Nanofiber-reinforced absorbable intraosseous fixation material and preparation method thereof

A nanofiber, fixing material technology, applied in fiber processing, medical science, electrospinning, etc., can solve problems such as threatening the life safety of patients, secondary injury to patients, obvious brittleness, etc., to shorten the healing time, improve the treatment effect, The effect of improving mechanical properties

Active Publication Date: 2021-03-09
STAR SPORTS MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] With the iterative update of medical technology, although traditional metals have high mechanical strength and fatigue resistance, which can meet the performance requirements of clinical operations, metal materials cannot be degraded in the body after they are implanted into the human body. Afterwards, a second operation is required to remove it, causing secondary injury to the patient.
In recent years, absorbable fixed grafts have received extensive attention due to their unique advantages, but there are also a series of problems, but compared with other non-absorbable materials, they also have certain limitations, such as poor crack resistance, low toughness, and brittleness. Obviously, the degradation rate is inconsistent with the bone ingrowth rate, etc., to a certain extent, it affects the appearance and service life of the absorbable fixation material, and the most important thing is that it will seriously threaten the life safety of patients.

Method used

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  • Nanofiber-reinforced absorbable intraosseous fixation material and preparation method thereof
  • Nanofiber-reinforced absorbable intraosseous fixation material and preparation method thereof
  • Nanofiber-reinforced absorbable intraosseous fixation material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] In Example 1, the nanofiber-reinforced absorbable bone internal fixation material is composed of polyglycolide-lactide copolymer nanofibers, polyglycolide-lactide copolymer pellets, and β-tricalcium phosphate; , the consumption of polyglycolide-lactide copolymer nanofiber is 15g, the consumption of polyglycolide-lactide copolymer pellet is 65g, the consumption of β-tricalcium phosphate is 20g.

[0037] The preparation process is:

[0038] 1. Using electrospinning technology to prepare polyglycolide-lactide copolymer nanofibers, specifically including: adding polyglycolide-lactide high-molecular polymers into a solvent, performing magnetic stirring, and serving as an electrospinning solution; Adding the prepared electrospinning solution into the nozzle for electrospinning to obtain polyglycolide-lactide copolymer nanofibers;

[0039] The concentration of the electrospinning solution was 20%, the magnetic stirring time was 6 h, the electrospinning voltage was 20 kV, the ...

Embodiment 2

[0045] The nanofiber-reinforced absorbable bone internal fixation material is composed of polylactic acid nanofibers, polyglycolide-lactide copolymer pellets, and β-tricalcium phosphate artificial bone material; wherein, the dosage of polylactic acid nanofibers and nanofibers is 15g, the dosage of polyglycolide-lactide copolymer pellets is 65g, and the dosage of β-tricalcium phosphate artificial bone material is 20g.

[0046] The preparation process is:

[0047] 1. Using electrospinning technology to prepare polylactic acid nanofibers, specifically including: adding polylactic acid polymers to chloroform solvents, performing magnetic stirring, as an electrospinning solution; adding the prepared electrospinning solution to the nozzle, Electrospinning is carried out to obtain polylactic acid nanofibers;

[0048] The concentration of the electrospinning solution was 20%, the magnetic stirring time was 6 h, the electrospinning voltage was 20 kV, the propulsion speed of the spinni...

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Abstract

The invention provides a nanofiber-reinforced absorbable intraosseous fixation material and a preparation method thereof. The nanofiber-reinforced absorbable intraosseous fixation material is mainly formed by compounding a biodegradable polymer material, nanofibers and an artificial bone material, wherein the surfaces of the nanofibers are modified; the content of the nanofibers accounts for 10-20% of the total weight of the material; the content of the biodegradable polymer material accounts for 60-80% of the total weight of the material; and the artificial bone material accounts for 10-20% of the total weight of the material. The nanofiber-reinforced absorbable intraosseous fixation material disclosed by the invention overcomes the defect that a common intraosseous fixation material is prone to multi-scale fracture; the nanofibers have the characteristics of large specific surface, high porosity, strong modification capability and high elastic modulus; the mechanical properties of the absorbable intraosseous fixation material is greatly improved; meanwhile, bone absorption and bone ingrowth are also further promoted; and the postoperative recovery process is accelerated.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a nanofiber-reinforced absorbable bone internal fixation material and a preparation method thereof. Background technique [0002] With the iterative update of medical technology, although traditional metals have high mechanical strength and fatigue resistance, which can meet the performance requirements of clinical operations, metal materials cannot be degraded in the body after they are implanted into the human body. Afterwards, a second operation is required to remove it, causing secondary injury to the patient. In recent years, absorbable fixed grafts have received extensive attention due to their unique advantages, but there are also a series of problems, but compared with other non-absorbable materials, they also have certain limitations, such as poor crack resistance, low toughness, and brittleness. Obviously, the degradation rate is not consistent with the bone ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/14B29C45/00D01D5/00D01D5/247
CPCA61L31/127A61L31/129A61L31/14A61L31/146A61L31/148B29C45/00D01D5/003D01D5/247C08L67/04
Inventor 董文兴赵树宇杨腾飞
Owner STAR SPORTS MEDICINE CO LTD
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