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Chitosan hemostatic gel and preparation method thereof

A hemostatic gel and chitosan technology, applied in the field of medical materials, can solve the problems of poor water solubility, slow hemostasis rate, and restrictions on the application of chitosan

Pending Publication Date: 2020-10-23
ZHANGJIAGANG XIANGCHENG MEDICAL MATERIAL SSCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the simple chitosan hemostatic material still has the problem of slow hemostatic rate, and its poor water solubility also restricts the application of chitosan in various complex scenarios.

Method used

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  • Chitosan hemostatic gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 10g chitosan raw material and add it into 100ml 2% sodium hydroxide solution, heat up to 50°C and soak for 1h. After weighing 10 g of tetradecyl glycidyl ether and dissolving it in a small amount of water, add it to the above reaction system, and continue to stir and react at 50° C. for 5 h. After the reaction, the solid matter was filtered out, washed with ethanol until neutral and dried to obtain modified chitosan powder. Weigh an appropriate amount of modified chitosan powder and dissolve it in water to make a solution with a mass concentration of 1.5%, to obtain the product.

Embodiment 2

[0028] Weigh 10g chitosan raw material and add it into 100ml 2% sodium hydroxide solution, heat up to 50°C and soak for 1h. After weighing 5g of decyl glycidyl ether and dissolving it in a small amount of water, add it to the above reaction system, and continue to stir and react at 50°C for 4h. After the reaction, the solid matter was filtered out, washed with ethanol until neutral and dried to obtain modified chitosan powder. Weigh an appropriate amount of modified chitosan powder and dissolve it in water to make a solution with a mass concentration of 1%, to obtain the product.

Embodiment 3

[0030] Weigh 10g chitosan raw material and add it into 100ml 2% sodium hydroxide solution, heat up to 60°C and soak for 1.5h. After weighing 12g of dodecyl glycidyl ether and dissolving it in a small amount of water, add it into the above reaction system, and continue to stir and react at 60°C for 5h. After the reaction, the solid matter was filtered out, washed with ethanol until neutral and dried to obtain modified chitosan powder. Weigh an appropriate amount of modified chitosan powder and dissolve it in water to make a solution with a mass concentration of 1.5%, to obtain the product.

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Abstract

The invention discloses a chitosan hemostatic gel and a preparation method thereof. The chitosan hydrogel is glycidyl ether modified chitosan dissolved in water. For the deficiency that the blood coagulation rate of the common chitosan material is relatively slow, a hydrophobic chitosan derivative is prepared by introducing the alkane long chain in the invention; when in contact with blood, the hydrophobic group thereof can promote erythrocyte aggregation to realize rapid blood coagulation; the chitosan hemostatic gel in the invention is the gel dosage form, which is convenient to use and carry; and the preparation method adopted in the invention is simple and convenient in process and convenient to operate, and can be used for large-scale industrial production.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a chitosan hemostatic gel and a preparation method thereof. Background technique [0002] Hemostasis is an important step in emergency medical treatment. Rapid hemostasis is required for patients undergoing surgical treatment and sudden trauma in daily life. It is particularly important to achieve rapid and effective hemostasis in harsh war environments and emergency treatment of war and trauma in complex emergencies. The hemostatic products currently sold and used in the market can be roughly divided into three categories in terms of their mechanism of action: the first category absorbs the water in the blood near the wound through the physical or chemical action of the material, and concentrates and gathers the coagulation components of the blood at the wound. Thereby accelerating blood coagulation, or the material can improve the adhesion and aggregation ability of ...

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L24/08C08B37/08
CPCA61L24/0031A61L24/08A61L2400/04C08B37/003C08L5/08
Inventor 赵铭袁飞
Owner ZHANGJIAGANG XIANGCHENG MEDICAL MATERIAL SSCI & TECH CO LTD
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