:15, and washed with ...

Embodiment 3

[0040] Example 3 A preparation method of capsules for treating non-alcoholic steatohepatitis

[0041] The preparation method of the medicine for treating non-alcoholic steatohepatitis is:

[0042] 1. Get the dried leaves of Cyclocarya paliurus, put it in 14 times of the mass of medicinal material after crushing, and soak in an ethanol solution with a volume fraction of 90% for 0.5h, then heat and reflux to extract 2 times, each time for 2h, combine the extracts, filter, reduce Concentrate under pressure until there is no alcohol smell, extract 3 times with petroleum ether, discard the petroleum ether layer, take the water phase and add ethyl acetate to extract 3 times, combine the extracts and concentrate under reduced pressure, dry the extract to obtain a dry paste. The extract was made into a suspension with a mass concentration of 1 mg / mL with ultrapure water, added to a D101 macroporous resin column, and the ratio of sample volume to resin volume was 1:15, and washed with ...

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Abstract

The invention belongs to the technical field of medicine, and in particular relates to a composition for treating non-alcoholic fatty liver and its application. The composition for treating non-alcoholic fatty liver provided by the invention comprises the following components and their weight percentages: 50-80% total flavonoids of Cyclocarya paliurus and 20-50% nobiletin. The composition for the treatment of non-alcoholic fatty liver provided by the present invention uses the total flavonoids of Cyclocarya caraliarius in combination with nobiletin for the first time, which has the functions of reducing transaminase, blood fat, blood sugar, lipid peroxidation, insulin resistance, etc. It can improve the effect of treating non-alcoholic fatty liver when Cyclocarya flavonoids are used alone, and can be effectively used in the preparation of non-alcoholic fatty liver drugs, which provides a great boost for the realization of a healthy China.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition for treating non-alcoholic fatty liver and its application. Background technique [0002] According to the latest WHO data, in 2016, worldwide, 39% of adults aged 18 and over were overweight (1.9 billion people), and 13% were obese (650 million people), and there were more than 340 million 5- 19-year-old children and adolescents who are overweight or obese. According to statistics in my country, in 2015, the overweight rate of adults aged 18 and over was 30.1%, and the obesity rate was 11.9%. The overweight rate of children and adolescents aged 6-17 was 9.6%, and the obesity rate was 6.4%. Elevated body mass index is a major risk factor for non-communicable diseases, such as cardiovascular disease, diabetes, tumors, etc. Weight management has increasingly become the most concerned issue in society. [0003] Non-alcoholic fatty liver disease (NAFLD) re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K36/52A61P1/16
CPCA61K36/52A61K31/352A61P1/16A61K2236/333A61K2236/39A61K2236/55A61K2300/00
Inventor 袁中文冯森玲严鹏科
Owner THE THIRD AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY
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