Methods for improving frailty and aging

A technique for frailty, aging, applied in the field of compositions for treating age-related diseases and/or improving frailty

Pending Publication Date: 2021-01-08
GENOME PROTECTION INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, both require long-term application

Method used

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  • Methods for improving frailty and aging
  • Methods for improving frailty and aging
  • Methods for improving frailty and aging

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0175] Example 1: Pharmacological stimulation of TLR5 improves quality of life and reduces frailty

[0176] This example describes a pharmacological flagellin-based agent and its use in preventing aging-related frailty and prolonging healthy lifespan ("healthspan") and longevity ("lifespan").

[0177] Preclinical models of aging. A generalized decline in most physiological functions, reduced regenerative capacity, impaired wound healing, progressively increased risk of various diseases or conditions, and increased systemic sterile inflammation occur throughout life in all mammals, leading to the accumulation of what is defined as debilitating Combination of symptoms. The increase in frailty observed in healthy animals and humans that is not caused or accelerated by any particular pathology is called chronological aging. The severity of the condition increases over time and reaches critical proportions as the organism approaches the age of its natural genetically determined ...

Embodiment 2

[0184] Example 2: Administration of Entomod to improve frailty index.

[0185] To assess the effect of Entomod treatment on the lifespan (Lifespan) and overall health (Healthspan) of animals, male and female NIH Swiss mice of different ages were given 5 daily injections of Entomod (5 μg / mouse, SQ ): "Old" (112 weeks old), "Middle-aged" (55 weeks old) and "Youth" (18 weeks old). The "youth" treatment group received a second round of treatment at 84 weeks. The control group consisted of sex- and age-matched mice given SQ injections with PBS instead of entomod. The experimental design is in Figure 8 shown in . During the experiments, mice were housed under standard conditions and monitored for mortality and morbidity. Survival was recorded as an indicator of lifespan. In addition, at various times after treatment (see Figure 8 ), a test was performed to determine PFI as a quantitative indicator of healthy lifespan.

[0186] Treated mice were allowed to age naturally unde...

Embodiment 3

[0190] Example 3: Administering Entomod to Patients to Improve Frailty Index.

[0191]A 66-year-old male patient was identified as having a recent history of decreased frailty index as determined using the frailty index (FI), physiological frailty index (PFI), Fried frailty score, Rockwood frailty index, frailty scale, or modified frailty index. Patients are administered a single cycle consisting of once-daily doses of entomod on every three consecutive days. Following administration of entomod, patients were monitored for frailty index using the frailty index (FI), physiological frailty index (PFI), Fried frailty score, Rockwood frailty index, frailty scale, or modified frailty index. After the administration of entomod, the decline in the patient's frailty index was reduced or the frailty index was improved.

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Abstract

In various aspects and embodiments provided are methods for treating age-related diseases or disorders and / or treating or preventing frailty in a patient. In certain embodiments the methods include administering a recombinant TLR5 agonist (e.g., a flagellin-based agent).

Description

technical field [0001] The present disclosure relates to compositions and methods for treating age-related diseases and / or ameliorating frailty. [0002] Cross References to Related Applications [0003] This application claims the benefit of U.S. Provisional Application No. 62 / 662,028, filed April 24, 2018, which is hereby incorporated by reference in its entirety. [0004] Instructions for text files submitted electronically [0005] The contents of the electronically filed text file are hereby incorporated by reference in their entirety: Copy of Sequence Listing in Computer Readable Format (File Name: "GPI-002PC_ST25.txt"; Date Created: April 24, 2019 ; file size: 59.9KB). Background technique [0006] Aging in mammals is associated with accumulation of somatic DNA damage, increased chronic systemic inflammation, and reduced efficiency of the immune system in clearing damaged cells. [0007] TLR5 agonists derived from flagellin have been developed as therapies for var...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61K38/17A61K39/02A61K39/09A61P1/00A61P19/00
CPCA61P19/00A61P1/00A61K38/164A61P39/00
Inventor 奥尔加·切尔诺瓦
Owner GENOME PROTECTION INC
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