Chimeric antigen receptor, chimeric antigen receptor umbilical cord blood karyocyte and application

A chimeric antigen receptor and umbilical cord blood technology, which is applied in the field of umbilical cord blood nucleated cells and its preparation, can solve the problem that the killing effect of solid tumors cannot meet the expected requirements, and achieve efficient and specific killing, targeting and killing effects strong effect
CN112480266AActive Publication Date: 2021-03-12GZ CEDICINE BIOTECH CO LTD
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
GZ CEDICINE BIOTECH CO LTD
Publication Date
2021-03-12

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Abstract

The invention provides a high-affinity chimeric antigen receptor targeting EGFRvIII, the chimeric antigen receptor is formed by mutation of a chimeric antigen receptor commonly used at present and targeting EGFRvIII, and the amino acid sequence of the chimeric antigen receptor is shown as SEQ ID NO: 1. The invention further provides an umbilical cord blood karyocyte containing the chimeric antigenreceptor, which can efficiently target an EGFRvIII antigen through the chimeric antigen receptor, has stronger capability of killing EGFRvIII positive tumor cells, and can be used for preparing medicines for preventing and treating various EGFRvIII positive tumors.
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Description

technical field

[0001] The invention relates to the field of tumor cell therapy, in particular to a chimeric antigen receptor targeting EGFRvIII, umbilical cord blood nucleated cells expressing the chimeric antigen receptor, and a preparation method and application thereof. Background technique

[0002] From the perspective of tumorigenesis, tumor cells are transformed from normal cells. This process from "self" to "non-self" is often monitored by the body's immune system and eliminated by an effective immune response. In recent years, due to the rapid development and cross-infiltration of theories and technologies in oncology, immunology, cytology, molecular biology and other related disciplines, with the in-depth understanding of the body's anti-tumor immune response, as well as the understanding of tumor immune escape mechanisms and tumor microbiology. With an in-depth understanding of the environment, new strategies and new ideas for tumor immunotherapy have been further...

Claims

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