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Preparation method of fructus cannabis extract

A technology of hemp seed and extract, which is applied in the field of preparation of hemp seed extract, can solve the problems of poor stability of the extract, increase of oil pressing equipment, failure of extraction and utilization of hemp seed oil, etc., and achieve improved stability and bioavailability, improve inclusion efficiency, and improve the effect of sticking to the wall

Pending Publication Date: 2020-11-24
GUANGZHOU XIANGXUE PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hemp seed is directly extracted by water, and the hemp seed oil cannot be fully extracted and utilized, and the cream yield is low, and the amount of extract is small; while the method of first pressing the oil and then water extraction, although the hemp seed oil can be collected first, it needs to increase Oil extraction equipment (increased cost), increased process (time-consuming), and the extracted oil needs to be further processed before it can be mixed with the extract, otherwise the stability of the extract is poor and it is easy to oil
In addition, the hemp seed water extract is directly spray-dried, and the spray-dried powder is easy to stick to the wall, resulting in a large loss of the spray-dried powder and a low yield of the spray-dried powder, so that the whole extraction process has a low paste rate.

Method used

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  • Preparation method of fructus cannabis extract
  • Preparation method of fructus cannabis extract
  • Preparation method of fructus cannabis extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A preparation method of hemp seed extract, such as figure 1 shown, including the following steps:

[0028] (1) make hemp seed decoction pieces the coarsest powder (the coarsest powder of Pharmacopoeia regulation refers to that can all pass through No. 1 sieve, but be mixed with the powder that can pass through No. 3 sieve and be no more than 20%);

[0029] (2) Put the coarsest powder of hemp seed and water 8 times of its weight into the extraction tank, and dissolve the β-cyclodextrin of 2% of the weight of the coarsest powder of hemp seed in the purified water of 10 times its weight and make it Put the β-cyclodextrin solution into the extraction tank together, and extract with dynamic stirring at a stirring speed of 20 to 50 rpm, and keep decocting with slight boiling (it should be noted that: decocting with slight boiling is a routine operation in the extraction of traditional Chinese medicine. Those skilled in the art can keep slightly boiling) for 2 hours, and filt...

Embodiment 2

[0034] A preparation method of hemp seed extract, comprising the following steps:

[0035] (1) the hemp seed decoction pieces are made into the coarsest powder;

[0036] (2) Put the coarsest powder of hemp seed and water 8 times of its weight into the extraction tank, and dissolve the β-cyclodextrin of 10% of the weight of the coarsest powder of hemp seed in purified water of 20 times its weight to make Put the β-cyclodextrin solution together into the extraction tank, stir and extract dynamically at a stirring speed of 20-50 rpm, keep boiling for 2 hours, filter while hot, and obtain the first extract and dregs;

[0037] (3) Put 6 times the weight of medicinal dregs and the coarsest powder of hemp seed into the extraction tank, stir and extract dynamically at a stirring speed of 20-50 rpm, keep boiling for 1.5 hours, and filter while hot to obtain the second extract;

[0038] (4) The first extract and the second extract are combined, centrifuged, and the rotating speed of t...

Embodiment 3

[0041] A hemp seed-derived preparation, the active ingredient of which is the hemp seed extract prepared in embodiment 1 or embodiment 2.

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Abstract

The invention relates to the technical field of traditional Chinese medicine extraction, and discloses a preparation method of a fructus cannabis extract. The preparation method comprises the following steps: preparing fructus cannabis decoction pieces into coarsest powder, putting the coarsest powder and water with the weight being 6-12 times that of the coarsest powder into an extraction tank, adding beta cyclodextrin with the weight being 2-10% of that of the coarsest powder of fructus cannabis into water with the weight being 5-20 times that of the coarsest powder of fructus cannabis to prepare a beta cyclodextrin solution, dynamically stirring, keeping micro-boiling decoction for 0.5-3h, and filtering to obtain a first extracting solution and medicine residues; putting the medicine residues and water with the weight being 5-12 times that of the coarsest powder of fructus cannabis into the extraction tank, dynamically stirring, keeping micro-boiling decoction for 0.5-3h, and filtering to obtain a second extracting solution; combining the two extracting solutions, and centrifuging to obtain a centrifugate; and carrying out low-temperature reduced pressure concentration on the centrifugate until the relative density is 1.05-1.15, measuring the relative density at 60 DEG C, and carrying out spray drying or belt drying to obtain the fructus cannabis extract. According to the preparation method, water-soluble substances of fructus cannabis can be effectively extracted, and fat-soluble components can be effectively extracted, so that a complex process of oil pressing and theninclusion is avoided, and the process is effective, simple and feasible and is suitable for large-scale production.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine extraction, in particular to a preparation method of hemp seed extract. Background technique [0002] Hempseed is the dry and mature seed of the Moraceae plant hemp, also known as pockmark kernel, hemp seed, hemp, white pockmark, winter pockmark, etc., widely distributed in Northeast China, North China, South China and other places. Modern research shows that hemp seed is rich in nutrition, rich in protein, oil and dietary fiber, and has good effects of lowering blood fat, anti-inflammation, anti-oxidation, and improving memory. Hemp seed oil is the oil extract of hemp seed, and its content is as high as more than 50% in hemp seed. Hemp seed oil contains a large amount of unsaturated fatty acids, which has the effects of lowering blood fat, anti-oxidation, and improving memory. [0003] At present, the preparation method of the water extract of hemp seed is mostly prepared b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61K47/69A61P25/28A61P3/06A61P39/06A61P29/00A61K131/00
CPCA61K36/60A61K47/6951A61P25/28A61P3/06A61P39/06A61P29/00A61K2236/331A61K2236/53A61K2236/51
Inventor 陈桂生黄燕明肖国梁周晓富詹智洪康志英王艳慧
Owner GUANGZHOU XIANGXUE PHARMA CO LTD
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