Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

1, 2-hexanediol as well as purification method and application thereof

A purification method and technology for hexanediol, applied in the field of 1,2-hexanediol and its purification, can solve the problems of low yield, large loss and the like

Pending Publication Date: 2021-05-11
SHANGHAI VASTPRO TECH DEV CO LTD
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This production method has a large loss and low yield, which leads to the price of 1,2-hexanediol directly used in the cosmetics industry is more than 3 times higher than that of 1,2-hexanediol containing odor

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • 1, 2-hexanediol as well as purification method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Step 1: Preparation of 1,2-hexanediol crude product

[0027] In a 500mL three-necked flask, equipped with a thermometer, dropping funnel, and a low-temperature reflux condenser. 140.0 g of 88% formic acid and 75.0 g of 1-hexene were sequentially added at room temperature. The temperature was raised to 50° C. with stirring, and 110.0 g of 30% hydrogen peroxide was slowly added dropwise. Stir at 55°C until the reaction is complete. 275.0 g of 40% NaOH aqueous solution was added dropwise, and the mixture was stirred at 20-25° C. for 1 hour after the drop was completed. The reaction system was left to stand for stratification, and the upper layer was taken and rectified under vacuum to obtain 47.6 g of product main fraction, GC purity 99.56%, moisture 0.23%, and main fraction yield 45.33%.

[0028] Step 2: Purify crude 1,2-hexanediol by adding sodium borohydride

[0029] In a 500mL three-necked flask, add 320g of the product obtained in step (1), slowly add 0.64g of sod...

Embodiment 2

[0030] Example 2 Purification of 1,2-hexanediol crude product by adding potassium borohydride

[0031] Step 1: Preparation of 1,2-hexanediol crude product

[0032] In a 500mL three-necked flask, equipped with a thermometer, dropping funnel, and a low-temperature reflux condenser. 140.0 g of 88% formic acid and 75.0 g of 1-hexene were sequentially added at room temperature. The temperature was raised to 50° C. with stirring, and 110.0 g of 30% hydrogen peroxide was slowly added dropwise. Stir at 55°C until the reaction is complete. 275.0 g of 40% NaOH aqueous solution was added dropwise, and the mixture was stirred at 20-25° C. for 1 hour after the drop was completed. The reaction system was left to stand for stratification, and the upper layer was taken and rectified under vacuum to obtain 47.6 g of product main fraction, GC purity 99.56%, moisture 0.23%, and main fraction yield 45.33%.

[0033] Step 2: Purify the crude product of 1,2-hexanediol by adding potassium borohyd...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
purityaaaaaaaaaa
Login to View More

Abstract

The invention discloses 1, 2-hexanediol as well as a purification method and application thereof. The invention provides a purification method of 1, 2-hexanediol, and the purification method comprises the following steps: (1) treating a 1, 2-hexanediol crude product by using metal borohydride; and according to the method for purifying the 1, 2-hexanediol, provided by the invention, odor impurities in the 1, 2-hexanediol product can be removed, so that the 1, 2-hexanediol product is extremely low in traditional Chinese medicine odor or has no traditional Chinese medicine odor, and the method is more suitable for being used in high-grade cosmetics. The method for purifying 1, 2-hexanediol provided by the invention is simple in process, low in cost and easy to industrialize.

Description

technical field [0001] The embodiments of the present invention relate to the field of cosmetic manufacturing, in particular to 1,2-hexanediol and a purification method and use thereof. Background technique [0002] 1,2-Hexanediol is an important chemical raw material, which is mostly used in inks for color inkjet printers, advanced cosmetics and synthetic raw materials in the pharmaceutical industry. 1,2-Hexanediol is a colorless and transparent viscous liquid that can be mixed with various organic compounds in any proportion and is easily soluble in water. Among them, in the field of cosmetics, 1,2-hexanediol is a good additive because it is non-irritating to the human body and has good moisturizing and antibacterial effects. The traditional method of synthesizing 1,2-hexanediol generally uses 1-hexene as the starting material, and generates 1,2-hexanediol through two processes of epoxidation and hydrolysis of an oxidant. The unpleasant smell similar to traditional Chine...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C29/88C07C31/20A61K8/34
CPCC07C29/88A61K8/345C07C31/20
Inventor 何成涛郭朋朱文峰
Owner SHANGHAI VASTPRO TECH DEV CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com