Application of geraniin to preparation of medicine for restraining novel coronaviruses

A technology of geraniin and coronavirus, applied in antiviral agents, pharmaceutical formulas, medical preparations containing active ingredients, etc., to achieve the effect of inhibiting proliferation and expanding the scope of application

Active Publication Date: 2020-12-04
ZHEJIANG CENT FOR DISEASE CONTROL & PREVENTION
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  • Abstract
  • Description
  • Claims
  • Application Information

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[0006] However, there is no relevant report on the use of

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  • Application of geraniin to preparation of medicine for restraining novel coronaviruses

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Embodiment 1

[0024] In this example, by measuring the viral load of SARS-CoV-2 in the infected cells after the action of the traditional Chinese medicine monomer geraniin, and comparing it with the viral load in the infected cells without drug treatment, the evaluation of the traditional Chinese medicine monomer geraniol The inhibitory ability of geraniin on the replication of SARS-CoV-2 in Vero cells, so as to study the anti-SARS-CoV-2 effect of traditional Chinese medicine monomer geraniin at the cellular level.

[0025] The geraniin (20mg / mL) used in this example was purchased from Chengdu Durst Company; the SARS-CoV-2 strain ZJ001 used was a sample from a patient with new coronary pneumonia in 2019 from the Zhejiang Provincial Center for Disease Control and Prevention. isolated from , the virus titer was 10 4 / 0.1mL; the Vero cells used were purchased from ATCC cell bank, and the generation number was less than 150 generations.

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Abstract

The invention discloses an application of geraniin to preparation of a medicine for restraining novel coronaviruses. The geraniin is applied to treatment of infection caused by the novel coronavirusesfor the first time, and through research, the inventor finds that the geraniin can effectively inhibit proliferation of the novel coronaviruses in cells, so that the geraniin can be used for treatingpneumonia diseases caused by infection of the novel coronaviruses. Therefore, the application range of the geraniin is expanded, and a new thought is provided for prevention and treatment of the novel coronaviruses. Through research, the inventor finds that 12.5-100 [mu] g/mL of the geraniin can effectively inhibit proliferation of SARS-CoV-2 in cells. Compared with virus infected cells (virus control group) which are not treated by any medicines, after the virus infected cells are treated by 100[mu]g/mL of the geraniin for 48 hours, the intracellular SARS-CoV-2 virus load is averagely reduced by 8.66 * 10<2> times.

Description

technical field [0001] The invention belongs to the technical field of novel coronavirus treatment, and in particular relates to the application of geraniin in the preparation of anti-new coronavirus drugs. Background technique [0002] People infected with pneumonia of unknown cause in 2019 will have symptoms of varying degrees, ranging from fever or mild cough to severe pneumonia and death. After testing, the infectious pneumonia of unknown cause was caused by a new coronavirus infection. In February 2020, the Coronavirus Research Group (CSG) of the International Committee on Taxonomy of Viruses officially named the new coronavirus SARS-CoV-2. [0003] During 2019-2020, SARS-CoV-2 broke out into a global pandemic. Since the discovery of the new coronavirus, various scientific research institutes and organizations around the world have actively and rapidly carried out in-depth research, hoping to find or develop drugs that can treat the new coronavirus SARS-CoV-2 infection...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P31/14
CPCA61K31/7048A61P31/14
Inventor 徐昌平冯燕高见葛琼卢亦愚吴卓颖张云怡
Owner ZHEJIANG CENT FOR DISEASE CONTROL & PREVENTION
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