Composition with anti-inflammatory and analgesic effects, soluble microneedle patch and preparation method of soluble microneedle patch

An anti-inflammatory and analgesic composition technology, which is applied in the field of anti-inflammatory and analgesic compositions, can solve the problems of poor mechanical properties, slow dissolution speed of microneedles, inability of microneedles to penetrate the skin, etc., and achieve mechanical properties and puncture performance Good, improve the effect of rapid anti-inflammatory and analgesic, fast intradermal dissolution

Pending Publication Date: 2021-02-19
广州新济薇娜生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the drug delivery efficiency and drug action effect of soluble microneedles depend on their mechanical properties and dissolution rate in the skin; if the mechanical properties of the microneedles are poor, resulting in low strength and poor toughness of the microneedles, the microneedles cannot penetrate Penetrating the skin so that the active ingredient of the drug cannot be effectively delivered; if the dissolution rate of the microneedle in the skin is too slow, it cannot meet the requirement of rapid release of the drug, which will affect the absorption and utilization of the active ingredient

Method used

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  • Composition with anti-inflammatory and analgesic effects, soluble microneedle patch and preparation method of soluble microneedle patch
  • Composition with anti-inflammatory and analgesic effects, soluble microneedle patch and preparation method of soluble microneedle patch
  • Composition with anti-inflammatory and analgesic effects, soluble microneedle patch and preparation method of soluble microneedle patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] The dissolvable microneedle patch with anti-inflammatory and analgesic effects provided in this example is composed of a needle point and a base; the raw materials of the needle point are as follows (in parts by weight): 0.1 parts of capsaicin, 0.5 parts of methyl salicylate, 1 part of cannabis leaf extract, 1 part of paeonol, 2 parts of PEG-4002, 13 parts of ethanol, 5 parts of dextran 40, 3 parts of mannose, 6 parts of polyvinylpyrrolidone (molecular weight is 30kDa), sodium hyaluronate ( The molecular weight is 8000Da) 15 parts; the raw material composition of the substrate is as follows: 0.4 parts of glycerin, 20 parts of hydroxypropyl cellulose.

[0072] The preparation method of the soluble microneedle patch with anti-inflammatory and analgesic effects provided in this example is as follows:

[0073] S1: Preparation of needle tips: After mixing the above-mentioned raw materials for needle tip preparation, add 53.12 parts of distilled water and stir to dissolve to ...

Embodiment 2

[0077] The difference between this example and Example 1 is that the solubilizer is Tween 60. details as follows:

[0078] The dissolvable microneedle patch with anti-inflammatory and analgesic effects provided in this example is composed of a needle point and a base; the raw materials of the needle point are as follows (in parts by weight): 0.1 parts of capsaicin, 0.5 parts of methyl salicylate, 1 part of cannabis leaf extract, 1 part of paeonol, 2 parts of Tween 60, 13 parts of ethanol, 5 parts of dextran 40, 3 parts of mannose, 6 parts of polyvinylpyrrolidone (molecular weight: 30kDa), sodium hyaluronate (Molecular weight is 8000Da) 15 parts; The raw material composition of substrate is as follows: 0.4 parts of glycerin, 20 parts of hydroxypropyl cellulose.

[0079] The preparation method of the soluble microneedle patch with anti-inflammatory and analgesic effects provided in this example is as follows:

[0080] S1: Preparation of needle tips: After mixing the above-ment...

Embodiment 3

[0083] The difference between this example and Example 1 is that the molecular weight of sodium hyaluronate in the microneedle framework material is different. details as follows:

[0084] The dissolvable microneedle patch with anti-inflammatory and analgesic effects provided in this example is composed of a needle point and a base; the raw materials of the needle point are as follows (in parts by weight): 0.1 parts of capsaicin, 0.5 parts of methyl salicylate, 1 part of cannabis leaf extract, 1 part of paeonol, 2 parts of PEG-4002, 13 parts of ethanol, 5 parts of dextran 40, 3 parts of mannose, 6 parts of polyvinylpyrrolidone (molecular weight is 30kDa), sodium hyaluronate ( The molecular weight is 60000Da) 15 parts; the raw material composition of the substrate is as follows: 0.4 parts of glycerin, 20 parts of hydroxypropyl cellulose.

[0085] The preparation method of the soluble microneedle patch with anti-inflammatory and analgesic effects provided in this example is as ...

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Abstract

The invention relates to a composition with anti-inflammatory and analgesic effects, a soluble microneedle patch and a preparation method of the soluble microneedle patch. The composition with the anti-inflammatory and analgesic effects comprises the following components in parts by weight: 0.5-2 parts of capsaicin, 3-10 parts of methyl salicylate, 5-20 parts of a cannabis sativa leaf extract, and5-20 parts of paeonol. The soluble microneedle patch consists of a needle tip, and a substrate; the needle tip is prepared from the composition with the anti-inflammatory and analgesic effects, a solubiliser, and a microneedle framework material; and the composition with the anti-inflammatory and analgesic effects, the solubiliser and the microneedle framework material are proportioned in a massratio of 1 to 0.1-2 to 8-20. The soluble microneedle patch has good mechanical properties and a relatively high intradermal dissolution rate; and moreover the soluble microneedle patch has good anti-inflammatory and analgesic effects.

Description

[0001] field of invention [0002] The invention belongs to the field of microneedles, and in particular relates to a composition with anti-inflammatory and analgesic effects, a soluble microneedle patch and a preparation method thereof. Background technique [0003] Capsaicin and methyl salicylate are commonly used drugs for anti-inflammatory and analgesic, and the current common dosage forms are gel or cataplasm. Capsaicin and methyl salicylate are highly irritating to the skin and mucous membranes. They are administered in the form of gels or cataplasms. Due to the low delivery efficiency of active substances, larger doses are often required. [0004] Soluble microneedles are a new type of transdermal delivery method, which uses micron-sized needles to penetrate the skin, and then the needles that penetrate the skin absorb body fluids and dissolve in the body, and the drug directly breaks through the skin barrier and enters the body to play a role. Compared with the tradit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61K9/70A61K9/00A61K47/10A61K47/36A61K47/26A61K47/32A61P29/00A61M37/00A61K31/165A61K31/618A61K31/12
CPCA61K9/0021A61K9/7023A61K31/12A61K31/165A61K31/618A61K36/60A61K47/10A61K47/26A61K47/32A61K47/36A61M37/0015A61M2037/0046A61M2037/0053A61P29/00A61K2300/00
Inventor 温新国张敏敏陈叶盛陈航平冯家颖任春艳
Owner 广州新济薇娜生物科技有限公司
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