DC cell culture method, culture medium, DC treatment strategy-based drug and application of tyrosine kinase inhibitor in preparation of DC cell culture medium

A tyrosine kinase and cell culture technology, which is applied in the field of preparation of tyrosine kinase inhibitors, can solve the problems that DC cell culture methods cannot meet, and achieve high maturity or high activity, increase maturity or Activity, effect of improving expression
CN112852732APending Publication Date: 2021-05-28SICHUAN PROVINCIAL PEOPLES HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SICHUAN PROVINCIAL PEOPLES HOSPITAL
Publication Date
2021-05-28

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Abstract

The invention discloses a DC cell culture method, a culture medium, a DC treatment strategy-based drug and application of a tyrosine kinase inhibitor in preparation of the DC cell culture medium. According to the DC cell culture method, in the culture process of induced differentiation of immature DC cells, a tyrosine kinase inhibitor is added into a culture medium, and the mature DC cells are obtained through induced differentiation culture; the culture medium is a cell culture medium containing a tyrosine kinase inhibitor and can be used for culturing immature DC cells which are induced to be differentiated into mature DC cells; the medicine based on the DC treatment strategy contains a tyrosine kinase inhibitor; and the tyrosine kinase inhibitor can be used in the preparation of the DC treatment strategy-based medicine. According to the scheme, the problem that an existing DC cell culture method cannot meet the requirement for highly mature or high-activity DC cells required by clinical curative effects can be solved, and the aim of improving the maturity or activity of the DC cells is achieved.
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Description

technical field

[0001] The invention relates to the related technical field of DC cells, in particular to a method for culturing DC cells, a culture medium, a drug based on a DC treatment strategy, and an application of a tyrosine kinase inhibitor in the preparation thereof. Background technique

[0002] DC cells (dendritic cells), as the most important antigen-presenting cells, can play an important role in anti-tumor immunity by priming naive T cells and promoting their proliferation and differentiation into Th cells and cytotoxic T lymphocytes (CTL) .

[0003] In the past few decades, anti-tumor treatment strategies based on DC cells have developed rapidly; for example, cultivating autologous dendritic cells to enhance their activity, and then reinfusing them into patients is the cutting-edge technology of current research and application. Not only can it effectively stimulate the anti-tumor immune response in tumor patients, and it has shown good curative effect in rese...

Claims

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