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High-fat and high-sugar diet induced dry age-related macular degeneration pigment rabbit model

A macular degeneration and correlation technology, applied in the direction of additional food elements, preparations for in vivo experiments, compound screening/testing, etc., can solve the problems of cumbersome manual perfusion operations and long cycles

Pending Publication Date: 2020-11-03
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its cycle is long, manual perfusion operation is cumbersome, not suitable for industrial application

Method used

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  • High-fat and high-sugar diet induced dry age-related macular degeneration pigment rabbit model
  • High-fat and high-sugar diet induced dry age-related macular degeneration pigment rabbit model
  • High-fat and high-sugar diet induced dry age-related macular degeneration pigment rabbit model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1 Model Construction

[0045] 1. Method

[0046] 1.1 Modeling

[0047] Divide 12-16-week-old adult male qingzilan rabbits with a body weight of 3.5±0.5kg into two groups, each with 12 rabbits. The control group (ND) was fed rabbit maintenance feed (Beijing Keao Xieli Feed Co., Ltd.), and the high-fat and high-sugar group (HFSD) are fed high-fat and high-sugar feed, and the amount of feeding is 40-60g in the morning and 60-90g in the afternoon.

[0048] The nutritional ingredients of the maintenance feed: 23.5% (w / w) protein, 11% (w / w) fat, 65.5% (w / w) carbohydrate; energy: 2.7kcal / g.

[0049] The high-fat and high-sugar feed is based on the maintenance feed by adding 10% lard, 35% sucrose and 0.5% cholesterol by weight.

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Abstract

The invention discloses a construction method of a high-fat and high-sugar diet induced dry age-related macular degeneration pigment rabbit model, and belongs to the field of ophthalmic disease animalmodels. The construction method comprises the steps: 10% of lard oil, 35% of sucrose and 0.5% of cholesterol in percentage by weight are added into maintenance feed for chinchilla rabbits, and chinchilla rabbits are continuously fed for 24 weeks. According to the construction method, animals can generate symptoms of dry age-related macular degeneration only by diet control, and the construction method is simple and convenient, and is easy for industrial application.

Description

technical field [0001] The invention belongs to the field of ophthalmic disease animal models. Background technique [0002] Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in people over 50 years old in developed regions. Due to the aging population in China, AMD has also become an important blinding eye disease. Because the pathogenesis is unclear, it has always been the focus and difficulty of ophthalmology clinical work. AMD is divided into dry (atrophic) and wet (exudative) AMD based on clinicopathological features, the former characterized by early drusen, retinal pigment epithelial (RPE) changes, and late geographic atrophy involving the center of the macula; the latter Those are characterized by choroidal neovascularization (CNV). Dry AMD can also develop into wet AMD in the later stage, which seriously damages the vision of patients. Clinically, about 90% of patients are dry AMD. Although great progress has been made in the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/027A61K49/00A23K20/158A23K20/163A23K20/168A23K50/00
CPCA01K67/027A01K2207/25A01K2227/107A01K2267/03A61K49/0008A23K20/158A23K20/163A23K20/168A23K50/00
Inventor 王钰娇陈大年
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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