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A method and device for constructing a geometric model of the left ventricle for evaluating the efficacy of injectable hydrogels
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A technology of geometric model and efficacy evaluation, applied in 3D modeling, medical practical experience/guidance, image analysis, etc., can solve the problem of huge cost of hydrogel efficacy
Active Publication Date: 2021-04-30
LUDONG UNIVERSITY
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However, in vivo experiments to assess the efficacy of hydrogels are costly
At present, there are relatively few studies that use geometric modeling and biocomputation methods combined with experimental data to gain an in-depth understanding of the effects of hydrogels with different stiffnesses and different volumes on the stress and thickness of the ventricular wall.
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Embodiment 1
[0065] The embodiment of the present invention provides a method for constructing a geometric model of the left ventricle for evaluating the curative effect of an injectable hydrogel, such as figure 1 As shown, the method includes:
[0066] S1: Obtain a magnetic resonance (MRI, Magnetic Resonance Imaging) image including the left ventricle.
[0067] S2: Segment the magnetic resonance image to obtain a collection of different organ tissues of the left ventricle.
[0068] S3: For each pixel, construct a three-variable quadratic polynomial volume function block on the 3×3×3 image block centered on the pixel.
[0069] In this step, the pixel P i,j,k The corresponding three-dimensional coordinates are (i, j, k), for each pixel P i,j,k , taking it as the center to divide the image block of 3×3×3, taking the step size between the pixels of the MRI image in the three directions of xyz as 1, and for each pixel P i,j,k , get a 3×3×3 image block respectively, for each pixel P i,j,k ...
Embodiment 2
[0130] The embodiment of the present invention provides a method for constructing a geometric model of the left ventricle for evaluating the curative effect of an injectable hydrogel, such as figure 2 As shown, the device includes:
[0131] The acquisition module 1 is configured to acquire a magnetic resonance image including the left ventricle.
[0132] The segmentation module 2 is configured to segment the magnetic resonance image to obtain different organ and tissue sets of the left ventricle.
[0133] The quadratic polynomial volume function block construction module 3 is used for constructing a three-variable quadratic polynomial volume function block on a 3×3×3 image block centered on the pixel for each pixel.
[0134] Cubic polynomial volume function block construction module 4, for each unit cube formed by adjacent 8 pixels, the quadratic polynomial volume function block weighted average of all pixels in the cube, to construct a three-variable cubic polynomial volume...
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Abstract
The invention discloses a method and a device for constructing a left ventricle geometric model for evaluating the curative effect of an injectable hydrogel, and belongs to the field of image processing. It includes: acquiring a magnetic resonance image including the left ventricle; segmenting the magnetic resonance image to obtain a collection of different organs and tissues of the left ventricle; for each pixel, constructing a Three-variable quadratic polynomial volume function block; on each unit cube formed by adjacent 8 pixels, weighted average of the quadratic polynomial volume function blocks of all pixels in the cube to construct a three-variable cubic polynomial volume function block; all cubic polynomial volume function blocks are combined to obtain a three-dimensional geometric model of the left ventricle. The invention provides a method for constructing a high-precision left ventricle solid model for evaluating the curative effect of the hydrogel on treating myocardial infarction, provides an effective technology for highly accurate evaluation, and provides an important auxiliary technology for medical staff to improve the curative effect of treating myocardial infarction.
Description
technical field [0001] The invention relates to the field of computer image processing, in particular to a method and a device for constructing a left ventricle geometric model for evaluating curative effect of an injectable hydrogel. Background technique [0002] Cardiovascular disease is a leading cause of death worldwide and may eventually lead to heart failure due to poor remodeling of the ventricular wall. Therefore, the material properties of the myocardium play an important role in the study of LV function in health and disease. Injectable hydrogel is a biocompatible injectable material that has shown remarkable efficacy in attenuating ventricular remodeling. A variety of hydrogels of different materials are currently being used to assess the effect on ventricular wall thickness and left ventricular function. Many in vivo experimental studies have proved that injectable hydrogel can play a certain effective role in the treatment of myocardial infarction. [0003] T...
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