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166results about How to "Strong modifiability" patented technology

Mesoporous nano silicon ball compound targeting drug delivery system as well as preparation method and application thereof

The invention relates to a mesoporous nano silicon ball compound targeting drug delivery system as well as a preparation method and application thereof. The preparation method of the mesoporous nano silicon ball compound targeting drug delivery system comprises the following steps: 1) preparing amino-functionalized drug loading mesoporous silicon dioxide microspheres; 2) preparing hyaluronic acid-hydrosulphonyl polypeptide-adriamycin (HA-RGD-DOX); 3) preparing mesoporous microsphere-hyaluronic acid-hydrosulphonyl polypeptide-adriamycin--paclitaxel (MSNs-HA-RGD-DOX_PTX); and 4) preparing fluorescent marker modified mesoporous microsphere-hyaluronic acid-hydrosulphonyl polypeptide-adriamycin--paclitaxel compound (MSNs-HA-RGD-DOX-PTX). The mesoporous nano silicon ball compound targeting drug delivery system has the beneficial effects that firstly multi-targeting synergistic drug delivery is realized, multiple tumour cells and tissues can be killed, and reversal drug resistance is good; secondly, blood stability is excellent; thirdly, invisibility, drug release degree and controlled release properties are good; fourthly, in vivo tracing function is good; and fifthly, the mesoporous nano silicon ball compound targeting drug delivery system has good general applicability.
Owner:WUHAN UNIV OF TECH

A universal analysis method for a serial communication information protocol

The invention belongs to the field of product test, analysis and evaluation software, and discloses a universal analysis method for a serial communication information protocol, which comprises the following steps of: 1, filling a configuration parameter file according to the communication information protocol; 2, searching a frame header identifier; 3, judging whether a frame header identifier isfound or not; 4, intercepting the protocol byte length of the communication information from the frame header identifier, and judging whether the number of bytes from the frame header identifier to the end of the to-be-analyzed data is smaller than the protocol byte length or not; 5, verifying and judging the communication information protocol; 6, reading the i-th variable, and sequentially analyzing the characteristic parameters of the i-th variable; and 7, judging whether the i-th variable is the last variable information or not. According to the method, the analysis process of the serial port communication information protocol is greatly simplified, the compiling process of different communication protocol analysis software is cancelled, the readability of the communication protocol isimproved, the error rate of the analysis process is effectively reduced, and the efficiency in the debugging work process is remarkably improved.
Owner:西安现代控制技术研究所

Contrast medium used for glioma targeted magnetic resonance and fluorescence dual modality imaging, and preparation method thereof

The invention provides a contrast medium used for glioma targeted magnetic resonance and fluorescence dual modality imaging, and a preparation method thereof. The contrast medium is composed of an acrylamide monomer, an allyl monmer containing sulfhydryl or carboxyl or amidogen, superparamagnetic iron oxide nanoparticles, a fluorochrome and lactoferrin. The preparation method comprises following steps: the acrylamide monomer and the allyl monmer containing sulfhydryl or carboxyl or amidogen are subjected to polymerization reaction so as to obtain a copolymer nanogel; the superparamagnetic iron oxide nanoparticles are added in polymerization reaction process so as to obtain a superparamagnetic copolymer nanogel; the fluorochrome and lactoferrin and combined via covalent bonds so as to obtain fluorochrome labeled lactoferrin; and the superparamagnetic copolymer nanogel and fluorochrome labeled lactoferrin are combined via covalent bonds so as to obtain the contrast medium used for glioma targeted magnetic resonance and fluorescence dual modality imaging. The contrast medium possesses characteristics such as high specificity, selectivity and contrast effect, and low toxic and side effect; and is capable of realizing dual modality imaging.
Owner:HUAZHONG UNIV OF SCI & TECH

Automatic detection and early warning system for numerical control machine tool and operation method of automatic detection and early warning system

The invention relates to an automatic detection and early warning system for a numerical control machine tool and the operation method of the automatic detection and early warning system. The automatic detection and early warning system comprises an input unit, a transmission unit, an analysis and calculation unit, a coordinate detection unit, a coordinate comparison unit and an alarm unit. The input unit is used for reading a processing program into a machine tool, andconverting the processing program into a readable analog signal. The analysis and calculation unit is used for reading the processing program, andcalculating a theoretical coordinate value. The transmission unit is used for driving the mechanical part of the machine tool to move through the readable analog signal. The coordinate detection unit is used for detecting the actual coordinate value of the mechanical part of the machine tool in real time. The coordinate comparison unit is used for comparing the theoretical coordinate value with the actual coordinate value. If the difference value between the theoretical coordinate value and the actual coordinate valueis within the range of a threshold value A, the numericalcontrol machine tool works normally. Otherwise, the alarm unit is started to give an alarm. According to the invention, the program data can be analyzed in advance when the system works normally. Theon-line real-time detection is carried out, and the machining state is monitored in real time. The tool damage of the numerical control machine tool can be effectively prevented, and the operation safety and the operation reliability are improved.
Owner:WEIFANG UNIVERSITY

Preparation and application of a same-energy rare earth luminescent probe based on change of luminescence lifetime

The invention relates to the technical field of bio-imaging, in particular to preparation and application of a same-energy rare earth luminescent probe based on change of luminescence lifetime. The rare earth luminescence lifetime probe comprises a luminescent donor Ln, an energy acceptor Qe and a linking material Link, the general structural formula is Ln-Link-Qe, and the luminescent donor is composed of rare earth nanoparticles, wherein energy absorption and fluorescence emission occur at the same electronic state energy level; the energy acceptor is matched with the luminescence wave band of the rare earth nanoparticles, and the energy transfer process occurs, so that the fluorescence lifetime is changed; and combination of the luminescent donor and the energy acceptor is performed through the linking material in an electrostatic adsorption, covalent coupling or twining mode, so that energy transfer is promoted. The luminescence process of the rare earth luminescent donor of the probe conforms to the first-order reaction kinetics, and the number of the energy acceptor of the probe relative to the luminescent donor is linear to the fluorescence lifetime of the rare earth material, so that the lifetime signal is utilized, and target detection in a complex environment is achieved; and great application prospects in the field of biological detection is achieved.
Owner:FUDAN UNIV

Shear wall fire exposure testing device under vertical load effect

The invention discloses a shear wall fire exposure testing device under the vertical load effect, relates to a fire resistance testing device, and belongs to the technical field of building structure disaster prevention and reduction. The shear wall fire exposure testing device comprises a furnace body, a loading system, an information collection system and a combustion control system. The furnace body is formed by assembling a shear wall component, a furnace side wall and a furnace top cover through bolts and screws. The furnace side wall and the furnace top cover fix zirconium-containing refractory fiber modules to a steel plate by means of stainless steel anchoring parts. The assembling efficiency is high, the modifiability is good, the containment furnace wall can be modified according to different test piece sizes, the repeated utilization factor is high, waste is reduced, a vertical placement shear wall fire resistance test under the axial pressure is achieved, and real working conditions of test pieces can be simulated; an intelligent ratio adjuster and an electric actuator are used for achieving automatic control over the furnace temperature; the shear wall test piece and the furnace wall are combined into the furnace body, one or more shear walls can be synchronously tested, the test data discreteness is lowered, and the purpose of saving energy is achieved.
Owner:NORTH CHINA UNIV OF WATER RESOURCES & ELECTRIC POWER

Thiophene organic semiconductor material and preparation method and application thereof

The invention belongs to the field of photoelectronic materials, and discloses a thiophene organic semiconductor material and a preparation method and application thereof. The copolymer has a general formula (P), wherein in the formula, x+y is equal to 2; x is more than or equal to 1, and y is more than 0 and is less than 1; n is more than 1 and is less than or equal to 100; R1 and R4 are alkyl having 1 to 20 carbon atoms; and R2 and R3 are hydrogen and alkyl having 1 to 20 carbon atoms or phenyl substituted by alkyl having 1 to 20 carbon atoms or alkoxy having 1 to 20 carbon atoms or are thephenyl. Compared with the prior art, the invention has the advantages that: the organic semiconductor material is prepared by polymerizing a cyclopentadiene [2,1-b:3,4-b'] bithiophene unit, a thiophene unit and a quinoxaline unit, so the carrier mobility of the organic semiconductor material is increased, spectral response is broadened, and the organic semiconductor material has high carrier transmission property and electrochemical property; and the alkyl and the like can be introduced by a simple and convenient method to improve solubility. The preparation process of the semiconductor material is simple and easy to operate and control, and is suitable for industrial production.
Owner:OCEANS KING LIGHTING SCI&TECH CO LTD +1

Multichannel animation demonstration method and system and smart television

The invention discloses a multichannel animation demonstration method and system and a smart television. The method comprises the steps of after the smart television is started, judging whether a demonstration mode is triggered or not according to a demonstration animation switching state; and when it is detected that the demonstration mode is triggered, obtaining a demonstration animation and a playing parameter, controlling operation of a transparent background layer of an upper playing layer of a currently played television master image of the smart television, playing the demonstration animation on the transparent background layer according to the playing parameter, and controlling the current television master image to be continuously played on the playing image of the smart television. According to the method, the system and the smart television, the television master image of the television and a demonstration animation signal can be played at the same time; the television master image and the demonstration animation signal are operated at the same time and do not influence each other; the demonstration animation is watched, and moreover, the playing of the television image is not influenced; and the convenience is provided for a user.
Owner:SHENZHEN SKYWORTH RGB ELECTRONICS CO LTD

PH (potential of hydrogen) responsive magnetic meso-porous silicon nano-particle drug controlled release system and preparation method thereof

The invention provides a pH (potential of hydrogen) responsive magnetic meso-porous silicon nano-particle drug controlled release system and a preparation method thereof. A structure of the drug controlled release system includes that the system is of a double-layer structure, the inner layer of the system is provided with a drug-loading magnetic meso-porous silicon nano-particle, the outer layerof the system is provided with a branched polyethyleneimine, the branched polyethyleneimine of the outer layer is treated by methylmaleic anhydride, the magnetic meso-porous silicon nano-particle is of a core-shell structure, a core is provided with a ferroferric oxide nano-particle, and a loaded drug is doxorubicin hydrochloride. The system has magnetic responsiveness, cell tracing is achieved, disease conditions are accurately diagnosed in real time, targeted delivery and controlled release of the drug is synchronously achieved, amidated PEI wraps surface of MMSN through GSH (glutathione) sensitive disulfide bonds, so that 'passive targeting' enrichment of acid response of a tumor microenvironment is achieved, step-by-step response is achieved by the aid of a mechanism of pH sensitivityand GSH sensitivity, high-accuracy targeted therapy of a cancer is achieved, and the cancer is effectively and integrally diagnosed and treated.
Owner:HUBEI UNIV
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