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Arabic araboxylan and compound for preventing/treating gastrointestinal mucosa and liver injury

A technology for arabinoxylan and gastrointestinal mucosa, which is applied in the field of arabinoxylan and complexes for preventing/treating gastrointestinal mucosa and liver damage, and can solve the problems of low yield and difficult application of enzymatic methods.

Pending Publication Date: 2021-04-23
上海赛普瑞特生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the use of arabinoxylan for the prevention / treatment of alcohol-induced gastrointestinal mucosal and liver damage
[0006] Water extraction, chemical extraction, enzyme extraction and mechanical assisted extraction have been widely used in AX production. According to the extraction yield of AX, the alkali solvent method and mechanical assisted method have higher extraction efficiency, but due to the cost, equipment safety and Environmental and other issues are difficult to apply in industrial production; the yield of enzymatic method is low, but it can be combined with mechanical assisted method and chemical solvent method to improve AX yield; mechanical assisted method has the effect of improving AX yield, of which steam explosion method and Extrusion method has the advantages of environmental friendliness and is suitable for industrial production
Existing research on AX also focuses on yield, purity and other process conditions as well as intestinal microecology, physiological metabolism, immune function intervention, etc., and AX or its compound is used to prevent / treat alcoholic gastrointestinal mucosa and liver disease. The study of damage protection function has not been reported

Method used

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  • Arabic araboxylan and compound for preventing/treating gastrointestinal mucosa and liver injury
  • Arabic araboxylan and compound for preventing/treating gastrointestinal mucosa and liver injury
  • Arabic araboxylan and compound for preventing/treating gastrointestinal mucosa and liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The specific preparation method of arabinoxylan is as follows:

[0035] (1) Select 10kg of dry and mildew-free grain bran, add 100kg of NaOH solution with a mass concentration of 0.2%, heat it at 40°C for 2 hours, replace and wash with clean water, and then filter and dehydrate to obtain clean fiber.

[0036] (2) Add 80kg of NaOH solution with a mass concentration of 8% to the clean fiber obtained above, heat and extract at 60°C for 6 hours, and use a horizontal spiral sedimentation centrifuge to settle and centrifuge the extract to collect the first-level supernatant. 100 kg of NaOH solution with a mass concentration of 4% was used for continuous countercurrent replacement, and the replacement liquid was centrifuged with a butterfly centrifuge to collect the secondary supernatant, and the primary and secondary supernatants were combined to obtain 165 kg of arabinoxylan alkali solution.

[0037] (3) After the alkali solution of arabinoxylan is dealkalized by the ultrafi...

Embodiment 2

[0039] The specific preparation method of arabinoxylan is as follows:

[0040] (1) Select 1 kg of dry and mildew-free crushed corn cobs, add 10 kg of NaOH solution with a mass concentration of 1.0%, heat it at 90°C for 2 hours, replace and wash with clean water, and then filter and dehydrate to obtain clean fibers.

[0041] (2) Add 8 kg of NaOH solution with a mass concentration of 10% to the above-obtained clean fiber, heat and extract at 60°C for 6 hours, and use a horizontal spiral sedimentation centrifuge to settle and centrifuge the extract to collect the first-level supernatant, and then recycle the residue 10 kg of NaOH solution with a mass concentration of 4% was used for continuous countercurrent replacement, and the replacement liquid was centrifuged with a butterfly centrifuge to collect the secondary supernatant, and the primary and secondary supernatants were combined to obtain 16 kg of arabinoxylan alkali solution.

[0042] (3) After the arabinoxylan alkali solut...

Embodiment 3

[0044] The arabinoxylan complex for preventing / treating gastrointestinal mucosal and liver damage ① is obtained by mixing 80 parts by weight of arabinoxylan in Example 1 and 20 parts by weight of commercially available konjac powder with a glucomannan content of 85%.

[0045] The arabinoxylan complex ② for preventing / treating gastrointestinal mucosal and liver damage is obtained by mixing 95 parts by weight of arabinoxylan in Example 1 and 5 parts by weight of commercially available konjac powder with a glucomannan content of 85%.

[0046] The arabinoxylan compound ③ for preventing / treating gastrointestinal mucosal and liver damage is obtained by mixing 80 parts by weight of arabinoxylan in Example 2 and 20 parts by weight of commercially available konjac powder with a glucomannan content of 85%.

[0047] The arabinoxylan compound for preventing / treating gastrointestinal mucosa and liver damage ④ is obtained by mixing 95 parts by weight of arabinoxylan in Example 2 and 5 parts ...

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PUM

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Abstract

The invention discloses an application of araboxylan or a compound of the araboxylan and konjaku flour to preparation of foods, health care products or medicines for preventing / treating alcoholic gastrointestinal mucosa and liver injury. The araboxylan is prepared by pretreating plant raw materials to remove impurities and then performing alkali liquor extraction, dealkalization and purification. In the compound of the araboxylan and the konjaku flour, the mass ratio of the araboxylan accounts for 1-99%. The foods, the health care products or the medicines for preventing / treating the alcoholic gastrointestinal mucosa and liver injury are prepared from the araboxylan alone or the compound of the araboxylan and the konjaku flour, so that the injury of alcohol to the gastrointestinal mucosa and the liver can be effectively reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine and food, in particular to arabinoxylan and its compound for preventing / treating gastrointestinal mucosal and liver damage. Background technique [0002] Alcohol drinking is a traditional group preference, and it gradually has the attribute of social interaction, but excessive drinking can not only cause liver damage, but also damage the blood, digestion, cardiovascular and central nervous systems to varying degrees. Alcohol is an organic solvent that easily permeates biofilms and can be absorbed through the mucous membranes of the respiratory tract and digestive tract, and a small part is absorbed by the skin and other mucous membranes. The speed and degree of absorption depend on the concentration gradient of alcohol at the absorption site and the permeability of the membrane. sex and local blood flow. [0003] The liver is the main organ for alcohol metabolism. More than 90% of the alcohol in...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K36/888A61P1/04A61P1/16A23L33/125A23L33/21C08B37/14
CPCA61K31/715A61K36/888A61P1/04A61P1/16A23L33/125A23L33/21C08B37/0057A23V2002/00A61K2300/00A23V2200/32A23V2200/3202A23V2200/334A23V2250/5066A23V2250/5116
Inventor 李赐玉卢艺芳张永昌张永宁代兴华张厚瑞
Owner 上海赛普瑞特生物科技有限公司
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