Research on determination method of whitening functional components in cosmetics

A technology of functional components and measurement methods, applied in the detection field of cosmetic components

Inactive Publication Date: 2021-04-20
上海微谱检测认证有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many methods for the determination of whitening functional ingredients in cosmetics, but there are few detection methods that simultaneously detect more than 10 whitening functional ingredients

Method used

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  • Research on determination method of whitening functional components in cosmetics
  • Research on determination method of whitening functional components in cosmetics
  • Research on determination method of whitening functional components in cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] The embodiment of the present invention specifically provides a research on the determination method of whitening functional ingredients in cosmetics. The steps include:

[0116] 1. Reference material and sample information

[0117] The information of 14 whitening functional ingredient standard products is shown in Table 7:

[0118] Table 7

[0119]

[0120]

[0121] 2. Solution preparation

[0122] 2.1 Processing of samples

[0123] 2.1.1 Treatment of water agent samples

[0124] Weigh 0.5g (accurate to 0.0001g) of aqueous solution sample into a 100mL beaker, add 30mL of solvent, stir with a glass rod for 1min, rinse the glass rod with solvent three times, 10mL each time, transfer all the rinse solution to the beaker; Drain the solution with a glass rod and transfer it to a 100mL volumetric flask, rinse the beaker with solvent three times, 10mL each time, transfer all the rinse solution to the volumetric flask, and obtain the processed sample;

[0125] Descr...

Embodiment 2

[0149] Embodiment 2 of the present invention specifically provides a kind of determination method research of whitening functional components in cosmetics, and the steps include:

[0150] 1. Reference material and sample information

[0151] The information of 14 kinds of standard products of whitening functional ingredients is the same as that in Example 1;

[0152] 2. Solution preparation

[0153] 2.1.2 Treatment of cream samples

[0154] Weigh 0.5g (accurate to 0.0001g) sample into a 5mL high-speed centrifuge tube, add 3mL isopropanol and 1wt% hydrochloric acid aqueous solution, shake well, vortex for 1min, centrifuge at 12000r / min for 10min, and remove the supernatant Transfer the solution to a 100mL volumetric flask, gently rinse the centrifuge tube three times with 3mL solvent, transfer all the rinse solution to the volumetric flask, then dilute to the mark with solvent, shake well, and let stand to obtain the processed sample;

[0155] Described solvent is with embod...

Embodiment 3

[0166] Example 3 of the present invention specifically provides a research on the determination method of whitening functional ingredients in cosmetics. The specific implementation method is the same as Example 2, except that the chromatographic column in the working condition of high performance liquid chromatography is ACQUITYUPLC HSS T3, 1.8μm, 2.1×100mm Column.

[0167] The final analysis results are as follows: the qualitative and quantitative analysis of the whitening functional ingredients in cosmetics can be carried out very well, the peaks of the target products can be well distinguished, with good selectivity, and the peak shape is symmetrical, the target peak There is no interference from impurity peaks around.

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Abstract

The invention relates to a detection method of cosmetic components, and in particular relates to research on a determination method of whitening functional components in cosmetics. The invention relates to research on the determination method of whitening functional components in cosmetics. The whitening functional components comprise nicotinamide, arbutin, tranexamic acid, potassium methoxysalicylate, dipotassium glycyrrhizinate, sophocarpidine, VC ethyl ether, allantoin, lactic acid, kojic acid, azelaic acid, salicylic acid, caffeic acid and sodium L-pyrrolidone-5-carboxylate. The method comprises the steps of (1) preparing a to-be-detected sample solution; (2) preparing a mixed standard solution; (3) carrying out high performance liquid chromatography-mass spectrometry analysis; (4) establishing a standard curve for analysis; and (5) simultaneously carrying out a blank experiment. The method for determining the 14 whitening functional components in the cosmetics has the characteristics of simplicity, convenience, quickness and sensitivity.

Description

technical field [0001] The invention relates to a detection method of cosmetic ingredients, in particular to the research on the measurement method of whitening functional ingredients in cosmetics. Background technique [0002] Having fair skin has always been the pursuit of most women. With the emergence of whitening cosmetics, more and more people use whitening cosmetics to reduce the deposition of spots and pigments. Therefore, the growth rate of whitening cosmetics is extremely fast. Through The detection of national risk monitoring samples of cosmetics found that there are fewer and fewer banned whitening ingredients, while the types and quantities of whitening functional ingredients are increasing. Chemical instruments are used to analyze the types and contents of whitening functional ingredients in whitening cosmetics , It is very important to infer whether the whitening effect and type and content will cause allergic reactions. At present, there are many determinati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/72G01N30/54
Inventor 裴丽娟冯俊孙鹏
Owner 上海微谱检测认证有限公司
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