Preparation method of anti-tumor drug microcapsules

A technology for anti-tumor drugs and microcapsules, applied in the directions of anti-tumor drugs, microcapsules, and capsule delivery, can solve the problems of poor emulsifying ability, poor film-forming properties, large molecular weight, etc. good fluidity

Inactive Publication Date: 2020-11-17
嘉兴市爵拓科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] As a microcapsule wall material, starch has some shortcomings in structure and performance, such as too large molecular weight, easy aging, poor film-forming property, poor emulsifying ability, etc., which limit its application as a carrier.

Method used

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  • Preparation method of anti-tumor drug microcapsules
  • Preparation method of anti-tumor drug microcapsules
  • Preparation method of anti-tumor drug microcapsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A preparation method of antineoplastic drug microcapsules,

[0031] (1) Preparation of caffeoyl tartaric acid starch ester: dissolve caffeoyl tartaric acid in ethanol solution, adjust pH to 3 to obtain caffeoyl tartaric acid ethanol solution, add starch to caffeoyl tartaric acid ethanol solution, stir and mix evenly, Stand at high temperature for 12 hours, dry in an oven, crush after drying, and stand at 130°C for 3 hours. After the reaction, wash, dry, dry, and crush to obtain caffeoyl tartaric acid starch ester; the amount of starch added is 25wt %, the added amount of caffeoyl tartaric acid is 20wt% of starch.

[0032] (2) Preparation of antineoplastic drug microcapsules: adding caffeoyl tartrate starch ester and sodium alginate to an aqueous ethanol solution to prepare a wall material solution, adding antineoplastic drug paclitaxel and gelatin emulsifier to the wall material solution, at 30°C Homogenized at high temperature for 30 minutes to obtain the wall core mi...

Embodiment 2

[0034] A preparation method of antineoplastic drug microcapsules,

[0035] (1) Preparation of caffeoyl tartaric acid starch ester: dissolve caffeoyl tartaric acid in ethanol solution, adjust pH to 3 to obtain caffeoyl tartaric acid ethanol solution, add starch to caffeoyl tartaric acid ethanol solution, stir and mix evenly, Stand at high temperature for 12 hours, dry in an oven, crush after drying, and stand at 130°C for 3 hours. After the reaction, wash, dry, dry, and crush to obtain caffeoyl tartaric acid starch ester; the amount of starch added is 25wt %, the added amount of caffeoyl tartaric acid is 60wt% of starch.

[0036] (2) Preparation of antineoplastic drug microcapsules: adding caffeoyl tartrate starch ester and sodium alginate to an aqueous ethanol solution to prepare a wall material solution, adding antineoplastic drug paclitaxel and gelatin emulsifier to the wall material solution, at 30°C Homogenized at high temperature for 30 minutes to obtain the wall core mi...

Embodiment 3

[0038] A preparation method of antineoplastic drug microcapsules,

[0039](1) Preparation of caffeoyl tartaric acid starch ester: dissolve caffeoyl tartaric acid in ethanol solution, adjust pH to 3 to obtain caffeoyl tartaric acid ethanol solution, add starch to caffeoyl tartaric acid ethanol solution, stir and mix evenly, Stand at high temperature for 12 hours, dry in an oven, crush after drying, and stand at 130°C for 3 hours. After the reaction, wash, dry, dry, and crush to obtain caffeoyl tartaric acid starch ester; the amount of starch added is 25wt %, the added amount of caffeoyl tartaric acid is 60wt% of starch.

[0040] (2) Preparation of antineoplastic drug microcapsules: adding caffeoyl tartrate starch ester and sodium alginate to an aqueous ethanol solution to prepare a wall material solution, adding antineoplastic drug paclitaxel and gelatin emulsifier to the wall material solution, at 30°C Homogenized at high temperature for 30 minutes to obtain the wall core mix...

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Abstract

The invention discloses a preparation method of anti-tumor drug microcapsules, which belongs to the field of pharmaceutical materials. Caffeoyl tartaric acid starch ester and sodium alginate are adopted as wall materials to prepare the anti-tumor drug microcapsules. The caffeoyl tartaric acid starch ester is prepared by dissolving caffeoyl tartaric acid in an ethanol solution; adjusting the pH value to 1-5 to obtain a caffeoyl tartaric acid ethanol solution; adding starch into the caffeoyl tartaric acid ethanol solution; uniformly stirring and mixing; allowing the mixture to stand for 6-18 hours at the temperature of 10-40 DEG C; drying in a drying oven; crushing after drying; reacting for 1-6 hours at the temperature of 110-160 DEG C, and washing, drying, drying and crushing to obtain thecaffeoyl tartaric acid starch ester. The microcapsules provided by the invention have a high embedding rate of the antitumor drug paclitaxel, and the embedding rate at least reaches 80%.

Description

technical field [0001] The invention belongs to the field of pharmaceutical materials, and in particular relates to a method for preparing antitumor drug microcapsules. Background technique [0002] Paclitaxel is a tetracyclic diterpenoid secondary metabolite extracted from Taxus plant tissue, which inhibits the proliferation and metastasis of various tumor cells and triggers significant apoptosis by promoting microtubule polymerization and stabilizing the polymerized microtubules. It is mainly used in the treatment of tumor diseases such as breast cancer, ovarian cancer and colon cancer. Because paclitaxel is poorly soluble in water, polyoxyethylene castor oil and absolute ethanol are used for intravenous injection after dissolving in clinical practice. After administration, there are severe allergic reactions and many toxic side effects, such as bone marrow suppression, neurotoxicity, cardiotoxicity, joint or Adverse reactions such as muscle pain, liver toxicity, and kidn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B31/04A61K9/52A61K31/337A61K47/36A61K47/42A61K47/22A61K47/26A61P35/00
CPCA61K9/5015A61K9/5036A61K9/5057A61K31/337A61P35/00C08B31/04
Inventor 不公告发明人
Owner 嘉兴市爵拓科技有限公司
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