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Oral liquid containing cinnamon, processed aconite root and prepared rehmannia root

A technology of Rehmannia glutinosa oral liquid and Guifu, which is applied in the fields of blood diseases, dispersion liquid transportation, extracellular fluid diseases, etc., can solve the problems of low extraction rate of active ingredients, inability to fully retain medicinal materials, and large dosage of drugs, so as to improve biological efficiency. Availability, removal of bitterness and unpleasant odor, effect of low dosage

Pending Publication Date: 2021-02-26
江西诚志永丰药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A variety of preparation methods for Guifu Rehmannia preparations have been disclosed in the prior art, but there are often defects in the extraction rate of active ingredients being low, the active ingredients of the medicinal materials cannot be fully retained to ensure the curative effect, the dosage of the medicine is large, and the taste is bitter and astringent , cannot meet the rapid development of medical science and technology

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A kind of Guifu Dihuang oral liquid, its preparation process comprises the following steps:

[0028] S1. Rehmannia glutinosa, wine cornel, and tree peony bark were pulverized into 60 meshes respectively to obtain rehmannia glutinosa powder, wine cornus powder, and tree peony bark powder; mixed rehmannia glutinosa powder, wine cornus powder, and tree peony bark powder with water, sucrose, Mix the mixture of rice bran evenly, sterilize at 115°C for 30 minutes, cool to 30°C, inoculate the starter, and ferment under airtight conditions; wherein, the fermentation temperature is 30°C, the fermentation time is 50 hours, and after the fermentation is completed, it is dried to obtain Fermented Rehmannia glutinosa, fermented wine cornus and fermented tree peony bark;

[0029] S2. Mix cinnamon and fermented Moutan Cortex and then pulverize them, and then place them in a supercritical carbon dioxide extraction device for supercritical carbon dioxide extraction to obtain volatile oi...

Embodiment 2

[0036] A kind of Guifu Dihuang oral liquid, its preparation process comprises the following steps:

[0037] S1. Rehmannia glutinosa, wine cornus, and tree peony bark were pulverized into 100 meshes respectively to obtain rehmannia glutinosa powder, wine cornus powder, and tree peony bark powder; mixed rehmannia glutinosa powder, wine cornus powder, and tree peony bark powder with water, sucrose, Mix the rice bran mixture evenly, sterilize at 110°C for 50 minutes, cool to 20°C, inoculate the starter, and ferment separately under airtight conditions; wherein, the fermentation temperature is 32°C, the fermentation time is 30 hours, and after the fermentation is completed, dry and separate Obtain fermented Rehmannia glutinosa, fermented wine cornus and fermented peony cortex; wherein, in the fermentation process, the weight ratio of rehmannia glutinosa powder, water, sucrose, rice bran, and starter is 8:70:3:8:7; wine cornus The weight ratio of powder, water, sucrose, rice bran, a...

Embodiment 3

[0045] A kind of Guifu Dihuang oral liquid, its preparation process comprises the following steps:

[0046] S1. Rehmannia glutinosa, wine cornus, and tree peony bark were pulverized into 100 meshes respectively to obtain rehmannia glutinosa powder, wine cornus powder, and tree peony bark powder; mixed rehmannia glutinosa powder, wine cornus powder, and tree peony bark powder with water, sucrose, Mix the mixture of rice bran evenly, sterilize at 113°C for 50 minutes, cool to 20°C, inoculate the starter, and ferment under airtight conditions; wherein, the fermentation temperature is 31°C, the fermentation time is 38 hours, and after the fermentation is completed, it is dried to obtain Fermented rehmannia glutinosa, fermented wine cornus and fermented peony bark; wherein, during the fermentation process, the weight ratio of rehmannia glutinosa powder, water, sucrose, rice bran, and starter is 15:50:7:4:5; wine cornus powder The weight ratio of water, sucrose, rice bran, and start...

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PUM

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Abstract

The invention discloses an oral liquid containing cinnamon, processed aconite root and prepared rehmannia root. A preparation method of the oral liquid comprises the following steps of: respectively uniformly mixing prepared rehmannia root powder, wine-prepared cornus powder and tree peony bark powder with a mixture of water, cane sugar and rice bran; sterilizing; cooling; inoculating a leaveningagent; fermenting and drying to obtain fermented prepared rehmannia root, fermented wine-prepared cornus and fermented tree peony bark; crushing cinnamon and fermented tree peony bark, and carrying out supercritical carbon dioxide extraction to obtain volatile oil and decoction dregs A; adding an ethanol solution into the fermented wine-prepared cornus, carrying out reflux extraction, and filtering to obtain filtrate A and decoction dregs B; crushing Chinese yam and poria cocos, adding water, and carrying out reflux extraction to obtain filtrate B and decoction dregs C; crushing processed aconite root, rhizoma alismatis, decoction dregs A, decoction dregs B, decoction dregs C and fermented prepared rehmannia root, adding ethanol for soaking, and sequentially carrying out ultrasonic and high-voltage pulsed electric field extraction to obtain filtrate C and decoction dregs D; adding water into the decoction dregs D, and decocting to obtain filtrate D; and mixing the filtrates with the volatile oil, concentrating, adding ethanol, standing, filtering, recovering ethanol, refrigerating, filtering, adding auxiliary materials, uniformly stirring, adding water, and uniformly stirring.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to Guifu Dihuang Oral Liquid. Background technique [0002] Guifu Dihuang preparations are representative medicines for treating common clinical symptoms such as deficiency of kidney yang, soreness and coldness of the waist and knees, limb edema, dysuria or excessive urination, phlegm retention, wheezing and coughing, and thirst. A variety of preparation methods for Guifu Rehmannia preparations have been disclosed in the prior art, but there are often defects in the extraction rate of active ingredients being low, the active ingredients of the medicinal materials cannot be fully retained to ensure the curative effect, the dosage of the medicine is large, and the taste is bitter and astringent , can not meet the rapid development of medical science and technology. Contents of the invention [0003] Based on the technical problems existing in the background te...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/08A61K47/46A61K47/12A61K47/26A61P29/00A61P13/12A61P7/10A61P13/00A61P11/10A61P11/06A61P11/14A61P43/00
CPCA61K9/0095A61K36/076A61K36/40A61K36/65A61K36/71A61K36/714A61K36/804A61K36/884A61K36/8945A61K47/12A61K47/26A61K47/46A61K2236/19A61K2236/37A61K2236/53A61P7/10A61P11/06A61P11/10A61P11/14A61P13/00A61P13/12A61P29/00A61P43/00A61K2300/00
Inventor 赵晓明陈志红蔡威
Owner 江西诚志永丰药业有限责任公司
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