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Traditional Chinese medicine extract composition, melanoma inhibiting drug, preparation method and application

An extract and composition technology, applied in the field of traditional Chinese medicine extract composition, can solve the problems of short overall survival period, inaccurate curative effect, high drug toxicity, etc. Effect

Active Publication Date: 2021-02-09
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] As mentioned above, the current treatment methods for melanoma have problems such as inaccurate curative effect, low effective rate, short overall survival period, high drug toxicity, and high price, and conventional pro-apoptotic treatment methods and methods are not effective for melanoma cells. Sensitive, therefore, the present invention provides a kind of traditional Chinese medicine extract composition, the medicine that suppresses melanoma and preparation method and application

Method used

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  • Traditional Chinese medicine extract composition, melanoma inhibiting drug, preparation method and application
  • Traditional Chinese medicine extract composition, melanoma inhibiting drug, preparation method and application
  • Traditional Chinese medicine extract composition, melanoma inhibiting drug, preparation method and application

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Embodiment 1

[0029] The embodiment of the present invention provides a traditional Chinese medicine extract composition, which is composed of the alcohol extract of Ligustrum lucidum and the alcohol extract of Eclipta chinensis at a crude drug ratio of 1:1. The preparation method of the alcoholic extract of Ligustrum lucidum is: extracting Ligustrum lucidum with 10 times the amount of 80% v / v ethanol aqueous solution twice, each time for 2 hours, combining the extracts, concentrating to a concentrated solution, and then drying in vacuum at 50°C to obtain Ligustrum lucidum extract, that is, the alcoholic extract of Ligustrum lucidum. The preparation method of Eclipta alcoholic extract is as follows: extract Eclipta 10 times with 75% v / v ethanol aqueous solution twice, each time for 2 hours, combine the extracts, concentrate to a concentrated solution, and then dry in vacuum at 50°C to obtain ink Eclipta extract, Jimo Eclipta ethanol extract.

Embodiment 2

[0031] The embodiment of the present invention provides a traditional Chinese medicine extract composition, which is composed of the alcohol extract of Ligustrum lucidum and the alcohol extract of Eclipta chinensis at a crude drug ratio of 0.8:1. The preparation method of the alcoholic extract of Ligustrum lucidum is: extracting Ligustrum lucidum with 10 times the amount of 80% v / v ethanol aqueous solution twice, each time for 2 hours, combining the extracts, concentrating to a concentrated solution, and then drying in vacuum at 50°C to obtain Ligustrum lucidum extract, that is, the alcoholic extract of Ligustrum lucidum. The preparation method of Eclipta alcoholic extract is as follows: extract Eclipta 10 times with 75% v / v ethanol aqueous solution twice, each time for 2 hours, combine the extracts, concentrate to a concentrated solution, and then dry in vacuum at 50°C to obtain ink Eclipta extract, Jimo Eclipta ethanol extract.

Embodiment 3

[0033] The embodiment of the present invention provides a traditional Chinese medicine extract composition, which is composed of the alcohol extract of Ligustrum lucidum and the alcohol extract of Eclipta chinensis with a crude drug ratio of 1.2:1. The preparation method of the alcoholic extract of Ligustrum lucidum is: extracting Ligustrum lucidum with 10 times the amount of 80% v / v ethanol aqueous solution twice, each time for 2 hours, combining the extracts, concentrating to a concentrated solution, and then drying in vacuum at 50°C to obtain Ligustrum lucidum extract, that is, the alcoholic extract of Ligustrum lucidum. The preparation method of Eclipta alcoholic extract is as follows: extract Eclipta 10 times with 75% v / v ethanol aqueous solution twice, each time for 2 hours, combine the extracts, concentrate to a concentrated solution, and then dry in vacuum at 50°C to obtain ink Eclipta extract, Jimo Eclipta ethanol extract.

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Abstract

The invention belongs to the technical field of traditional Chinese medicine anticancer treatment and particularly relates to a traditional Chinese medicine extract composition, a melanoma inhibitingdrug, a preparation method and application. The traditional Chinese medicine extract composition comprises a ligustrum lucidum alcohol extract and a herba ecliptae alcohol extract which are in a crudedrug ratio of (0.5-1.5): 1. According to the traditional Chinese medicine extract composition, the action of inhibiting activity of melanoma cells is exerted through inhibiting cell cycle G2 / M-stagetime phase, cell proliferation and cell cloning, so that the apoptosis of the melanoma cells is promoted, a good experiment foundation is settled for traditional Chinese medicine treatment on tumors such as malignant melanoma, and a new view is developed. The traditional Chinese medicine extract composition can be used for preparing drugs for inhibiting melanoma and is applied to treatment or deepresearches on the melanoma.

Description

technical field [0001] The invention belongs to the technical field of anti-cancer of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine extract composition, a medicine for inhibiting melanoma, a preparation method and an application. Background technique [0002] Malignant melanoma (MM), referred to as malignant melanoma or melanoma for short, is a tumor derived from melanocytes that occurs mostly in the skin or mucous membrane. One of the most common lethal tumors of the skin. The treatment methods for advanced melanoma include surgical resection, radiation therapy, chemotherapy, immunosuppressive therapy and other comprehensive treatment methods, but the curative effect is not exact, and the overall five-year survival rate has not been significantly increased. Moreover, chemotherapeutic drugs (such as dacarbazine) have low objective effective rate, short overall survival period, high toxicity of IL-2 drugs, low efficacy at low doses...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/638A61K36/28A61P35/00
CPCA61K36/638A61K36/28A61P35/00A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 陈敬高秀梅陈璐王虹张璐莎
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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