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Nano photosensitive compound targeting epileptic cells and regulation and control detection system

A compound and photosensitizing drug technology, which is applied to nervous system diseases, photodisintegration of drugs in the body, non-active ingredients of polymer compounds, etc. Damage and other issues, to achieve the effect of improving temporal and spatial resolution, reducing side effects, reducing dispersion and loss

Active Publication Date: 2020-08-21
AEROSPACE INFORMATION RES INST CAS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current clinical methods for the treatment of epilepsy mainly include drug therapy, surgical resection, and brain stimulation therapy, but these methods have problems such as large side effects, re-injury, and low accuracy, and lack of targeted therapy with high spatiotemporal resolution

Method used

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  • Nano photosensitive compound targeting epileptic cells and regulation and control detection system
  • Nano photosensitive compound targeting epileptic cells and regulation and control detection system
  • Nano photosensitive compound targeting epileptic cells and regulation and control detection system

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Embodiment Construction

[0042] The invention discloses a nano-targeted photosensitive compound for regulating and controlling epileptic focus nerve cells and a control and detection system, which can realize targeted regulation of nerve cells in epileptic focus areas, and at the same time can realize synchronous detection of electrophysiological signals of nerve cells under targeted control, With high spatial and temporal resolution, it provides new drugs and new methods for the treatment of epilepsy.

[0043] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with specific embodiments and with reference to the accompanying drawings.

[0044] Such as figure 1 As shown, it is a schematic diagram of the nano-targeted photosensitive complex for regulating epileptic focus nerve cells described in the embodiment of the present invention; it includes nanoliposome 1, photosensitive dr...

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Abstract

The invention relates to a nano targeting photosensitive compound. The nano targeting photosensitive compound comprises a nano liposome, a photosensitive drug wrapped in the liposome, and a targetingmolecular group connected to the outer surface of the nano liposome. The invention further discloses a preparation method of the nano targeting photosensitive compound and a regulation and control detection system established by applying the nano targeting photosensitive compound, the nano targeting photosensitive compound is high in biocompatibility, the utilization rate of the wrapped medicine is increased, and targeting regulation and control can be conducted on nerve cells in a focus area. A nerve regulation and control detection system prepared from the compound can realize nerve signal synchronous recording under targeted regulation and control, and has good space-time resolution.

Description

technical field [0001] The invention relates to the fields of biomedical basic research, targeted nano-medicine regulation and nerve signal detection, and in particular to a nano-targeted photosensitive compound for regulating epileptic focus nerve cells and a regulation and detection system established by using the same. Background technique [0002] Epilepsy is the second largest disease of the central nervous system after cerebrovascular diseases. The factors that cause epilepsy are usually complex, and different types of epilepsy have different focal areas. Epilepsy will continue to affect the patient's psychological cognition and basic physiological functions, causing serious psychological disorders and functional damage, and even death, which will bring great pressure to the patient's family and society. The current clinical methods for the treatment of epilepsy mainly include drug therapy, surgical resection, and brain stimulation therapy, but these methods have probl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K41/00A61K31/198A61K31/197A61K47/24A61K47/28A61K47/26A61K47/42A61P25/08A61B5/00A61B5/04A61N5/06
CPCA61K9/1271A61K41/0042A61K31/198A61K31/197A61K47/24A61K47/28A61K47/26A61K47/42A61P25/08A61N5/062A61B5/4094A61B5/6868A61N2005/0612A61N2005/063A61N2005/0626A61B2503/40A61B2503/42A61B5/24
Inventor 戴玉川蔡新霞宋轶琳谢精玉李轩宇王昊肖桂花郑文富蒋兴宇
Owner AEROSPACE INFORMATION RES INST CAS
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