7results about How to "Strong modifiability" patented technology

The application belongs to the technical field of biological medicine, and particularly relates to a polypeptide degradation agent for targeted degradation of CD26 and a preparation method and application thereof. The polypeptide degradation agent is obtained after coupling of a tetrapeptide and lenalidomide. The amino acid sequence of the tetrapeptide is any one of SEQ ID NO. 1 and SEQ ID NO. 2. The polypeptide degradation agent can specifically target and degrade DPP4, i.e. CD26, but cannot degrade DPP4 isozymes such as DPP7, DPP8 and DPP9, and thus has high selectivity. In addition, the polypeptide degradation agent has small molecular weight, one end is a natural short peptide, has good tissue compatibility, can quickly degrade target proteins in 6 hours, and thus has good tissue permeability.

This invention discloses an efficient QR matrix decomposition method based on FPGA for implementing systolic matrices, belonging to the field of software-defined radio signal transmission technology for airborne networks. It is based on the design of a multi-channel digital front-end implemented on an FPGA chip. The method includes: designing a general handshake coordination mechanism, designing a timing flow for systolic matrix multiplication, performing fast QR matrix decomposition single-loop operations by calculating the Householder mirror transformation matrix, designing a top-level loop pipeline for QR matrix decomposition, and finally verifying the hardware scheme of the fast QR decomposition algorithm. This invention converts resource consumption into timing consumption by designing the overall pipeline logic and loop operations, enabling fast processing and accurate decomposition of digital information in a multi-channel digital front-end on an FPGA, effectively saving on-chip resources. In addition, this invention has excellent scalability, supporting 64 to 128-bit high-precision fixed-point number formats, and the data matrix order can reach up to 128.

The embodiment of the application provides a double-sweet-spot prediction method and device for a geological reservoir, which comprises the following steps: obtaining a plurality of to-be-analyzed regions according to the three-dimensional distribution information of a double-sweet-spot index of a target reservoir, and obtaining the fracture propagation simulation result corresponding to the to-be-analyzed region; based on the established three-dimensional geological model of the target reservoir, according to the distribution information of the aquifer and the distribution information of the thin interlayer in the three-dimensional geological model of the target reservoir, and through the fracture propagation simulation result corresponding to the to-be-analyzed region, the to-be-analyzed region is marked as a double-sweet-spot region after it is determined that the fracture of the to-be-analyzed region will not communicate with the aquifer and can pass through the thin interlayer; and all double-sweet-spot regions are obtained by traversing the plurality of to-be-analyzed regions of the target reservoir, so as to complete the double-sweet-spot prediction of the target reservoir. By simultaneously considering the distribution information of the complex geological structure of the aquifer and the thin interlayer and the fracture propagation characteristics, the precision of the double-sweet-spot region prediction is improved, and the economy of the reservoir development is improved.

The application discloses a preparation method of amino-modified magnetic microspheres, which comprises the following steps: modifying the surface of magnetic nanoparticles to obtain magnetic microspheres with double bonds on the surface; performing a polymerization reaction on the surface of the magnetic microspheres to form core-shell magnetic beads with a surface polymer; and performing an amino-modification treatment on the core-shell magnetic beads to form amino-modified magnetic microspheres. The magnetic microspheres have strong magnetism, uniform particle size distribution, regular morphology, and small batch difference, and the sensitivity of magnetic bead extraction is greatly improved.

This invention relates to the field of biomedical technology, and more particularly to a PD-L1-targeting polypeptide, its conjugate, and its applications. The polypeptide possesses the amino acid sequence shown in SEQ ID NO.1 or SEQ ID NO.2. This invention de novo designs a high-affinity PD-L1-targeting specific polypeptide. This polypeptide achieves extremely high affinity with the extracellular domain of the PD-L1 protein through its unique spatial conformation, exhibiting excellent targeting and recognition capabilities. The polypeptide provided by this invention can be conjugated with various modified molecules, such as radionuclides, and the constructed molecular imaging probe exhibits excellent tumor tissue targeting and enrichment capabilities, superior biocompatibility, and clear imaging contrast, enabling specific recognition of PD-L1-positive tumor lesions. It can be applied to clinical scenarios such as early precision diagnosis of tumors, screening of patients for immunotherapy, real-time monitoring of efficacy, and prognostic assessment, possessing significant translational medical value and broad application prospects.

The present application relates to the technical fields of biological medicine and gene therapy, and particularly relates to a protonatable cationic lipid, a nucleic acid delivery system and application thereof. The protonatable cationic lipid has a structure as shown in formula (I), and contains a protonatable group such as a hydroxyl group or an amino group at the end. The protonatable cationic lipid can form a lipid nanoparticle for loading various nucleic acid substances. The lipid nanoparticle nucleic acid delivery system has high cell transfection efficiency in vitro, and can be targeted to organs such as liver in vivo to achieve efficient gene editing. The lipid nanoparticle constructed by the protonatable cationic lipid provided by the present application has high encapsulation efficiency, good stability and excellent delivery efficiency, and has a wide application prospect in the fields of gene therapy and cell engineering.

The application discloses a kind of MOF / rGO composite aerogel and its preparation method and use, the preparation method includes the following steps: middle-four (4-carboxyl phenyl) porphyrin and zirconium oxychloride are dissolved in N,N-dimethylformamide to form solution A, then add difluoroacetic acid to solution A to form solution B, solution B is transferred to reaction kettle to carry out solvothermal reaction, after natural cooling, obtain uniform suspension, centrifugal cleaning obtains PCN-222;Graphene oxide is dispersed in water to form suspension C;PCN-222 powder is obtained and a certain amount of suspension C is mixed evenly, then a certain amount of ascorbic acid is added, and after dissolving, suspension D is formed;Suspension D is placed in water bath kettle for constant temperature treatment for a certain time, to obtain MOF / rGO composite hydrogel;After washing hydrogel, freeze-drying and low-temperature annealing obtain MOF / rGO composite aerogel.The MOF / rGO composite aerogel prepared by the method is mainly applied to glyoxylic acid decolorizing material.