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Anti-folate receptor 1 antibodies and uses thereof
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An antibody, monoclonal antibody technology, applied in the direction of antibody, anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, anti-tumor drugs, etc., can solve the problem of low expression level
Active Publication Date: 2020-11-17
PHANES BIOPHARMACEUTICALS LTD
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Abstract
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FOLR1 has become a target in oncology because it is overexpressed in certain solid tumors such as ovarian, lung and breast cancers (Toffoli et al., Int J Cancer 1997;74:193-198 and Boogerd et al., Oncotarget 2016;7: 17442-17454), but at low levels in limited normal human tissues (Weitman et al., Cancer Res 1992; 52:3396-3401)
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[0242] The invention provides the following non-limiting embodiments.
[0244] a. SEQ ID NO: 38, 39, 40, 62, 63 and 64, respectively;
[0245] b. SEQ ID NO: 17, 18, 19, 41, 42 and 43, respectively;
[0246] c. SEQ ID NO: 20, 21, 22, 44, 45 and 46, respectively;
[0247] d. SEQ ID NO: 23, 24, 25, 47, 48 and 49, respectively;
[0248] e. SEQ ID NO: 26, 27, 28, 50, 51 and 52, respectively;
[0249] f. SEQ ID NO: 29, 30, 31, 53, 54 and 55, respectively;
[0250]g. SEQ ID NO: 32, 33, 34, 56, 57 and 58, respectively; or
[0251] h. SEQ ID NO: 35, 36, 37, 59, 60 and 61, respectively;
[0252] Wherein the antibody or antigen-binding fragment thereof specifically binds to FOLR1, preferably human FOLR1.
Embodiment approach 2
[0253] Embodiment 2 is an isolated monoclonal antibody or antigen-binding fragment thereof comprising heavy chaincomplementarity determining region 1 (HCDR1), HCDR2, HCDR3, light chain complementarity determining region 1 (LCDR1), LCDR2 and LCDR3, which has the following Peptide sequence:
[0254] a. SEQ ID NO: 86, 87, 88, 110, 111 and 112, respectively;
[0255] b. SEQ ID NO: 65, 66, 67, 89, 90 and 91, respectively;
[0256] c. SEQ ID NO: 68, 69, 70, 92, 93 and 94, respectively;
[0257] d. SEQ ID NO: 71, 72, 73, 95, 96 and 97, respectively;
[0258] e. SEQ ID NO: 74, 75, 76, 98, 99 and 100, respectively;
[0259] f. SEQ ID NO: 77, 78, 79, 101, 102 and 103, respectively;
[0260] g. SEQ ID NO: 80, 81, 82, 104, 105 and 106, respectively; or
[0261] h. SEQ ID NO: 83, 84, 85, 107, 108 and 109, respectively;
[0262] Wherein the antibody or antigen-binding fragment thereof specifically binds to FOLR1, preferably human FOLR1.
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Abstract
Anti-FOLR1 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.
Description
[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Application No. 62 / 642,213, filed March 13, 2018, the entire disclosure of which is incorporated herein by reference. [0003] field of invention [0004] The present invention relates to monoclonal anti-folate receptor 1 (FOLR1) antibody, nucleic acid and expression vector encoding the antibody, recombinant cells containing the vector and compositions containing the antibody. Also provided are methods of making the antibodies, and methods of using the antibodies to treat diseases including cancer. [0005] References to Sequence Listings Submitted Electronically [0006] This application contains a sequence listing, which is electronically submitted through EFS-Web as a sequence listing in ASCII format, the file name is "689204-11WO Sequence Listing (689204-11WO Sequence Listing)", and the creation date is March 6, 2019 , the size is 64kb, and the sequence listing su...
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