The preparation method of sodium hyaluronate gel

Abstract

The invention relates to a preparation method of sodium hyaluronate gel. The method comprises that a central control unit adjusts the rotational speed of a motor to control the particle size of the pasty gel, and the central control unit controls the rotation angle of a valve to control the volume of the first dialysate. The duration of dialysis, the central control unit receives the detection data of the pH detector and the osmotic pressure detection device in real time, the central control unit controls and receives the data of the first air bubble detection device to adjust the suction speed of the vacuum pump, and the central control unit receives the data of the second air bubble detection device Adjust the speed of the centrifuge, and the central control unit is connected with the bacteria detection sensor; the central control unit can be adjusted according to the actual detection data parameters during the preparation process, so that the preparation process of sodium hyaluronate gel is efficient, and the calculation is based on the second bubble strength. If the strength of the output sodium hyaluronate gel does not match the target strength of the sodium hyaluronate gel, it can be adjusted in real time, thereby changing the strength of the output sodium hyaluronate gel.

Description

Technical field[0001]The present invention relates to the field of biomedical materials, and more particularly to a method of preparing a hyaluronate gel.Background technique[0002]Sodium hyaluronate is a natural linear polytegan, which is composed of a double sugar structural unit. A wide range of mammalian connective tissue, clamping of the chicken and streptococci, because there is no specifically and organ specificity, the hyaluronic acid gel particles obtained by transparent acid sodium sodium sue by cross-linking Filler transplantation or injection body exhibits good body biocompatibility, and has a role of anti-wrinkle feeding cushion, and has no side effects on the human body, and is widely used in medical beauty industry.[0003]Among them, in the process of preparing hyaluronic acid gel particles, under the premise of clarifying the reactants and crosslinking agents, the main factors affecting crosslinking include the ratio of crosslinking agents and hyaluronic acid usage, an...

AI Technical Summary

Problems solved by technology

[0005] Most of the sodium hyaluronate gel facial filling products on the market today are biphasic products, but biphasic products cannot be used as a safe and effective mid-face filler, because there is not much bone support in the mid-face, and the fullness of the tissue is also low. Not enough, so in order to make the face more three-dimensional, mid-face fillers are required. Due to their poor cohesion, biphasic products make these fillers not effective against tissue pressure, and over time, the products tend to be in the Diffusion / migration in adipose tissue, so there are potential risk factors, and the shaping effect is not good, and its scope of application is mainly for superficial skin wrinkle repair

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