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Therapeutic agents for pancreatic cancer

a technology for pancreatic cancer and compositions, applied in drug compositions, antibody medical ingredients, peptides, etc., can solve the problems of not achieving significant improvement in the extended survival rate of pancreatic cancer patients, rapid progress, and poor prognosis, so as to achieve excellent therapeutic effect against pancreatic cancer and reduce metastatic lesions from human pancreatic cancer

Inactive Publication Date: 2016-01-28
NAT CANCER CENT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0029]An excellent therapeutic effect against pancreatic cancer was obtained by using an IL-6 inhibitor and an antimetabolite in combination. Moreover, it was shown that metastatic lesions from human pancreatic cancer can be reduced and ascites can be eliminated by the combination described above. Especially, there has been no report that ascites is eliminated by monotherapy.

Problems solved by technology

It is also used as a combination therapy with radiotherapy, but has not achieved significant improvement in extended survival of pancreatic cancer patients.
Some attempts have been made for other effective combination therapies, but any improvement in survival rate has not been reported.
Pancreatic cancer is diagnosed at unresectable advanced stages in many cases even today, and associated with rapid progress and very poor prognosis.
Even cases having undergone the only possible cure resection often lead to early recurrence after operation.
On the other hand, chemotherapy is indicated for unresectable cases with good performance status (PS) and major organ function, but even the current standard of care does not have sufficient therapeutic effect.

Method used

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  • Therapeutic agents for pancreatic cancer
  • Therapeutic agents for pancreatic cancer
  • Therapeutic agents for pancreatic cancer

Examples

Experimental program
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Effect test

example 1

Effect of Combined Administration of Gemcitabine Hydrochloride and Tocilizumab on Pancreatic Cancer

[0140]A chemotherapy-naive patient having progressive / metastatic pancreatic cancer and showing CRP>=2.0 mg / dL (CRP: C-reactive protein that correlates with the intensity of inflammatory response) was treated with gemcitabine hydrochloride and a humanized IL-6 receptor antibody (tocilizumab).

[0141]A male at age 72 with no history of smoking having pancreatic body cancer of Stage W as defined by the TNM classification of UICC1) had metastatic lesions in the liver, lymph nodes, ascites and peritoneum and had evident ascites as shown in FIG. 1. This case had a CRP of 3.28 mg / dL immediately before administration and also suffered from hyperlipidemia and chronic atrophic gastritis as complications. This patient was treated with gemcitabine hydrochloride and tocilizumab in combination. Gemcitabine hydrochloride was administered by intravenous drip injection at 1000 mg / m2 expressed as gemcitab...

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Abstract

We achieved the present invention on the basis of the finding that an excellent therapeutic effect against pancreatic cancer can be obtained by administering an IL-6 inhibitor and an antimetabolite to pancreatic cancer patients. We also found that metastatic lesions from human pancreatic cancer can be reduced and ascites can be eliminated.

Description

TECHNICAL FIELD[0001]The present invention relates to therapeutic compositions for pancreatic cancer. More specifically, the present invention relates to therapeutic compositions for pancreatic cancer comprising an interleukin 6 (IL-6) inhibitor, said compositions further comprising or being administered in combination with an antimetabolite.BACKGROUND ART[0002]IL-6 is a cytokine also called B cell stimulating factor 2 (BSF2) or interferon β2. IL-6 was discovered as a differentiation factor involved in the activation of B lymphocytes (non-patent document 1), and then demonstrated to be a multifunctional cytokine that influences functions of various cells (non-patent document 2). IL-6 has been reported to induce maturation of T lymphocytes (non-patent document 3).[0003]IL-6 mediates its biological activities through two proteins on cells. One is the IL-6 receptor that is a ligand-binding protein having a molecular weight of about 80 kD to which IL-6 binds (non-patent document 4, non-...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K39/395A61K31/7068
CPCA61K39/3955A61K2039/505A61K31/7068A61K45/06C07K16/2866C07K2317/24A61P1/18A61P35/00A61P43/00A61K2300/00
Inventor MITSUNAGA, SHUICHIOCHIAI, ATSUSHIIKEDA, MASAFUMI
Owner NAT CANCER CENT
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