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High-sugar diet induced early-stage dry age-related macular degeneration pigment rabbit model

A macular degeneration and correlation technology, applied in the direction of additional food elements, preparations for in vivo experiments, compound screening/testing, etc., can solve the problems of long cycle time and cumbersome manual perfusion operations

Inactive Publication Date: 2020-11-27
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its cycle is long, manual perfusion operation is cumbersome, not suitable for industrial application

Method used

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  • High-sugar diet induced early-stage dry age-related macular degeneration pigment rabbit model
  • High-sugar diet induced early-stage dry age-related macular degeneration pigment rabbit model
  • High-sugar diet induced early-stage dry age-related macular degeneration pigment rabbit model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 Model Construction

[0044] 1. Method

[0045] 1.1 Modeling

[0046] The 16-week-old adult male cyanotic blue rabbits with a body weight of 3.5±0.5kg were divided into two groups, each with 10 rabbits. Feeding high-sugar feed, the amount of feeding every day is 40-60g in the morning and 60-90g in the afternoon.

[0047] The nutritional composition of the maintenance feed: 23.5% (w / w) protein, 11% (w / w) fat and 65.5% (w / w) carbohydrate; energy: 2.7kcal / g.

[0048] The high-sugar feed is based on the maintenance feed with 40% sucrose added by weight.

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Abstract

The invention discloses a construction method of a high-sugar diet induced early-stage dry age-related macular degeneration pigment rabbit model, and belongs to the field of ophthalmic disease animalmodels. The method disclosed by the invention comprises the following steps of: adding 40% by weight of cane sugar into maintenance feed for blue-violet blue rabbits, and continuously feeding the blue-violet blue rabbits for 24 weeks. According to the method disclosed by the invention, animals can generate age-related macular degeneration symptoms only by diet control; and the method is simple andconvenient and is easy for industrial application.

Description

technical field [0001] The invention belongs to the field of ophthalmic disease animal models. Background technique [0002] Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in people over 50 years old in developed regions. Due to the aging population in China, AMD has also become an important blinding eye disease. Because the pathogenesis is unclear, it has always been the focus and difficulty of ophthalmology clinical work. AMD is divided according to the stage of onset into early AMD and late AMD, the former is characterized by early drusen, retinal pigment epithelium (RPE) and photoreceptor cell changes, that is, dry (atrophic) AMD, which can also progress to choroidal neovascularization (CNV), wet (exudative) AMD; advanced AMD characterized by geographic atrophy involving the center of the macula. About 90% of patients are clinically dry AMD. Although great progress has been made in the diagnosis and treatment of wet AMD (such as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/02A61K49/00A23K20/147A23K20/158A23K20/163A23K50/00
CPCA01K67/02A01K2207/25A01K2227/107A01K2267/0375A61K49/0008A23K20/147A23K20/158A23K20/163A23K50/00
Inventor 王钰娇
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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