Medical delivery devices with inhibited oxygen permeation
A kind of equipment and medical technology, applied in the direction of medical preparations containing active ingredients, other medical devices, drug delivery, etc., can solve the problems of increasing the complexity of the overall structure of devices or pharmaceutical preparations
Active Publication Date: 2021-02-02
WL GORE & ASSOC INC
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- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
However, these methods add complexity to the overall construction of the device or drug formulation
Method used
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[0027] Those skilled in the art will readily appreciate that various aspects of the present disclosure may be implemented by any number of methods and devices configured to perform the intended functions. It should also be noted that the drawings referred to herein are not necessarily drawn to scale, but may be exaggerated to illustrate aspects of the disclosure, and in this regard, the drawings should not be considered limiting. The terms "silicone" and "silicone oil" are used interchangeably herein.
[0028] The present disclosure relates to silicone-free or substantially silicone-free medical delivery devices (eg, syringes, auto-injectors, and pens) for storing and delivering medical fluids. As used herein, the term "substantially free" means that the barrel and / or stopper of the syringe have no quantifiable or trace amounts of silicone or other liquid lubricants. The medical delivery device is configured to inhibit or prevent the penetration of oxygen into the barrel of t...
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Abstract
The present disclosure relates to medical devices such as syringes, auto- injectors, and pens that inhibit oxygen permeation into the fluid chamber. The medical device includes a lubricant-free (e.g.,silicone) or a siliconized barrel having an interior surface defining a fluid chamber, an elastomeric stopper, and a plunger rod. In one embodiment, at least a portion of the interior surface of thebarrel is reduced to increase the interference fit between the stopper and the barrel. In another embodiment, the stopper may include a plurality of ribs and a valley between each pair of ribs may include a ring member provided in each of the valleys. The ring member includes an oxygen-absorbing, an oxygen-adsorbing material, or both, to bind any oxygen that permeates into the syringe, auto-injector, or pen. In yet another embodiment, the stopper may include a barrier coating including an oxygen barrier material to inhibit or prevent oxygen permeation.
Description
technical field [0001] The present disclosure relates to medical delivery devices, and in particular to syringes, auto-injectors, and pens configured to inhibit the penetration of oxygen into fluids or substances contained within the medical delivery device. Background technique [0002] Medical delivery devices such as syringes, automatic injectors and pens typically include a barrel, a stop positioned within the barrel, and a plunger rod or actuation mechanism to displace the stop. As the pharmaceutical industry seeks new and more convenient methods of drug delivery, prefilled syringes, auto-injectors and pens have become the preferred choice for unit dose drug delivery. Prefilled syringes minimize drug waste and extend product life while enabling patients to self-administer injectable medications. Specifically, prefilled syringes, autoinjectors, and pens eliminate dosing errors and prevent overfilling. Drug instability over extended periods of time is a continuing probl...
Claims
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IPC IPC(8): A61M5/315A61M5/31
CPCA61M5/315A61M5/31505A61M5/31513A61M2205/0222A61M2205/0238A61M5/3129A61M2005/3131A61M5/3135A61M2005/3151A61M5/28A61M2005/3117A61M2205/0216A61K9/0019A61K38/4846A61M5/20A61M2210/0612
Inventor E·H·库里E·C·贡策尔C·M·斯克笛
Owner WL GORE & ASSOC INC