Detection system and detection method for correcting the influence of anemia on glycosylated hemoglobin measurement

A glycated hemoglobin and detection system technology is applied in the field of detection systems that can correct the influence of anemia on the measured value of glycated hemoglobin, can solve problems such as inaccurate measurement results, and achieve the effects of simple operation, convenient transportation and storage, and clinical significance.

Active Publication Date: 2022-07-01
QINGDAO HIGHTOP BIOTECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] From the comparison of the above data, it can be seen that anemia has a great influence on the measurement of clinical HbA1c level, but in actual clinical work, only the influence of GLU on HbA1c is often paid attention to, while the influence of Hb factors on HbA1c level is ignored. resulting in inaccurate measurements

Method used

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  • Detection system and detection method for correcting the influence of anemia on glycosylated hemoglobin measurement
  • Detection system and detection method for correcting the influence of anemia on glycosylated hemoglobin measurement
  • Detection system and detection method for correcting the influence of anemia on glycosylated hemoglobin measurement

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Embodiment 1

[0036] A detection system for correcting the influence of anemia on the measured value of glycated hemoglobin, which consists of a glycated hemoglobin analyzer and a detection kit, the detection kit includes R1-A reagent, R1-B reagent, R2 reagent and a chromatography card;

[0037] R1-A reagent:

[0038]

[0039] R of the above-mentioned borate derivative is a biphenyl ring structure containing a sulfonic acid group and an amino group, and the number of carbon atoms is 12;

[0040] After fully dissolving the R1-A reagent, 200 μL each was dispensed into round-bottomed brown centrifuge tubes, placed in a vacuum drying oven preheated at 45°C in advance, dried for 2 hours, removed from the cap, marked well, and stored at room temperature ,spare;

[0041] R1-B reagent:

[0042]

[0043] Dilute the volume to 1L with purified water;

[0044] After the preparation of the R1-B reagent is completed, dispense 5mL / bottle into the pre-prepared reagent bottle, make a mark, and stor...

Embodiment 2

[0054] A detection system for correcting the influence of anemia on the measured value of glycated hemoglobin, which consists of a glycated hemoglobin analyzer and a detection kit, the detection kit includes R1-A reagent, R1-B reagent, R2 reagent and a chromatography card;

[0055] R1-A reagent:

[0056]

[0057] The R group of the above-mentioned borate derivative is a biphenyl ring structure containing a sulfonic acid group and an amino group, and the number of carbon atoms is 18;

[0058] After the R1-A reagent is fully dissolved, 200μL each is dispensed into round-bottomed brown centrifuge tubes, placed in a vacuum drying oven preheated at 45°C, dried for 2 hours, removed from the cap, marked well, and stored at room temperature. spare;

[0059] R1-B reagent:

[0060]

[0061]

[0062] Dilute the volume to 1L with purified water;

[0063] After the preparation of the R1-B reagent is completed, dispense 5mL / bottle into the pre-prepared reagent bottle, make a mar...

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Abstract

The invention belongs to the technical field of medical devices, and in particular relates to a detection system and a detection method capable of correcting the influence of anemia on the measured value of glycated hemoglobin. The detection system mainly includes a glycated hemoglobin detection kit and a glycated hemoglobin analyzer, and the detection kit includes R1- A reagent, R1-B reagent, R2 reagent and chromatography card, R1-A reagent is dry powder; when using this detection system for detection, the glycated hemoglobin analyzer uses the reflection principle to read the color signal and automatically calculates the value of HbA1c, When an anemia sample is detected, the analyzer can give an alarm prompt "hemoglobin is too low" to inform that the sample test is abnormal. Adjust and increase the sample volume accordingly, and the HbA1c value of the anemia sample can be corrected to make it consistent with fasting. The blood glucose measurement value is more relevant and has more clinical guiding significance; and the detection method is simple and time-consuming.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a detection system and a detection method capable of correcting the influence of anemia on the measured value of glycosylated hemoglobin. Background technique [0002] Diabetes is an endocrine and metabolic disease with an incidence second only to cardiovascular diseases and tumors. Its etiology and pathogenesis have not yet been fully elucidated. In recent years, the incidence of diabetes has been on the rise, and it is a worldwide public health problem that seriously threatens human health. The traditional methods of diabetes diagnosis and treatment monitoring use fasting blood glucose, postprandial blood glucose and oral glucose tolerance test, but blood glucose parameters only represent the instantaneous blood glucose level when blood is drawn, and the measurement is inaccurate. In recent years, the detection of glycated hemoglobin (HbA1c) has received in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/25G01N21/55G01N21/01
CPCG01N21/25G01N21/55G01N21/01
Inventor 杨帆黎村艳薛庆建宋金玲顾晓云贾培艳梁鹏飞崔欣
Owner QINGDAO HIGHTOP BIOTECH
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