Preparation method and application of oxytropis chiliophylla polysaccharide

A technology of edaxa polysaccharide and edaxa, which is applied in the field of plant polysaccharide preparation, can solve the problems of no obvious analgesic effect and disappearance of analgesic effect, and achieve convenient storage and transportation, improved stability and effectiveness, and accurate The effect of controlling the dosage

Active Publication Date: 2021-01-22
西藏甘露藏药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In addition, Tibetan medicinal materials are mostly prepared by processing methods. However, the existing technology shows that Erda Xia did not exert obvious analgesic effect after processing, indicating that its analgesic effect disappeared after processing. Therefore, modern methods are used to process Tibetan medicine Erda Summer is necessary to achieve the purpose of not impairing its efficacy

Method used

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  • Preparation method and application of oxytropis chiliophylla polysaccharide
  • Preparation method and application of oxytropis chiliophylla polysaccharide
  • Preparation method and application of oxytropis chiliophylla polysaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Embodiment 1: A kind of dry ointment of Erdaxia:

[0094] The present embodiment provides a kind of dry ointment of Erda Xia, such as figure 1 and figure 2 As shown, the dry ointment of Erdaxia is prepared through the following steps:

[0095] Step 1. After pretreatment of 2.5kg of Erdaxia herbs, add 25L of water to a 500L sandwich pot for the first decoction. The decoction temperature is 190°C, and the decoction time is 80-100min, stirring every 20min. once. After decocting, filter for the first time (100 mesh sieve) to obtain medicine dregs I and medicine liquid I.

[0096] Step 2. Add 25L of water to the medicinal residue I, and decoct for the second time. The decoction temperature is 190°C, the decoction time is 50-70min, and stirring once every 20min; after decoction, perform the second filtration (100 mesh sieve) , to obtain dregs II and liquid II.

[0097] Step 3, mixing the medicinal liquid I and the medicinal liquid II together to obtain a filtered medic...

Embodiment 2

[0116] Embodiment 2: Odaxia polysaccharide:

[0117] This embodiment provides a kind of Odaxia polysaccharide, and the Odaxia polysaccharide is prepared by the following steps:

[0118] Step 1. Edaxia is dried to a water content of 16%, pretreated by twin-screw extruder extrusion and puffing under the conditions of feeding speed 10kg / h, screw speed 500r / min, extrusion temperature 115°C, and pulverized until over 100 mesh sieve;

[0119] Step 2. After pre-treating 2kg of the Erdaxia medicinal material powder obtained in Step 1, add 20L of water to a 500L-capacity sandwich pot for the first decoction. The decoction temperature is 190°C and the decoction time is 100min. Stir for 20 minutes at 120r / min, filter through a 100-mesh sieve to obtain medicinal residue I and medicinal liquid I; add the medicinal residue I to 20L water for the second decoction, decoction temperature 190°C, decoction time 60min, every 20min Stirring at 120r / min for 2min, filtering through a 100-mesh siev...

Embodiment 3

[0128] Example 3: another urdaxia polysaccharide:

[0129] This embodiment provides another kind of Odaxia polysaccharide, which includes small molecule Odaxia polysaccharide a and small molecule Odaxia polysaccharide b, and its preparation method specifically includes:

[0130] Step 1. Edaxia is dried to a water content of 10%, pretreated with a twin-screw extruder at a feed rate of 10kg / h, a screw speed of 500r / min, and an extrusion temperature of 115°C. 100 mesh sieve;

[0131] Step 2 to step 8 are all the same as in Example 2.

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Abstract

The invention relates to the technical field of plant polysaccharide preparation, in particular to a preparation method and application of oxytropis chiliophylla polysaccharide. The preparation methodcomprises the following steps: extruding oxytropis chiliophylla powder, then carrying out decocting and filtering to obtain a filtered liquid medicine, performing stirring and concentration to obtainan extract, performing decocting and concentration to obtain a dry paste semi-finished product, carrying out drying to obtain dry paste, and carrying out alcohol precipitation, water extraction, thermal acidolysis and alcohol precipitation to obtain the oxytropis chiliophylla polysaccharide. The dry paste is prepared after the oxytropis chiliophylla medicinal material is subjected to extrusion pretreatment by a twin-screw extruder, then the oxytropis chiliophyllapolysaccharide is prepared, the yield and activity of the oxytropis chiliophylla polysaccharide can be remarkably improved, organicacid is applied to hydrolyze macromolecular polysaccharide to obtain high-activity micromolecular polysaccharide, the prepared ooxytropis chiliophylla dry paste and polysaccharide both have excellentanalgesic effects, and the oxytropis chiliophylla polysaccharide obtained by compounding with the technical scheme can delay senescence.

Description

technical field [0001] The invention relates to the technical field of plant polysaccharide preparation, in particular to a preparation method and application of urdaxia polysaccharide. Background technique [0002] Odasha ( OxytropischiliophyllaRoyle ex Benth ), alias Oxytropis verticillum, Oxytropis stinky, Quda Mao, Dejiba, Duizibaduo, etc., belong to the genus Oxytropis of Fabaceae Papilionaceae, and grow in river beaches, sandy land, and valleys at an altitude of 2700-4300m , hillsides, shrub forests, and meadows, distributed in Qinghai, Tibet, Gansu, Sichuan and other places. Known as the king of herbal medicine in Tibetan medicine, it is mainly used for curing sores, facilitating bowel movements, detoxification, clearing swelling, and stopping bleeding. It can treat various diseases such as anthrax, leprosy, influenza, and tonsillitis. Herbs of choice. There are many records of Er Daxia in the classics of Tibetan medicine. For example, "Tibetan Medicine Chronicles...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K36/48A61P29/00A61P37/04A61P39/06C08B37/00
CPCA61K31/715A61K36/48A61K2236/15A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P29/00A61P37/04A61P39/06C08B37/0003
Inventor 达卓玛旦增洛布平措南加尼玛拉宗格桑坚赞
Owner 西藏甘露藏药股份有限公司
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