The invention discloses a medicine for treating blood coagulation and toxin accumulating bedsore and a preparation method of the medicine. The medicine comprises the following active ingredients: radix pseudostellariae, codonopsis pilosula, Chinese yam, tangerine peel, pericarpium citri reticulatae viride, blumea, spina gleditsiae, radix tinosporae, a manystem stonecrop leaf, pachysandra stylosa dunn, resina liquidamberis, salvia miltiorrhiza, paliurus ramosissimus, oxhide gelatin, rubia yunnanensis, a cowherb seed, a pangolin, amomum tsao-ko, radix angelicae, a nandina root, a loose knot, lithospermum, all-grass of Ames Vanda, vernonia gratiosa, rhizoma anemarrhenae, pollen, Chinese angelica, an Indian melothria root and liquorice. The medicine has the benefits that the medicine has effects of tonifying qi, promoting blood circulation, draining toxin and expelling decay, and has a good curative effect on the blood coagulation and toxin accumulating bedsore, a preparation technology is simple and convenient, the medicine has low toxic and side effects, is convenient to administer, can reach a focus and has shorter treatment course and low recurrence possibility after curing, and an agent is easy to manufacture and low in cost.