Gliquidone and rosiglitazone composition and preparation method thereof
A technology of gliquizone and rosiglitazone, which is applied in the field of the composition of gliquizone and rosiglitazone and the preparation field thereof, can solve the problems of high dosage, poor effect and the like, and avoid the dosage of dosage. overly effective
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Embodiment 1
[0020] A composition of gliquidone and rosiglitazone, distributed according to the following weight components:
[0021] Gliquidone 30mg, rosiglitazone 1mg, sodium starch glycolate 10mg, hydroxypropyl cellulose 20mg, lactose 40mg, magnesium stearate 1mg.
Embodiment 2
[0023] A preparation method of a composition of gliquidone and rosiglitazone, comprising the following steps:
[0024] First batching, weighing raw materials and auxiliary materials according to the amount of components;
[0025] Gliquidone 80mg, rosiglitazone 3mg, sodium starch glycolate 15mg, hydroxypropyl cellulose 30mg, lactose 100mg, magnesium stearate 3mg.
[0026] Further, soak the hydroxypropyl cellulose in water for 2-5 hours, and keep the temperature of the water in the water at 50-70°C;
[0027] Further, preheat sodium carboxymethyl starch and lactose to 40-60°C, and then mix them evenly with hydroxypropyl cellulose soaked in water to obtain premixed auxiliary materials, and keep the mixing temperature at 50-70°C;
[0028] Further, grind the premixed auxiliary materials with a colloid mill;
[0029] Further, the ground premixed auxiliary material is spray-dried to obtain a dry premixed auxiliary material after drying;
[0030] Further, pass the gliquidone, rosigl...
Embodiment 3
[0033] A composition of gliquidone and rosiglitazone, with the following weight ratio components:
[0034] Gliquidone 100mg, rosiglitazone 4mg, sodium starch glycolate 20mg, hydroxypropyl cellulose 35mg, lactose 140mg, magnesium stearate 5mg.
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