Large-scale controllable fermentation method of medicated leaven with ten thousand-level cleanliness

A fermentation method and cleanliness technology, applied in the field of traditional Chinese medicine, can solve problems such as irregular production process, low fermentation efficiency, and cutting corners, and achieve the effects of standardized fermentation process, controllable fermentation conditions, and high fermentation efficiency

Pending Publication Date: 2021-04-06
HEBEI LIN YITANG MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The annual market demand for Liushenqu is relatively large, but there are few products with approval documents. Most of them are produced and processed by individual drug manufacturers, and the production process is extremely irregular and cut corners, resulting in significant differences in the quality of Liushenqu, which seriously affects the safety and efficacy of clinical medication.
Due to the limitation of natural conditions such as temperature and humidity, the fermentation conditions are extremely unstable, and the fermentation efficiency is low, so it cannot be continuously produced throughout the year
In addition, natural fermentation leads to excessive value-added of spoilage microorganisms, such as the value-added of Aspergillus flavus, which leads to excessive aflatoxin in Liushenqu, which seriously affects the safety of medication
However, the regional nature of the processing method leads to uneven quality of the finished products of Liushenqu, and it is difficult to make an objective evaluation of the quality of Liushenqu. At present, the quality of Liushenqu can only be simply evaluated from the perspectives of appearance, smell and microscope inspection, and there is a lack of quantification. Quality Evaluation Method

Method used

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  • Large-scale controllable fermentation method of medicated leaven with ten thousand-level cleanliness
  • Large-scale controllable fermentation method of medicated leaven with ten thousand-level cleanliness
  • Large-scale controllable fermentation method of medicated leaven with ten thousand-level cleanliness

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Step 1. Take the raw materials according to the following proportions: 0.25kg of Artemisia annua, 0.25kg of Polygonum, 0.25kg of Cocklebur, 3kg of Chixiaodou, 3kg of Bitter Almond, 25kg of wheat bran, and 50kg of flour, and pulverize through a 60-mesh sieve. Among them, Chixiaodou is crushed separately, added into cold water with 10 times the mass of Chixiaodou, stirred evenly, and then heated to boiling, stirring continuously during the heating process to prevent scorching, and boiled for 10 minutes to obtain viscous Chixiaodou water. Add the boiled Chixiaodou water to the raw material powder while it is hot, stir and mix thoroughly with a mixer, and adjust the water content in the raw material to 40wt.% by adding boiling water, and raise the temperature of the koji to 70±5°C. Put the pre-mixed koji material into a koji-making mold, press it into a 2±0.5cm square koji block, and place it in a fermentation tray. The height of the koji material is about 4-5cm high.

[00...

Embodiment 2

[0030] Step 1. Take the raw materials according to the following proportions: 1kg of Artemisia annua, 1kg of Polygonum lentils, 1kg of Cocklebur, 5kg of Chixiaodou, 5kg of bitter almonds, 30kg of wheat bran, 50kg of flour, and pulverize through a 60-mesh sieve. Among them, Chixiaodou is crushed separately, added into cold water with 10 times the mass of Chixiaodou, stirred evenly, and then heated to boiling, stirring continuously during the heating process to prevent scorching, and boiled for 10 minutes to obtain viscous Chixiaodou water. Add the boiled Chixiaodou water to the raw material powder while it is hot, stir and mix thoroughly with a mixer, and adjust the water content in the raw material to 40wt.% by adding boiling water, and raise the temperature of the koji to 70±5°C. Put the pre-mixed koji material into a koji-making mold, press it into a 2±0.5cm square koji block, and place it in a fermentation tray. The height of the koji material is about 4-5cm high.

[0031] ...

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Abstract

The invention discloses a large-scale controllable fermentation method of medicated leaven with ten thousand-level cleanliness. The method comprises the steps of crushing artemisia apiacea, red-knees herb, xanthium sibiricum herb, phaseolus calcaratus, semen armeniacae amarae, wheat bran and flour, adding water, stirring, and making starter; then putting the obtained starter material into a fermentation workshop with ten thousand-level cleanliness, and controlling the fermentation conditions as follows: the air cleanliness is the ten thousand level or above, the pressure of the fermentation workshop is kept to be 10Pa or above higher than the pressure of a non-clean area, the fermentation temperature is 25-35 DEG C, and the fermentation environment humidity is 70%-90%; and after the fermentation is finished, ventilating and drying to constant weight to obtain a medicated leaven finished product. According to the method, the medicated leaven starter material is fermented more fully, the content of effective fingerprint components in the product is higher than that in a traditional fermentation mode, the fermentation time is short, the fermentation efficiency is high, harmful infectious microbe pollution in the medicated leaven processing process is reduced, the medicated leaven fermentation process is standardized, unified and safe, and is not limited by natural conditions, and annual continuous production is achieved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a method for large-scale and controllable fermentation of Liushenqu with a cleanliness of ten thousand grades. Background technique [0002] Six Divine Comedy, also known as Liuqu and Divine Comedy, is a traditional Chinese medicinal composition made by natural fermentation after mixing Polygonum sativa, Artemisia annua, cocklebur, red bean, bitter almond, wheat bran and flour in a certain proportion. Liushenqu is sweet in taste and warm in nature. It belongs to the spleen and stomach meridian. It is the most widely used traditional koji. It has the effects of invigorating the spleen and harmonizing the stomach and promoting digestion. It is mainly used in the treatment of dietary stagnation , Chest swelling and abdominal distension, vomiting and diarrhea, postpartum blood stasis and abdominal pain, children with large abdominal firmness and othe...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/899A61K36/28A61K36/282A61K36/48A61K36/704A61K36/736A61P1/14A61P31/04
CPCA61K36/282A61K36/704A61K36/28A61K36/48A61K36/736A61K36/899A61P1/14A61P31/04A61K2236/19A61K2300/00
Inventor林飞武杨利博武玉翠田春雨
OwnerHEBEI LIN YITANG MEDICAL CO LTD