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Granules for treating fatty liver and alcoholic liver injury and preparation method

A technology for alcoholic liver injury and fatty liver, which is applied in the field of granules and preparation for the treatment of fatty liver and alcoholic liver injury, can solve the problems of substandard melting test, unstable feeding quantity, unfixed quantity, etc. The effect of arterial circulation, inhibition of thrombosis and alleviation of liver damage

Inactive Publication Date: 2021-03-26
TONGHUA GOLDEN-HORSE PHARM IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its disadvantages are: 1. Most of the hawthorn medicinal materials contain fruit stones, which are ineffective ingredients, accounting for a large proportion, and the quantity is not fixed, resulting in unstable feeding quantity, and there are differences between batches
Caused the invention to fail to meet the standards in the solubility test

Method used

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  • Granules for treating fatty liver and alcoholic liver injury and preparation method
  • Granules for treating fatty liver and alcoholic liver injury and preparation method
  • Granules for treating fatty liver and alcoholic liver injury and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A particle for therapeutic fatty liver and alcoholic liver injury (referred to as new prescription), made from the weight of the raw material drug: Jiao Hawthorn 150g, Yinchen (Celantia) 100g, Alisma 100g, car front grass 75g 75g of tigpes, salviases 100g, cooked rhubarb 45g, cassia 75g, astragalus 100g, Bupleurum 75g, Polygonum 75g, plus conventional excipients for 1000g.

Embodiment 2

[0049] A process for the treatment of fatty liver and alcoholic liver injury particles (referred to as new processes), which are as follows:

[0050] 1 The above unesen flavor, Jiao Hawthorn, Danshen discretion, and heated with ethanol and reflux three times.

[0051] 2 Add 10 times the first time to 95% ethanol, reflux for 2 hours, the second plus 8 times the amount of 95% ethanol, reflow 1.5 hours, the third plus 8 times 95% ethanol, reflux for 1 hour, filtered separately , The filtrate is combined, and the ethanol is recovered and concentrated to a relative density of 1.10, temperature 70 ° C, spare.

[0052] 3 Pharmaceutical and Yinchen, etc., the remaining nine flavor plus water, add 10 times the amount of water in the first time, decorate 2 hours, add 8 times the amount of water in the second time, decorate 1.5 hours, the third time plus 8 times Water, decoction for 1 hour, filtered, combined with filtrate, concentrated to a relative density of 1.10 temperature 70 ° C.

[00...

experiment example 1

[0057] Three batch of inventions (Y20191001, Y20191002, Y20191003) were selected according to the original prescription and process preparation, respectively. See Examples 1, 2.

[0058] The "Chinese Pharmacopoeia" was measured by high performance liquid chromatography (generally 0512). Detection of aloe vera alin (C 15 Hide 10 O 5 Qiomelic acid (C 15 Hide 8 O 6 ), Qi (C 15 Hide 10 O 5 ), Large cranium (C 15 Hide 10 O 4 ) And large tantin methyl ether (C 16 Hide 12 O 5 The total amount.

[0059] Instrument: Waters High Performance Liquid Chromatograph Model: E2695 / 2489; UV detector. Electronic Analysis Balance, Model: BS124S. Electronic analysis balance, model: AE240. CNC Ultrasonic Cleanner, Model: KQ-250DE.

[0060] Suitability test of chromatographic conditions and system

[0061] Columns: Agilent TC-C18 4.6mm × 250 mm 5 μm.

[0062] Mobile phase: methanol (batch number: 166578, level: HPLC, Source: Saimi Shil Technology Co., Ltd.) -0.1% phosphoric acid (batch number: T4901, ...

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Abstract

The invention relates to the field of traditional Chinese medicine preparation, in particular to granules for treating fatty liver and alcoholic liver injury and a preparation method. The granules areprepared from the following raw material medicines by weight: 150g of scorched hawthorn fruit, 100g of oriental wormwood, 100g of rhizoma alismatis, 75g of plantain herb, 75g of polygonum cuspidatum,100g of radix salviae miltiorrhizae, 45g of cooked rhubarb, 75g of cassia seeds, 100g of astragalus membranaceus, 75g of radix bupleuri, 75g of radix polygonum multiflorum preparata and 1000g of conventional auxiliary materials. By improving the formula and technological parameters, the tanshinone content is increased by more than three times; product stability is obviously improved; and the granules have good treatment and protection effects on fatty liver after hepatitis and fatty liver lesion caused by long-term alcoholism.

Description

Technical field [0001] The present invention relates to the field of traditional Chinese medicine pharmaceutical, namely, particles and preparation methods for the treatment of fatty liver and alcoholic liver injury. Background technique [0002] Original Qinggan Spleen Particle: Prescription: Hawthorn 150g, Yinchen (Coveling) 100g, Alisma 100g, car front grass 75g, Tiger Cum 75g, Danshen 100g, Rhubarb 45g, Cassia 75g, Astragalus 100g, Bupleurum 75g, Polygonum 75g, adding aid to 1000g. The disadvantage is: 1. Most of the hawthorn medicinal materials contain fruit cores, and the nucleus is invalid, accounting for large, the quantity is not fixed, causing the quantity of the feed and the difference in batch and batch. 2, prescriptions in the tiger sticks, rhubarb, decided to make a martial arts, and the diarrhea is strong. It is not conducive to the use of physical use, not conducive to long-term delivery. [0003] Original clearing controlled spleen particle preparation method: ab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61K9/16A61P1/16
CPCA61K36/734A61K36/282A61K36/884A61K36/68A61K36/704A61K36/537A61K36/708A61K36/482A61K36/481A61K36/233A61K9/1623A61P1/16A61K2236/333A61K2236/39A61K2236/331A61K2236/51A61K2300/00
Inventor 朱志杰杨宇敏江桐于晓琨刘跃东柳绪来李海陶渊喆刘永尹丹孙桂媛
Owner TONGHUA GOLDEN-HORSE PHARM IND CO LTD
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