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Paliurus ramosissimus total triterpene dry paste and technology thereof

A technology of triterpene dry paste and total triterpenes, which is applied to plant raw materials, plant/algae/fungus/moss components, medical preparations containing active ingredients, etc., can solve the problems of not being able to meet the five types of new drug raw materials, and achieve Slight harmful residue of solvent, convenient column chromatography, suitable column efficiency effect

Inactive Publication Date: 2020-06-02
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing preparation method of total triterpenoids of sarcocarpus can only make the content of active ingredients betulinic acid and sacrinin in the total triterpenes reach only about 40%, which makes it unable to meet the standard of becoming a five-category new drug raw material drug

Method used

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  • Paliurus ramosissimus total triterpene dry paste and technology thereof
  • Paliurus ramosissimus total triterpene dry paste and technology thereof
  • Paliurus ramosissimus total triterpene dry paste and technology thereof

Examples

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Embodiment 1

[0030] A kind of preparation technology of total triterpene dry paste of Majiazi:

[0031] (1) The cotyledon is extracted by percolation with 95% ethanol (solid-liquid ratio 1:10), and the percolation extract is decompressed to recover ethanol, and dried under reduced pressure (vacuum degree of decompression drying <0.09mpa, drying temperature at 50°C, dried 24-48h), to obtain alcohol extract extract powder;

[0032] (2) Add an extraction solvent (the ratio of solid to liquid is 1:30) to the alcohol extract extract powder, the extraction solvent is made by mixing 95% ethanol and ethyl acetate in a volume ratio of 1:4; magnetically stir for 1h, extract Suction filtration twice, combine the filtrates, and dry under reduced pressure (vacuum degree of vacuum drying <0.09mpa, drying temperature at 50°C, drying for 24-48h), to obtain the fine extract of Semen japonica;

[0033] (3) Adding ethanol with a volume fraction of 75% (the ratio of solid to liquid is 1:150) to the fine extr...

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Abstract

The present invention discloses a preparation technology of paliurus ramosissimus total triterpene dry paste. Paliurus ramosissimus leaves are subjected to percolation extraction by using 95% ethanolwith 10 times amount, a percolation extract is subjected to ethanol recovery under reduced pressure, and ethanol extract powder is obtained by vacuum drying; an appropriate amount of the ethanol extract powder is weighed, magnetic stirring with 95% ethanol-ethyl acetate is conducted for twice, filtrates are combined after suction filtration, and drying under reduced pressure is conducted to obtaina fine paliurus ramosissimus extract; then 75% ethanol is added for magnetic stirring, then suction filtration is conducted, a filtrate is loaded on a MCI-GEL resin column, and filling column-loadingamount is 10 times amount of the fine extract; after samples are loaded, 75% ethanol is used for continuous elution for 1 time column volume, and an eluent is discarded; 95% ethanol is changed for continuous elution with a MCI-GEL column, elution is conducted for 2 time column volume, an eluent is collected; ethanol is recovered under reduced pressure to be dry to obtain the paliurus ramosissimustotal triterpene dry paste, a sum of content of effective components of paliurus ramosissimus essence and betulinic acid is greater than 50%, and harmful residues of solvents are slight; and selectedfilling loaded chromatographic columns belong to atmospheric columns which are convenient for column chromatography and also have a more suitable column efficiency.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a process for extracting the fruit of the plant and a process for extracting the plant. Background technique [0002] Paliurus ramosissimus is a shrub plant of the genus Paliurus ramosissimus in the family Rhamnaceae. It is non-toxic and has a wide range of pharmacological activities. It is widely distributed and has many folk applications. "Zhonghua Materia Medica" records (all local drug annals have similar records), Ma Jiazi root can dispel wind and disperse blood stasis, detoxify and reduce swelling, has the effect of clearing away heat and detoxification, and is mainly used for furuncles and carbuncles, and unknown swollen toxins. Although ancient books have recorded the efficacy and use of vetch, domestic and foreign scholars have not done enough basic research on the chemical composition or activity of vetch. Research on chemical components: Scholars...

Claims

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Application Information

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IPC IPC(8): A61K36/72A61P35/00
CPCA61K36/72A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61P35/00
Inventor 谭镭詹雁徐超群阮佳
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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