Gliquidone and rosiglitazone composition and preparation method thereof
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A technology of gliquizone and rosiglitazone, which is applied in the field of the composition of gliquizone and rosiglitazone and the preparation field thereof, can solve the problems of high dosage, poor effect and the like, and avoid the dosage of dosage. overly effective
Pending Publication Date: 2021-01-22
CHENGDU HENGRUI PHARMA
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[0005] At present, drug therapy is mainly used in China, and individualized treatment is required. Therefore, when the effect of single drug is not good, and other hypoglycemic drugs cannot achieve the goal of blood sugar control, in order to avoid excessive dosage of single drug, a new diabetes mellitus is proposed. It is necessary to provide patients with more choices for therapeutic pharmaceutical compositions
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Embodiment 1
[0020] A composition of gliquidone and rosiglitazone, distributed according to the following weight components:
[0026] Further, soak the hydroxypropyl cellulose in water for 2-5 hours, and keep the temperature of the water in the water at 50-70°C;
[0027] Further, preheat sodium carboxymethyl starch and lactose to 40-60°C, and then mix them evenly with hydroxypropyl cellulose soaked in water to obtain premixed auxiliary materials, and keep the mixing temperature at 50-70°C;
[0028] Further, grind the premixed auxiliary materials with a colloid mill;
[0029] Further, the ground premixed auxiliary material is spray-dried to obtain a dry premixed auxiliary material after drying;
[0030] Further, pass the gliquidone, rosigl...
Embodiment 3
[0033] A composition of gliquidone and rosiglitazone, with the following weight ratio components:
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Abstract
The present invention belongs to the field of medicine processing and discloses a gliquidone and rosiglitazone composition and a preparation method thereof. The gliquidone and rosiglitazone composition is composed of the following raw medicines in parts by weight: 30 mg-180 mg of gliquidone, 1 mg-8 mg of rosiglitazone, 10 mg-30 mg of carboxymethyl starch, 20 mg-50 mg of hydroxypropyl cellulose, 40mg-240 mg of lactose, and 1 mg-10 mg of magnesium stearate. The gliquidone and rosiglitazone are combined together, an adhesive, a diluent, a disintegrating agent and a lubricant are added as auxiliary materials, a part of the auxiliary materials are premixed, and finally dry tabletting or direct filling of capsules is carried out. Aiming at facts that diabetes is mainly treated by medicines currently domestically and individualized treatment is required, in order to avoid over-high dosage of a single medicine when a medicine effect of the single medicine is poor, the novel diabetes treatmentmedicine composition is provided to provide more choices for patients.
Description
technical field [0001] The invention relates to the field of pharmaceutical processing, and relates to a composition of gliquidone and rosiglitazone and a preparation method thereof. Background technique [0002] Diabetes is the chronic disease with the largest number of patients in my country, and it is tending to be younger. Diabetes is a group of clinical syndromes caused by the interaction of genetic and environmental factors. Absolute or relative insufficiency of insulin secretion and decreased sensitivity of target tissue cells to insulin lead to a series of metabolic disorders such as sugar, protein, fat, water and electrolytes. Clinically, hyperglycemia is the main sign, and prolonged illness can cause damage to multiple systems. Acute metabolic disorders such as ketoacidosis can occur in severe illness or stress. [0003] Gliquidone is the second-generation oral sulfonylurea hypoglycemic drug, which is a highly active pro-islet β-cell agent. It binds to specific ...
Claims
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