17results about How to "Strong modifiability" patented technology

The invention discloses an intelligent conference system, relates to the field of data encryption, and is used for solving the problems that in a scene of frequent modification and multi-person cooperation, a trace of multi-person simultaneous modification or supplementation exists in document content, so that keys are inconsistent or versions are conflicted, and documents cannot be accessed or are lost. File feature information and conference feature information are collected, a data analysis model is established, merging evaluation coefficients are obtained, the merging evaluation coefficients are compared and calculated, differences of the merging evaluation coefficients are obtained, trend analysis and calculation are conducted on the differences, a document key total trend is obtained and compared with a merging threshold value, and a comparison result is obtained. According to the method, a time sequence model is established, the merging degree of the current document key is limited according to the time sequence model, key security prediction analysis is carried out through the time sequence model according to a limiting result, security performance data is obtained, a key merging scheme is dynamically adjusted, key conflicts and data loss are avoided, and it is guaranteed that the document data security is lasting.

The utility model provides an automatic plugging self-locking type positioning mechanism for a robot, which is characterized in that a pin head is inserted and fixed at the top end of a pin body, a pin tail is inserted and fixed at the bottom end of the pin body, a self-locking hook pin groove is arranged on the outer surface of the pin tail, a self-locking hook pin is connected in the self-locking hook pin groove through two self-locking hook pin grooves, and the self-locking hook pin is inserted and fixed at the bottom end of the pin body. The two telescopic springs are arranged between the self-locking hook pin and the self-locking hook pin groove and are arranged on the two spring fastening screws in a sleeving mode respectively, a clamping structure is arranged at the bottom of the self-locking hook pin, and the self-locking hook pin shrinks inwards into the self-locking hook pin groove and then is inserted into a tray positioning hole in the clamp body when being extruded by external force; the self-locking hook pin extends outwards to be separated from the self-locking hook pin groove when being not extruded by external force, so that the clamping structure at the bottom of the self-locking hook pin is clamped with the tray positioning hole of the clamp body; according to the mechanism, the positioning mechanism can be installed on the clamp body when used and automatically locked, the mechanism can be integrated with a robot automation system, and automatic unmanned replacement of the positioning mechanism is achieved.

The application belongs to the technical field of biological medicine, and particularly relates to a polypeptide degradation agent for targeted degradation of CD26 and a preparation method and application thereof. The polypeptide degradation agent is obtained after coupling of a tetrapeptide and lenalidomide. The amino acid sequence of the tetrapeptide is any one of SEQ ID NO. 1 and SEQ ID NO. 2. The polypeptide degradation agent can specifically target and degrade DPP4, i.e. CD26, but cannot degrade DPP4 isozymes such as DPP7, DPP8 and DPP9, and thus has high selectivity. In addition, the polypeptide degradation agent has small molecular weight, one end is a natural short peptide, has good tissue compatibility, can quickly degrade target proteins in 6 hours, and thus has good tissue permeability.

This invention discloses an efficient QR matrix decomposition method based on FPGA for implementing systolic matrices, belonging to the field of software-defined radio signal transmission technology for airborne networks. It is based on the design of a multi-channel digital front-end implemented on an FPGA chip. The method includes: designing a general handshake coordination mechanism, designing a timing flow for systolic matrix multiplication, performing fast QR matrix decomposition single-loop operations by calculating the Householder mirror transformation matrix, designing a top-level loop pipeline for QR matrix decomposition, and finally verifying the hardware scheme of the fast QR decomposition algorithm. This invention converts resource consumption into timing consumption by designing the overall pipeline logic and loop operations, enabling fast processing and accurate decomposition of digital information in a multi-channel digital front-end on an FPGA, effectively saving on-chip resources. In addition, this invention has excellent scalability, supporting 64 to 128-bit high-precision fixed-point number formats, and the data matrix order can reach up to 128.

The embodiment of the application provides a double-sweet-spot prediction method and device for a geological reservoir, which comprises the following steps: obtaining a plurality of to-be-analyzed regions according to the three-dimensional distribution information of a double-sweet-spot index of a target reservoir, and obtaining the fracture propagation simulation result corresponding to the to-be-analyzed region; based on the established three-dimensional geological model of the target reservoir, according to the distribution information of the aquifer and the distribution information of the thin interlayer in the three-dimensional geological model of the target reservoir, and through the fracture propagation simulation result corresponding to the to-be-analyzed region, the to-be-analyzed region is marked as a double-sweet-spot region after it is determined that the fracture of the to-be-analyzed region will not communicate with the aquifer and can pass through the thin interlayer; and all double-sweet-spot regions are obtained by traversing the plurality of to-be-analyzed regions of the target reservoir, so as to complete the double-sweet-spot prediction of the target reservoir. By simultaneously considering the distribution information of the complex geological structure of the aquifer and the thin interlayer and the fracture propagation characteristics, the precision of the double-sweet-spot region prediction is improved, and the economy of the reservoir development is improved.

The application discloses a preparation method of amino-modified magnetic microspheres, which comprises the following steps: modifying the surface of magnetic nanoparticles to obtain magnetic microspheres with double bonds on the surface; performing a polymerization reaction on the surface of the magnetic microspheres to form core-shell magnetic beads with a surface polymer; and performing an amino-modification treatment on the core-shell magnetic beads to form amino-modified magnetic microspheres. The magnetic microspheres have strong magnetism, uniform particle size distribution, regular morphology, and small batch difference, and the sensitivity of magnetic bead extraction is greatly improved.

This invention relates to the field of biomedical technology, and more particularly to a PD-L1-targeting polypeptide, its conjugate, and its applications. The polypeptide possesses the amino acid sequence shown in SEQ ID NO.1 or SEQ ID NO.2. This invention de novo designs a high-affinity PD-L1-targeting specific polypeptide. This polypeptide achieves extremely high affinity with the extracellular domain of the PD-L1 protein through its unique spatial conformation, exhibiting excellent targeting and recognition capabilities. The polypeptide provided by this invention can be conjugated with various modified molecules, such as radionuclides, and the constructed molecular imaging probe exhibits excellent tumor tissue targeting and enrichment capabilities, superior biocompatibility, and clear imaging contrast, enabling specific recognition of PD-L1-positive tumor lesions. It can be applied to clinical scenarios such as early precision diagnosis of tumors, screening of patients for immunotherapy, real-time monitoring of efficacy, and prognostic assessment, possessing significant translational medical value and broad application prospects.

The invention provides a photosensitive amphiphilic expanded microsphere and a preparation method thereof. The photosensitive amphiphilic expanded microsphere provided by the invention comprises a thermoplastic shell, alkane gas coated in the shell and an azide naphthoquinone group grafted on the surface of the shell. The photoisomerization reaction is utilized to enable the expanded microspheres to have the characteristics of photosensitivity and amphipathy, in the process of synthesizing the expanded microspheres, inorganic dispersants such as silicon dioxide, magnesium hydroxide and hydroxy calcium phosphate used in the synthesis of the expanded microspheres are not used, and the modifiability of the microspheres is improved; and the hydrophilic-oleophylic conversion of the microspheres can be realized by controlling the illumination time.

The invention relates to a heteroatom-doped asymmetric coordination structure oxygen reduction catalyst as well as a preparation method and application thereof, and belongs to the technical field of electrochemical oxygen reduction catalysis. The preparation method of the catalyst comprises the following steps: S1, dissolving an iron source and a zinc source in an organic solvent, stirring and dissolving, and performing ultrasonic treatment to obtain a solution A; s2, dissolving 2-methylimidazole and a ligand containing heteroatoms in an organic solvent to obtain a solution B; s3, pouring the solution B into the solution A, reacting at room temperature, centrifugally collecting a product, and drying to obtain precursor powder; and S4, performing pyrolysis treatment on the precursor powder to obtain the catalyst. The MOF carrier has the advantages of good ligand modifiability, coordination topology and the like, and high-dispersion, high-load and high-precision doping of heteroatoms can be achieved by adjusting the types, proportion and number of the ligands containing the heteroatoms in the synthesis process.

The present application relates to the technical fields of biological medicine and gene therapy, and particularly relates to a protonatable cationic lipid, a nucleic acid delivery system and application thereof. The protonatable cationic lipid has a structure as shown in formula (I), and contains a protonatable group such as a hydroxyl group or an amino group at the end. The protonatable cationic lipid can form a lipid nanoparticle for loading various nucleic acid substances. The lipid nanoparticle nucleic acid delivery system has high cell transfection efficiency in vitro, and can be targeted to organs such as liver in vivo to achieve efficient gene editing. The lipid nanoparticle constructed by the protonatable cationic lipid provided by the present application has high encapsulation efficiency, good stability and excellent delivery efficiency, and has a wide application prospect in the fields of gene therapy and cell engineering.

The present invention discloses a smart conference system, which relates to the field of data encryption and is used to solve the problem that in a scenario of frequent modification and multi-person collaboration, there are traces of simultaneous modification or supplementation of document content by multiple people, which will lead to inconsistent keys or version conflicts, and the document is inaccessible or lost. File feature information and conference feature information are collected, a data analysis model is established, a merging evaluation coefficient is obtained, and the difference of each merging evaluation coefficient is obtained, and trend analysis and calculation are performed to obtain the overall trend of the document key, and the difference is compared with a merging threshold to obtain a comparison result, and the merging degree of the document key is limited based on the comparison result, and based on the limited result, a key security prediction analysis is performed through a time series model to obtain security performance data, and a key merging scheme is dynamically adjusted to avoid key conflicts and data loss, so as to ensure the long-term security of document data.

The invention discloses a high-selectivity terahertz metasurface biosensor based on a modified single-walled carbon nanotube film. The single-walled carbon nanotube metasurface layer is provided with a periodic opening resonance ring structure in an etched mode, is purified through strong acid, tip ultrasound, high-speed centrifugation, heat treatment and other schemes and is doped with gold nanoparticles from bottom to top in sequence. The invention also discloses an application of the high-selectivity terahertz metasurface biosensor based on the modified single-walled carbon nanotube film. The problems that in the prior art, a terahertz metasurface trace substance sensor is poor in modifiability, and high-selectivity sensing of trace substances cannot be achieved are solved.

The application discloses a kind of MOF / rGO composite aerogel and its preparation method and use, the preparation method includes the following steps: middle-four (4-carboxyl phenyl) porphyrin and zirconium oxychloride are dissolved in N,N-dimethylformamide to form solution A, then add difluoroacetic acid to solution A to form solution B, solution B is transferred to reaction kettle to carry out solvothermal reaction, after natural cooling, obtain uniform suspension, centrifugal cleaning obtains PCN-222;Graphene oxide is dispersed in water to form suspension C;PCN-222 powder is obtained and a certain amount of suspension C is mixed evenly, then a certain amount of ascorbic acid is added, and after dissolving, suspension D is formed;Suspension D is placed in water bath kettle for constant temperature treatment for a certain time, to obtain MOF / rGO composite hydrogel;After washing hydrogel, freeze-drying and low-temperature annealing obtain MOF / rGO composite aerogel.The MOF / rGO composite aerogel prepared by the method is mainly applied to glyoxylic acid decolorizing material.

The present application relates to a kind of ice load calculation method based on discrete element under the action of ship and ice ridge, according to the sea area where ice ridge is located, the sea ice discrete element unit model of particle unit with corresponding cohesion effect of mass and size is established;Based on the buoyancy method, the discrete element model of ice ridge is generated by combining sea ice discrete element unit;The entire ship surface is discretized into a series of triangular units using grid division preprocessing, and the contact model between the discrete triangular units of the ship body and the spherical sea ice discrete element units is established;Dynamic calculation and analysis of ice load on the interaction between spherical sea ice discrete element units and discrete triangular units of the ship body;Parallel programming based on GPU is realized on CUDA platform using discrete element method, which realizes fast modeling of ice ridge model and ice load calculation under the dynamic action of ship-ice ridge.It greatly reduces the modeling difficulty of ice ridge, and improves the reusability and modifiability of ice ridge model.

The invention relates to a composite aerogel type oxygen reduction catalyst and a preparation method and application thereof.According to the composite aerogel type oxygen reduction catalyst and the preparation method and application thereof, the composite proportion of gamma-GY and MWCNT and doping of nitrogen heteroatoms are accurately controlled, and hydrothermal reaction conditions are optimized; the gamma-GY / MWCNT composite aerogel type oxygen reduction catalyst which shows remarkable advantages and breakthrough in the aspects of structure, performance, synthesis process and the like is prepared. Compared with the prior art, the method is simple to operate, low in cost and easy to realize large-scale production. The prepared aerogel catalyst combines the advantages of the carbon nanomaterial and the aerogel, has high specific surface area and mesoporous structure, and excellent oxygen reduction catalytic performance and stability, and can be used as a fuel cell cathode catalyst.

The invention discloses an aza-biaryl compound, a preparation method thereof and an application of the aza-biaryl compound in preparation of an aza-helicene compound, the aza-biaryl compound has the following structural general formula: # imgabs0 #, in which R1 is selected from one of hydrogen, alkyl, alkoxy and substituted or unsubstituted phenyl, or is cyclized with any two adjacent sites of aza-biaryl to form a benzene ring; ar is substituted aryl; and R3 is selected from hydrogen, substituted alkyl and substituted phenyl. The aza-biaryl compound can be prepared by reacting bromine-substituted benzoquinoline, aryl iodide and alkyne in the presence of a palladium catalyst, an organic ligand, an alkali reagent and a solvent through multi-component C-H activation series connection. A series of aza-helicene compounds can be prepared from the compound through one-step catalytic cyclization of a platinum catalyst or an acid catalyst. The preparation method has the advantages of simple steps, mild reaction, easily available raw materials and good substrate universality, and can efficiently construct the aza-biaryl compound and the aza-helicene compound.

The invention discloses a fluorescent natural rubber composite material, which is prepared by mixing natural rubber, stearic acid, zinc oxide, an accelerant M, sulfur and organic luminescent crystals in an open mill, uniformly mixing the rubber material and a filler, calendering to form sheets, and vulcanizing at 120-150 DEG C to obtain the fluorescent natural rubber composite material. After the organic light-emitting crystals are mixed with the natural rubber matrix, the natural rubber can be endowed with fluorescence performance, meanwhile, the organic light-emitting crystals can generate certain interaction with the natural rubber, and the tensile strength, the fracture performance and the wear resistance of the natural rubber are further improved.