Preparation method of 3D printed skin

A 3D printing and 3D printer technology, which is applied in the field of 3D printing skin preparation, can solve the problems of difficult source of raw materials, high irritation, and many scars.

Inactive Publication Date: 2020-09-22
PRINT RITE UNICORN IMAGE PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The artificial skin made by the existing method has shortcomings in different aspects and degrees during the treatment process, or the strength is too poor due to poor adhesion; or the irritation is too strong because of the antigenicity; Poor performance, easy to infect; or because it hinders the growth of autogenous body skin, scars are numerous; or because the source of raw materials is not easy, the cost is too high; or because the process is complex, manufacturing is difficult, or it is difficult to store, etc., so it cannot be well promoted and sold. Clinical application

Method used

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  • Preparation method of 3D printed skin
  • Preparation method of 3D printed skin
  • Preparation method of 3D printed skin

Examples

Experimental program
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Effect test

preparation example Construction

[0032] This embodiment provides a preparation method for 3D printed skin, which includes the following steps in sequence:

[0033] (1) 3D scanning and skin modeling: use a 3D scanner to scan the damaged part of the human skin to obtain the three-dimensional structure of the damaged part of the skin, and then use the software to calculate the properties of the fully customized skin that needs to be transplanted, including the three-dimensional base Various attributes of the model and skin structure model, establish a 3D printed skin model including a scaffold that conforms to the three-dimensional structure of the damaged skin, so that the customized skin can completely fit the wound; predict and evaluate whether stem cells are needed, and if necessary, preliminarily estimate their quantity ; Simultaneously assess the type of nutrient solution or medicine that needs to be input to promote skin regeneration, assess the structure of the microneedle, the position, layout of the mic...

Embodiment 1

[0039] Embodiment one: if figure 1 As shown, this embodiment provides a 3D printed skin, which includes an epidermal cell layer 11 , a dermal cell layer 12 , microneedles 13 and a scaffold 14 . Wherein, the first end of the microneedle 13 penetrates the surface of the epidermis cell layer 11 , and the second end penetrates the bottom surface of the dermis cell layer 12 , and a passage is provided in the middle of the microneedle 13 . The microneedle 13 includes a straight section and a tapered section. The microneedle 13 and the support 14 are made of the same material. The bracket 14 is located on the uppermost layer, and the bracket 14 can be removed after the 3D printing skin grafting operation. The 3D printed skin may also include a collagen gel layer, not shown in the figure.

Embodiment 2

[0040] Embodiment two: if figure 2 As shown, this embodiment provides a 3D printed skin, which includes an epidermal cell layer 21 , a dermal cell layer 22 , microneedles 23 and a scaffold 24 . Wherein, the microneedle 23 and the support 24 are made of different materials. The bracket 24 is located on the topmost layer of the 3D printed skin and can be removed after the 3D printed skin grafting operation. All the other structures are similar to the first embodiment.

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Abstract

The invention provides a preparation method of 3D printed skin. The 3D printed skin comprises a skin layer prepared by 3D printing, and further comprises microneedles. The preparation method comprisesthe following steps: scanning a damaged part of the skin by using a 3D scanner, obtaining attributes of the skin required by the damaged part, establishing a substrate model and a 3D printed skin model; printing the substrate by using a 3D printer; printing skin layers and a plurality of microneedles layer by layer; or printing the skin layers layer by layer, and then inserting the plurality of prepared microneedles; or placing the plurality of prepared microneedles, and printing the skin layers layer by layer; or printing the microneedles while printing the skin layers layer by layer. The preparation method can be used for preparing the 3D printed skin which is completely attached to the damaged part of the human skin and has a material conveying function.

Description

technical field [0001] The invention relates to the field of 3D printing and tissue engineering biomedical materials, in particular to a method for preparing 3D printed skin. Background technique [0002] The skin is the largest organ of the human body. It not only has the function of resisting external environmental infection, but also undertakes the task of preventing the loss of water, electrolytes and other substances in the body. Generally, if the skin is slightly damaged, the skin can restore itself. When a large area of ​​skin is severely damaged, such as a burn, doctors must immediately infuse fluids and protect the wound. In normal healthy people, new skin can regenerate if only the superficial layers of the skin are damaged, but for some patients, such as those with diabetes, the skin repair process is very difficult. In addition, if the patient suffers severe burns that affect endogenous stem cells, the skin cannot repair itself, and superficial skin from other ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/60A61L27/16A61L27/18A61L27/24A61L27/38A61L27/52A61L27/58A61M37/00B33Y10/00B33Y70/00
CPCA61L27/16A61L27/18A61L27/24A61L27/3804A61L27/3886A61L27/3895A61L27/52A61L27/58A61L27/60A61L2430/34A61M37/0015B33Y10/00B33Y70/00C08L83/04C08L89/00
Inventor 苏健强钟金淑子
Owner PRINT RITE UNICORN IMAGE PROD CO LTD
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