Wound flushing fluid as well as preparation method and application thereof

A technology for washing liquid and wounds, which is applied in the field of medicine, which can solve the problems of insufficient sterilization ability of normal saline, and achieve the effects of improving the ability of removing bacteria, reducing the incidence of wound infection, and improving permeability

Pending Publication Date: 2021-04-16
上海盈舜医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For this reason, the present invention provides a kind of wound flushing liquid, to solve t

Method used

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  • Wound flushing fluid as well as preparation method and application thereof
  • Wound flushing fluid as well as preparation method and application thereof
  • Wound flushing fluid as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0023]Example 1

[0024]In this embodiment, a wound rinse is provided which contains 1 g of the wound rinse liquid comprising 1 g of EDTA, 1G, 0.5 g of iodide, 2 g of sodium hydrogen sodium hydrogen phosphate, 2g of podium dihydrogen phosphate, and concentration High permeable saline for 100 mmol / L. The pH of the wound washing liquid was 7.4, while the wound washing liquid was sterilized. Among them, the sodium hydrogen sodium hydrogen phosphate and the pelvic dihydroduction solvent are better controlled by the pH of the flushing liquid, and the flushing liquid has better permeability. Adding EDTA's high permeable saline as a wound rinsing liquid, which can improve the ability to remove bacteria, reduce the incidence of wound infection; EDTA is widely used in clinical treatment, and it has good safety to the human body; EDTA is low, easy to promote At the same time, the addition of hydrogen peroxide further enhances the bactericidal efficiency of the flushing liquid, and the iodide c...

Example Embodiment

[0025]Example 2

[0026]This embodiment provides a method of preparing a wound rinsing liquid, comprising the steps of:

[0027]Step 1, 1.5-8 g of sodium hydrogen sodium hydrogen phosphate and 0.5-10 g of a dihydrodipotallic powder is blended in water, and an appropriate amount of activated carbon, stirred, stirred and adsorbed, and the mixed solution is obtained;

[0028]Step 2, the mixed solution of step 1 is added to high permeable saline in a concentration of 95-100 mmol / L, adjusting the pH and osmotic pressure to a suitable value; the pH is 7.4.

[0029]Step 3, 0.5-10 g of EDTA, 1-4 g of hydrogen oxide and 0.5-2 g of iodophytes were added to the mixed solution obtained in step 2, and sterilized treatment was performed to obtain the wound rinsing liquid.

Example Embodiment

[0030]Example 3

[0031]Efficacy and toxicity test

[0032]Materials and Method

[0033]The wound rinse solution refers to an EDTA concentration of 1 mmol / L (pH adjustment to 7.4) in EDTA concentration of 1 mmol / L in EDTA. Physiological saline and soap have been used as a control group. EDTA-NS solution and control group solution were treated with high pressure sterilization.

[0034]This study includes voxerical experiments and a variety of animal models to assess the efficacy of EDTA-NS. Introduction toxicity experiments were used to compare EDTA-NS using cellular activity test (membranous protein V / PI dyeing).

[0035]Physiological saline. Then we have established animal models of different wounds (accompany or non-bone exposed) with rats, and contaminated with goldenoglococcus or E. coli or infecting the wounds, in addition to the efficacy of EDTA-NS rinsing.

[0036]Cell activity analysis

[0037]Fibroblasts and endothelial cells are widely used in vitro experiments to detect toxicity of the ...

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Abstract

The invention belongs to the field of medicine, and discloses a wound flushing fluid. 1L of the wound flushing fluid comprises 0.5-10 g of EDTA, 1-4 g of hydrogen peroxide, 0.5-2 g of iodophor, 1.5-8 g of disodium hydrogen phosphate, 0.5-10 g of potassium dihydrogen phosphate and hypertonic saline water, wherein the concentration of the hypertonic saline water is 95-100 mmol/L, the PH value of the wound flushing fluid is 7.4, and the wound flushing fluid is sterilized. According to the invention, the high-permeability saline water added with EDTA (Ethylene Diamine Tetraacetic Acid) is used as the wound flushing fluid, so that the bacterium removal capability can be improved, and the wound infection occurrence rate is reduced; therefore, the problem of insufficient degerming capacity of normal saline in the prior art is solved; besides, the EDTA is widely applied to clinical treatment and has good safety to human bodies, is low in price and convenient to popularize and use.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a wound washing liquid and its preparation method and application. Background technique [0002] Treatment of open fractures requires thorough irrigation and debridement to prevent infection and promote healing. Adding surfactants, bactericides, etc. to the rinsing solution can improve the ability of the rinsing solution to remove bacteria. However, some studies have shown that, compared with normal saline, after adding the above substances, the ability to remove bacteria is improved, but the increase The biological toxicity of the washing solution. Therefore, recent studies recommend the use of saline without any added substances for irrigating, on the grounds that these substances increase the toxicity of the irrigating fluid and affect the therapeutic effect. Overall, in the treatment of open fractures, normal saline is still the preferred irrigation solution for most surge...

Claims

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Application Information

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IPC IPC(8): A61K33/40A61K9/08A61K47/02A61P17/02A61P31/02A61P31/04A61K31/198A61K31/79A61K33/14
Inventor 郑宪友朱弘一孙建
Owner 上海盈舜医疗科技有限公司
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