Application of paliurus ramosissimus or extract thereof in preparing anti-tumor metastasis medicines

A technology of giard seed and extract, which is applied in the field of preparing anti-tumor metastasis drugs, can solve the problems of inability to inhibit tumor metastasis, and there is no good treatment method for tumor metastasis, and achieve the effects of inhibiting tumor cell migration and having good application prospects.

Inactive Publication Date: 2019-12-10
四川梓橦宫药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Studies have found that most anti-tumor drugs cannot inhibit tumor metastasis, and there is currently no good treatment for tumor metastasis

Method used

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  • Application of paliurus ramosissimus or extract thereof in preparing anti-tumor metastasis medicines
  • Application of paliurus ramosissimus or extract thereof in preparing anti-tumor metastasis medicines
  • Application of paliurus ramosissimus or extract thereof in preparing anti-tumor metastasis medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1, the preparation of the fresh product ethanol extract (EA) of Semen japonicus

[0029] Method (1) Take 1 kg of the fresh plant of the whole plant of Scutellaria chinensis (or any part thereof, such as roots, stems, leaves, etc.), add 10 times of 95% ethanol and soak it for 1-2 days, take out the sarcocarpus medicinal material, evaporate the ethanol to dryness, Pulverize, and then soak in the original solvent for 3 days, collect the extract, recover ethanol under reduced pressure, and dry the concentrated solution to obtain the ethanol extract of Echinacea, which is named EA-1.

[0030] Method (2) Take 1 kg of the fresh plant of the whole plant (or any part thereof, such as root, stem, leaf, etc.), crush it, add 10 times of 95% ethanol to reflux and extract for 3 times, collect the extract, and recover the ethanol under reduced pressure , and the concentrated solution is dried to obtain the ethanol extract of the seedlings, which is named EA-2.

[0031] Met...

Embodiment 2

[0032] Embodiment 2, the preparation of the fresh leaf ethyl acetate extract (EAEPR) of Semen japonicus

[0033] Method (1) Concentrated solution of the ethanol extract of the fresh leaves of C. japonicus, after extracting 3 times with 5 times of petroleum ether, retaining the water phase, extracting the water phase with 5 times of ethyl acetate for 3 times, drying after recovering the ethyl acetate under reduced pressure, That is the ethyl acetate extract, named EAEPR-1.

[0034] Method (2) Dried sample of the ethanol extract of Scutellaria chinensis, add 4 to 20 times of water to suspend, extract 3 times with 5 times of petroleum ether, keep the water phase, extract the water phase with 5 times of ethyl acetate for 3 times, and recover under reduced pressure After ethyl acetate was dried, the ethyl acetate extract was obtained, which was named EAEPR-2.

[0035] Method (3) Dry the sample of the ethanol extract of Scutellaria chinensis, extract with 5 times of ethyl acetate r...

Embodiment 3

[0036] Embodiment 3, the preparation of the dried leaf ethanol extract of Semen japonicus

[0037] Using the same method as method 1 in Example 1, the fresh plant of the whole plant of Saccharomyces japonicus was replaced by the dried leaves of Saccharomyces japonicus to obtain the ethanol extract of the dried leaves of Saccharomyces japonicus.

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PUM

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Abstract

The invention provides application of paliurus ramosissimus or an extract thereof in preparing anti-tumor metastasis medicines. Specifically, the paliurus ramosissimus extract is an ethanol extract orethyl acetate extract of fresh leaves of paliurus ramosissimus. Experiment shows that the paliurus ramosissimus extract has a remarkable inhibition function on tumor metastasis, and has very good application prospects in preparing anti-tumor metastasis medicines.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the use of the seeds of safflower or its extracts in the preparation of anti-tumor metastasis medicines. Background technique [0002] Tumor metastasis is the main way of tumor spread, which can make tumor cells spread to multiple systems or organs of the human body, and is an important cause of tumor aggravation or death. Tumors are divided into benign tumors and malignant tumors, and one of the most important characteristics of malignant tumor cells is metastasis, that is, metastasis from the primary tumor to other sites to form metastases and maintain the growth of recurrent tumors, which is the primary cause of death of cancer patients caused by tumor metastasis. factor. [0003] Only a small fraction of cells in the primary tumor have the ability to metastasize. Tumor metastasis is different from the mechanism of tumorigenesis. It is a multi-stage process of multi-factor and multi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/72A61P35/04A61P35/00A61K127/00
CPCA61K36/72A61K2236/333A61K2236/51A61K2236/53A61P35/00A61P35/04
Inventor 李东晓周静徐超群
Owner 四川梓橦宫药业股份有限公司
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