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Reagent for preventing or treating CyHV-2 infection of fishes and application

一种cyhv-2、试剂的技术，应用在应用、抗病毒剂、气候变化适应等方向，能够解决没有行之有效的方案等问题，达到增强免疫抗性、提高存活率的效果

Active Publication Date: 2021-01-29
GONGLIN IND SHENZHEN +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there have been studies and reports on the molecular detection methods of CyHV-2, but there is no effective plan for how to prevent or treat related diseases caused by CyHV-2 infection

Method used

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  • Reagent for preventing or treating CyHV-2 infection of fishes and application
  • Reagent for preventing or treating CyHV-2 infection of fishes and application
  • Reagent for preventing or treating CyHV-2 infection of fishes and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0033] 1. Establishment of fulminant hemorrhagic virus challenge model in crucian carp

[0034] 1. Virus isolation

[0035] (1) Virus sampling and experimental animals

[0036] Carp spring viremia virus (abbreviated as SVCV) and koi herpes virus (abbreviated as KHV) were provided and preserved by the Animal and Plant Inspection and Quarantine Technology Center of Shenzhen Entry-Exit Inspection and Quarantine Bureau. The diseased crucian carp was collected from an allogenic silver crucian carp farm in Yancheng, with a body length of about 24 ± 1 cm and an average weight of 250 ± 10 g. Koi fin cell line (KF for short) was provided by the Animal and Plant Inspection and Quarantine Technology Center of Shenzhen Entry-Exit Inspection and Quarantine Bureau. A large amount of blood naturally overflowed from the lower edge of the gill cover, the body surface was congested and the abdomen was swollen, the base of the eye socket was congested, and the gill filaments were severely blee...

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PUM

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Abstract

The invention discloses a reagent for preventing or treating CyHV-2 infection of fishes and application. The reagent for preventing or treating CyHV-2 infection of fishes comprises a fifth polypeptide, and the fifth polypeptide is a sequence shown as Seq ID No.5. According to the reagent for preventing or treating CyHV2 infection of fishes, the fifth polypeptide can be specifically combined with CyHV-2 in an immune mode, and the immune resistance of fish bodies to CyHV-2 infection diseases can be specifically enhanced in a feeding or soaking mode or other modes, so that the survival rate of fish schools infected with CyHV-2 is increased, and a new scheme and way are provided for prevention and treatment of CyHV-2 infection.

Description

technical field [0001] The present application relates to the field of prevention and treatment of carp herpesvirus type II infection, in particular to a reagent and application for preventing or treating CyHV-2 infection in fish. Background technique [0002] CyHV-2 is the abbreviation of carp herpes virus type II, also known as goldfish hematopoietic necrosis virus (GFHNV), which is a disease of goldfish hematopoietic necrosis (goldfishhaematopoietic necrosis, abbreviated GFHN), crucian carp fulminant hemorrhagic disease and other diseases. the pathogen. [0003] CyHV-2 has high infectivity, but the infection spectrum of CyHV-2 is small, only infecting goldfish, crucian carp and their common variants, such as Hedrick et al. (2006) found that the hybrid of goldfish and carp can also infect CyHV-2 become carriers of the virus. Eggs, fry, fingerlings and broodstock can all be infected, but juveniles are more susceptible than adults, and juveniles less than 1 year old are us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/00G01N33/569A61K38/16A61P31/22A23K20/147A23K50/80
CPCA61P31/22A23K20/147A23K50/80G01N33/56994A61K38/16Y02A40/81
Inventor 刘莹刘荭贾鹏温智清黄志坚简廷涵王寒
Owner GONGLIN IND SHENZHEN
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