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A kind of reagent and application for preventing or treating fish infected with cyhv-2

A technology of cyhv-2 and reagents, applied in the fields of application, fish farming, antiviral agents, etc., can solve problems such as no effective solutions, and achieve the effects of enhancing immune resistance, high survival rate, and improving survival rate

Active Publication Date: 2020-11-24
GONGLIN IND SHENZHEN +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there have been studies and reports on the molecular detection methods of CyHV-2, but there is no effective plan for how to prevent or treat related diseases caused by CyHV-2 infection

Method used

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  • A kind of reagent and application for preventing or treating fish infected with cyhv-2
  • A kind of reagent and application for preventing or treating fish infected with cyhv-2
  • A kind of reagent and application for preventing or treating fish infected with cyhv-2

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0040] 1. Establishment of the challenge model of crucian carp fulminant hemorrhagic disease

[0041] 1. Virus Isolation

[0042] (1) Virus sampling and experimental animals

[0043] Carp spring viremia virus (abbreviated SVCV) and koi herpes virus (abbreviated KHV) were provided and preserved by the Animal and Plant Inspection and Quarantine Technology Center of Shenzhen Entry-Exit Inspection and Quarantine Bureau. The diseased crucian carp was collected from a heterogeneous gibel carp farm in Yancheng, with a body length of about 24±1cm and an average weight of 250±10g. Koi fin cell line (KF for short) was provided by the Animal and Plant Inspection and Quarantine Technology Center of Shenzhen Entry-Exit Inspection and Quarantine Bureau. When the dying fish on the lower tuyere of the slow planktonic fish pond were salvaged, a large amount of blood naturally overflowed from the lower edge of the gill cover, the body surface was congested and the abdomen was swollen, the bas...

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Abstract

The application discloses a reagent and application for preventing or treating CyHV‑2 infection in fish. The reagent used in the present application for preventing or treating fish infection with CyHV-2 includes at least one of the first polypeptide to the eighth polypeptide; the first polypeptide to the eighth polypeptide are Seq ID No.1 to 8 in sequence sequence shown. The reagent used for preventing or treating CyHV-2 infection in fish according to the present application, the first polypeptide to the eighth polypeptide can specifically immunologically bind CyHV-2, and can specifically enhance fish by feeding or soaking. The immune resistance of CyHV‑2 infected diseases can be improved, thereby improving the survival rate of fish schools infected with CyHV‑2, and providing a new scheme and approach for the prevention and treatment of CyHV‑2 infection.

Description

technical field [0001] The application relates to the field of prevention and treatment of carp herpesvirus type II infection, in particular to a reagent for preventing or treating CyHV-2 infection in fish and its application. Background technique [0002] CyHV-2 is the abbreviation of carp herpesvirus type Ⅱ, also known as goldfish haematopoietic necrosis virus (GFHNV for short), which is a disease of goldfish hematopoietic necrosis (goldfishhaematopoietic necrosis, abbreviated GFHN), crucian carp fulminant hemorrhagic disease and other diseases. pathogen. [0003] CyHV-2 has high infectivity, but the infection spectrum of CyHV-2 is small, and only infects goldfish, crucian carp and their common variants. For example, Hedrick et al. (2006) found that hybrids of goldfish and carp can also infect CyHV-2 become carriers of the virus. Fish eggs, fry, fingerlings, and broodstock can all be infected, but juveniles are more susceptible than adults, and it is usually juveniles th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/16A61P31/22A23K20/147A23K50/80A01K61/13C12Q1/70C12Q1/686G01N33/533G01N33/543G01N33/561G01N33/569G01N33/577G01N33/68
CPCA61P31/22A23K20/147A23K50/80G01N33/56994A61K38/16Y02A40/81
Inventor 温智清刘莹贾鹏刘荭黄志坚简廷涵王寒
Owner GONGLIN IND SHENZHEN
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