Application of ellagic acid metabolite urolithin A in the preparation of anti-enteroviral drugs

An enterovirus and drug technology, applied in the direction of antiviral agents, resistance to vector-borne diseases, pharmaceutical formulations, etc., can solve the problem of no relevant research reports on antiviral effects
CN111939152BActive Publication Date: 2021-08-03ZUNYI MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZUNYI MEDICAL UNIVERSITY
Publication Date
2021-08-03

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Abstract

The application discloses the application of ellagic acid metabolite Urolithin A in the technical field of pharmaceutical preparations in the preparation of anti-enterovirus drugs, especially the application in the preparation of drugs for preventing and treating enterovirus 71 (Enterovirus 71, EV71). The present invention shows that Urolithin A can inhibit the replication of EV71 at gene and protein levels through the influence of UroA on EV71 virus titer and EV71 protein expression. It is proved that the Urolithin A has obvious anti-EV71 effect and can be used to prepare anti-EV71 medicine.
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Description

technical field

[0001] The technical field of pharmaceutical preparations of the present invention particularly relates to the application of ellagic acid metabolite Urolithin A in the preparation of anti-enterovirus drugs. Background technique

[0002] Hand, foot, and mouth disease (HFMD) is a common infectious disease in children worldwide caused by human enterovirus (HEV), with a high incidence in children under 5 years old. HFMD is mostly a self-limiting disease, accompanied by symptoms such as fever, rash on hands and feet, and oral herpes. However, in some patients, the disease progresses rapidly, which can lead to severe pulmonary edema, neurological and systemic complications, and even death. Enterovirus 71 (human enterovirus 71, EV71), a member of HEV, is a single-stranded positive-sense RNA virus belonging to the family Picornaviridae, and is the main pathogen that causes severe and fatal cases of HFMD. Since 1997, HFMD has broken out in the Asia-Pacific region. ...

Claims

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