Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Biomarker for evaluating therapeutic effect of esophageal squamous cell carcinoma (ESCC) neoadjuvant chemoradiotherapy (nCRT)

A therapeutic effect evaluation and biomarker technology, applied in the biological field, can solve the problems of increasing postoperative complications, long survival time of patients, and different

Inactive Publication Date: 2021-01-08
CHANGZHOU NO 2 PEOPLES HOSPITAL
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, patients often have disease recurrence after surgery
At the same time, the prognosis of nCRT is also different, and patients who respond to nCRT survive longer, while patients who do not respond have a worse prognosis
Importantly, nCRT may increase postoperative complications and clinical parameters (TNM grade, tumor location) do not predict response to nCRT

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biomarker for evaluating therapeutic effect of esophageal squamous cell carcinoma (ESCC) neoadjuvant chemoradiotherapy (nCRT)
  • Biomarker for evaluating therapeutic effect of esophageal squamous cell carcinoma (ESCC) neoadjuvant chemoradiotherapy (nCRT)
  • Biomarker for evaluating therapeutic effect of esophageal squamous cell carcinoma (ESCC) neoadjuvant chemoradiotherapy (nCRT)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Materials and methods

[0032] Data sources and data preprocessing.

[0033] First, the gene expression profile GSE45670 and the miRNA expression profile GSE59974 were downloaded from the Gene Expression Omnibus (GEO). These two sets of data were from the same clinical sample, including 17 ESCC non-responders and 11 ESCC responders. The GSE45670 dataset was detected on the hg-u133+u2 Affymetrix human genome u133+2.0 platform, and the GSE45670 dataset was analyzed on the Agilent-038169 human miRNA virus v18.0 platform.

[0034] In addition, biopsies were taken from 4 cases of cancer tissue before and after nCRT in Changzhou Second People's Hospital affiliated to Nanjing Medical University. This study was approved by the Hospital Ethics Research Committee. Transcriptomics data (accession number GSE13786, https: / / www.ncbi.nlm.nih.gov / geo / query / acc.cgi?acc=GSE137867), and mRNA expression analysis was performed on these clinical specimens. GSE137867 is considered as the ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a biomarker for evaluating the therapeutic effect of esophageal squamous cell carcinoma (ESCC) neoadjuvant chemoradiotherapy (nCRT) and application of an MMP12 protein as the biomarker in preparation of a reagent, kit or detection device for evaluating the rapeutic effect of ESCC nCRT. The abnormal expression level of MMP12 is significantly related to TNM staging, lymph node metastasis and survival time (P is less than 0.05) of ESCC, a new biomarker for predicting nCRT response of an ESCC patient is determined through microarray data analysis, and the MMP12 may be a useful tumor biomarker and a treatment target for the ESCC patient.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a biomarker for evaluating the curative effect of neoadjuvant radiotherapy and chemotherapy for esophageal cancer. Background technique [0002] Most patients with late diagnosis of esophageal cancer have a poor prognosis. Once metastasis occurs, the 5-year survival rate will drop to 4%. For locally advanced ESCC, preoperative neochemoradiation (nCRT) is the main component of treatment. However, patients often have disease recurrence after surgery. At the same time, the prognosis of nCRT is also different. Patients who respond to nCRT have a longer survival time, while patients who do not respond have a worse prognosis. Importantly, nCRT may increase postoperative complications, and clinical parameters (TNM grade, tumor location) cannot predict response to nCRT. Therefore, the management of ESCC will be facilitated by identifying novel biomarkers to predict nCRT response. In addi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/574
CPCC12Q1/6886C12Q2600/106C12Q2600/112C12Q2600/158C12Q2600/178G01N33/57407G01N33/57484
Inventor 汪建林朱宏明尹丽陈杰
Owner CHANGZHOU NO 2 PEOPLES HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com