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Application of paliurus ramosissimus or paliurus ramosissimus extract in preparation of pulp capping material

A technology of extracts and vesicles, applied in the field of medicine, can solve the problems of poor anti-inflammatory properties and the inability to directly cap the pulp with mild inflammation, achieve obvious effects, solve poor anti-inflammatory properties, and improve the ability of dental pulp repair Effect

Pending Publication Date: 2021-06-04
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a new application of safflower seed or its extract as a pulp capping material, which can effectively solve the technical problem that the existing pulp capping materials have poor anti-inflammatory properties and cannot be used for direct pulp capping of mildly inflammatory pulp

Method used

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  • Application of paliurus ramosissimus or paliurus ramosissimus extract in preparation of pulp capping material
  • Application of paliurus ramosissimus or paliurus ramosissimus extract in preparation of pulp capping material
  • Application of paliurus ramosissimus or paliurus ramosissimus extract in preparation of pulp capping material

Examples

Experimental program
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Effect test

Embodiment 1

[0019] The technical scheme of present embodiment 1 is as follows:

[0020] 1. Preparation of Majiazi pulp capping material

[0021] The process of preparing the solution of the vegetal seed extract is as follows:

[0022] Step (1): Weigh the extract, dimethyl sulfoxide, and cell culture solution according to the ratio of 250 μg: 10 μl: 1 ml, respectively;

[0023] Step (2): In a centrifuge tube, mix the extract of the safflower seed with the dimethyl sulfoxide solution, and vibrate with an oscillator for 6 minutes, so that the safflower seed extract is dissolved in the dimethyl sulfoxide solution;

[0024] Step (3): Add the cell culture solution taken out in step (1) to the dimethyl sulfoxide solution obtained in step (2), and vibrate with an oscillator for 20 minutes to dissolve the components in the tube to obtain a mixed solution;

[0025] Step (4): Use a bacterial filter (0.22 μm) to filter the mixed solution obtained in step (3) under a sterile ultra-clean bench, to ob...

Embodiment 2

[0042] The difference between the present embodiment 2 and the embodiment 1 is only that the pulp capping material in the embodiment 1 is replaced with the fresh product of the safflower by the crushed product of the saccharomyces chinensis; wherein, the preparation method of the crushed product of the saccharomyces sacrum fresh product is as follows : take 1kg of the fresh product of the whole plant of the plant of Saccharomyces japonicus as a raw material drug, pulverize through a pulverizer, and pass through a 60-mesh medicine sieve to obtain the crushed product of the fresh product of Saccharomyces japonicus.

[0043] The experimental results obtained in Example 2 are consistent with those in Example 1, indicating that the crushed fresh product of Majiazi can ensure the growth and proliferation of cells in vitro, and at the same time inhibit the cell inflammation induced by LPS.

Embodiment 3

[0045] The difference between this Example 3 and Example 1 is only that the pulp capping material in Example 1 is replaced with the dried and crushed product of Saccharomyces chinensis by the saccharomyces sacrum extract; wherein, the preparation method of the saccharomyces sacrum dry product and crushed product is as follows : take 2kg of the fresh product of the whole plant of Scutellaria japonicus as a raw material drug, dry, pulverize through a pulverizer, and pass through an 80-mesh drug sieve to obtain the dry product and crushed product of Saccharomyces japonicus.

[0046] The experimental results obtained in Example 3 are consistent with those in Example 1, indicating that the dried and pulverized product of S. japonicus can ensure the growth and proliferation of cells in vitro, and at the same time inhibit the cell inflammation induced by LPS.

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Abstract

The invention discloses application of paliurus ramosissimus or paliurus ramosissimus extract in preparation of a pulp capping material, and belongs to the field of medicine. According to the invention, a fresh paliurus ramosissimus product, a dry crushed paliurus ramosissimus product or the paliurus ramosissimus extract is taken as an active ingredient to serve as the pulp capping material, and the pulp capping material has stable and lasting anti-inflammatory performance, can promote hard tissue formation and improve dental pulp repair capacity, has an obvious effect and is better than clinical common control drugs, and therefore, technical problems that an existing pulp capping material is poor in anti-inflammatory performance and cannot be used for directly capping the pulp of the slightly-inflammatory dental pulp can be effectively solved.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to the use of the vetch seed or its extract in the preparation of pulp capping materials. Background technique [0002] Paliurus ramosissimus (Lour.) Poir is a deciduous shrub belonging to Rhamnaceae, also known as iron fence and copper money tree, and is a common medicinal plant. It is reported that the branches, leaves, roots, flowers and fruits are all medicinal, with bitter nature and flavor, flat, non-toxic, can remove cold and activate blood circulation, relieve fever, reduce swelling, and treat bruises and subordinate pain. However, there has not been any report that Saccharomyces japonicus or its extracts can be used for pulp capping treatment of mildly inflammatory pulp. [0003] Carious pulp penetration, mechanical pulp penetration and traumatic pulp penetration will all lead to the exposure of viable pulp. Direct pulp capping is to directly cover the exposed pulp wound wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/72A61P1/00A61P29/00
CPCA61K36/72A61P1/00A61P29/00
Inventor 苏勤李向芬郭方亮邢桂琪郭林溪徐超群
Owner SICHUAN UNIV
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