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Bionic endometrium and preparation method thereof

A bionic uterus and endometrium technology, applied in the field of bionic endometrium and its preparation, can solve the problems of inability to improve adhesion recurrence rate, re-pregnancy rate and spontaneous abortion rate, etc.

Pending Publication Date: 2021-04-30
肖雁冰
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  • Application Information

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Problems solved by technology

[0003] The uterine cavity transplantation of human amniotic membrane and its products has been widely used in the clinical treatment of IUA, but the latest meta-analysis shows that the simple use of human amniotic membrane and its products after hysteroscopic adhesiolysis can only increase the menstrual flow of patients. Blood volume cannot improve the recurrence rate of adhesions, re-pregnancy rate and spontaneous abortion rate. The main reason for the above phenomenon is related to the unique structure of human fresh amniotic membrane. Cells are not easy to adhere and fuse with it, so the present invention proposes a bionic endometrium and its preparation method to solve the problems existing in the prior art

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  • Bionic endometrium and preparation method thereof

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Embodiment Construction

[0024] In order to deepen the understanding of the present invention, the present invention will be further described below in conjunction with the examples, which are only used to explain the present invention, and do not constitute a limitation to the protection scope of the present invention.

[0025] according to figure 1 As shown, the present embodiment proposes a bionic endometrium, including two groups of mirror-symmetrical BAM (bionic amnion), and ESC (endometrial stromal cells) are arranged between the two groups of BAM (bionic amnion) .

[0026] A preparation method of bionic endometrium, characterized in that: comprising the following steps:

[0027] Step 1: Preparation of hAAM (human decellularized amniotic membrane)

[0028] Human fresh amniotic tissue was obtained from cesarean section of normal pregnant women, rinsed thoroughly with saline to remove blood and other impurities that may adhere to the surface, and then cross-linked with glutaraldehyde overnight, ...

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Abstract

The invention discloses a bionic endometrium and a preparation method thereof. The bionic endometrium comprises two groups of BAMs (bionic amnions) in mirror symmetry, an ESC (endometrial stromal cells) is arranged between the two groups of BAMs, and according to the bionic endometrium and the preparation method thereof, the ESC is arranged between the two groups of BAMs in mirror symmetry. The BAM is formed in a sandwich structure mode, the hAAM on the two outer layers is provided with a double-layer basement membrane, rich natural fiber tissues are contained in the basement membrane, so that the mechanical strength of the membrane is improved, and the performance of converting the membrane into the endometrium is improved. Sufficient biomechanical strength close to the mechanical property of a fresh amnion can be formed through reinforcement from the front and rear aspects, and in addition, under the fixing action of clamping of the double-layer hAAM and field planting fusion of the hAMSCs, better tensile strength, elasticity and extension property are achieved.

Description

technical field [0001] The invention relates to the technical field of bioengineering, in particular to a bionic endometrium and a preparation method thereof. Background technique [0002] Intrauterine Adhesions (IUA) refers to the endometrial basal layer damage and scar healing due to injury or infection, resulting in partial or complete adhesion of the uterine cavity, uterine isthmus and cervical canal wall, causing Clinical disease with symptoms such as uterine cavity shrinkage, effective endometrial immunity reduction, menstrual flow reduction and even amenorrhea. With the increase of painless abortion and uterine curettage, the incidence of IUA is increasing year by year, and the degree of adhesion is gradually aggravating, seriously affecting women's physical and mental health and fertility; [0003] The uterine cavity transplantation of human amniotic membrane and its products has been widely used in the clinical treatment of IUA, but the latest meta-analysis shows t...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/38A61L27/50
CPCA61L27/3604A61L27/3679A61L27/3687A61L27/3691A61L27/3834A61L27/3882A61L27/50A61L2430/22
Inventor 肖雁冰蒋成素杨定英
Owner 肖雁冰
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